Cell-to-cell variability in troponin I phosphorylation in a porcine model of pacing-induced heart failure [0.03%]
家猪心律诱发的心力衰竭中肌钙蛋白I磷酸化的细胞间差异性研究
Dániel Czuriga,Attila Tóth,Eniko T Pásztor et al.
Dániel Czuriga et al.
We tested the hypothesis that myocardial contractile protein phosphorylation and the Ca(2+) sensitivity of force production are dysregulated in a porcine model of pacing-induced heart failure (HF). The level of protein kinase A (PKA)-depend...
Johan M Lorenzen,Filippo Martino,Thomas Thum
Johan M Lorenzen
Epigenetics represents a phenomenon of altered heritable phenotypic expression of genetic information occurring without changes in DNA sequence. Epigenetic modifications control embryonic development, differentiation and stem cell (re)progr...
Overfed Ossabaw swine with early stage metabolic syndrome have normal coronary collateral development in response to chronic ischemia [0.03%]
肥胖的奥萨巴猪在代谢综合征的早期阶段对慢性缺血的冠状动脉侧支发育正常响应
Antonio D Lassaletta,Louis M Chu,Michael P Robich et al.
Antonio D Lassaletta et al.
Ossabaw miniswine have been naturally selected to efficiently store large amounts of lipids offering them a survival advantage. Our goal was to evaluate the myocardial response to chronic ischemia of the Ossabaw consuming a hypercaloric, hi...
Remote cardioprotection by direct peripheral nerve stimulation and topical capsaicin is mediated by circulating humoral factors [0.03%]
远程心脏保护通过直接外周神经刺激和局部使用辣椒素介导循环中的体液因子实现
Kathrine L Redington,Tara Disenhouse,Samuel C Strantzas et al.
Kathrine L Redington et al.
We have previously shown that remote ischemic preconditioning by limb ischemia (rIPC) or intra-arterial adenosine releases a dialyzable cardioprotective circulating factor(s), the release of which requires an intact neural connection to the...
Sgk1 sensitivity of Na(+)/H(+) exchanger activity and cardiac remodeling following pressure overload [0.03%]
压力超负荷后Na+/H+交换子活性和心脏重构的Sgk1敏感性
Jakob Voelkl,Yun Lin,Ioana Alesutan et al.
Jakob Voelkl et al.
Sustained increase of cardiac workload is known to trigger cardiac remodeling with eventual development of cardiac failure. Compelling evidence points to a critical role of enhanced cardiac Na(+)/H(+) exchanger (NHE1) activity in the underl...
Cellular FLICE-inhibitory protein protects against cardiac remodelling after myocardial infarction [0.03%]
胞质FLICE抑制蛋白可保护心肌梗死后的心脏重构
Jinfeng Xiao,Mark Moon,Ling Yan et al.
Jinfeng Xiao et al.
Cellular FLICE-inhibitory protein (cFLIP) is a member of the tumour necrosis factor signalling pathway and a regulator of apoptosis, and it has a role in cardiac remodelling following myocardial infarction (MI) that remains largely uncharac...
Vascular endothelial dysfunction in Duchenne muscular dystrophy is restored by bradykinin through upregulation of eNOS and nNOS [0.03%]
血管内皮功能障碍可以通过增加eNOS和nNOS的表达来修复
Hubert Dabiré,Inès Barthélémy,Nicolas Blanchard-Gutton et al.
Hubert Dabiré et al.
Little is known about the vascular function and expression of endothelial and neuronal nitric oxide synthases (eNOS and nNOS) in Duchenne muscular dystrophy (DMD). Bradykinin is involved in the regulation of eNOS expression induced by angio...
Reverse chamber remodelling following adrenergic-induced advanced cardiac dilatation and pump dysfunction [0.03%]
肾上腺素诱导的心脏扩张和泵功能障碍后的心室逆向重构
Hendrik L Booysen,Gavin R Norton,Lionel H Opie et al.
Hendrik L Booysen et al.
As adrenergic-induced cardiac dilatation is associated with cardiomyocyte cell death, whether cessation of excessive adrenergic effects can achieve complete reverse chamber remodelling in established cardiac dilatation and pump dysfunction ...
The link between metabolic abnormalities and endothelial dysfunction in type 2 diabetes: an update [0.03%]
2型糖尿病代谢异常和内皮功能障碍关系的研究进展
Hanrui Zhang,Kevin C Dellsperger,Cuihua Zhang
Hanrui Zhang
Despite abundant clinical evidence linking metabolic abnormalities to diabetic vasculopathy, the molecular basis of individual susceptibility to diabetic vascular complications is still largely undetermined. Endothelial dysfunction in diabe...
Defective proteolytic systems in Mybpc3-targeted mice with cardiac hypertrophy [0.03%]
Mybpc3靶点小鼠心室肥厚表型中的缺陷蛋白酶系统
Saskia Schlossarek,Daniel R Englmann,Karim R Sultan et al.
Saskia Schlossarek et al.
Several lines of evidence suggest that alterations of the ubiquitin-proteasome system (UPS) and autophagy-lysosome pathway (ALP) may be involved in cardiac diseases. Little is known, however, in hypertrophic cardiomyopathy (HCM). This study...