Stefan Rupp,Jürgen Bauer,Susanne von Gerlach et al.
Stefan Rupp et al.
Recent studies suggest that the mammalian heart possesses some capacity for cardiac regeneration. This regenerative capacity is primarily documented postnatally and after myocardial infarction or pressure overload. Although the cell type th...
Inhibition of Na/K-ATPase promotes myocardial tumor necrosis factor-alpha protein expression and cardiac dysfunction via calcium/mTOR signaling in endotoxemia [0.03%]
Na+/K+ -ATP酶抑制通过钙信号/m TOR促进内毒素血症心肌肿瘤坏死因子α蛋白表达和心脏功能障碍
Ting Zhang,Xiangru Lu,Jenny Li et al.
Ting Zhang et al.
Tumor necrosis factor-α (TNF-α) is a major pro-inflammatory cytokine that causes cardiac dysfunction during sepsis. Na/K-ATPase regulates intracellular Ca(2+), which activates mammalian target of rapamycin (mTOR), a regulator of protein s...
Identification of inducible nitric oxide synthase in peripheral blood cells as a mediator of myocardial ischemia/reperfusion injury [0.03%]
外周血细胞诱导型一氧化氮合酶作为心肌缺血/再灌注损伤介导因子的鉴定研究
Yiru Guo,Santosh K Sanganalmath,Wenjian Wu et al.
Yiru Guo et al.
Although the late phase of ischemic preconditioning is known to be mediated by increased inducible nitric oxide synthase (iNOS) activity, controversy persists regarding the role of iNOS in ischemia/reperfusion (I/R) injury and, specifically...
Proarrhythmia in a non-failing murine model of cardiac-specific Na+/Ca 2+ exchanger overexpression: whole heart and cellular mechanisms [0.03%]
心脏特异性Na+/Ca2+交换器过度表达小鼠模型中的促心律失常：整体心脏和细胞机制
Christian Pott,Adam Muszynski,Matthias Ruhe et al.
Christian Pott et al.
The cardiac Na(+)/Ca(2+) exchanger (NCX) generates an inward electrical current during SR-Ca(2+) release, thus possibly promoting afterdepolarizations of the action potential (AP). We used transgenic mice 12.5 weeks or younger with cardiomy...
S100A8/A9 aggravates post-ischemic heart failure through activation of RAGE-dependent NF-κB signaling [0.03%]
S100A8/A9通过激活RAGE依赖的NF-κB信号加重缺血性心力衰竭
H Christian Volz,Danai Laohachewin,Cathrin Seidel et al.
H Christian Volz et al.
The extracellular heterodimeric protein S100A8/A9 activates the innate immune system through activation of the receptor of advanced glycation end products (RAGE) and Toll-like receptors. As activation of RAGE has recently been associated wi...
Diastolic tolerance to systolic pressures closely reflects systolic performance in patients with coronary heart disease [0.03%]
冠心病患者的舒张压对收缩压的耐受性可反映其收缩功能状况
Adelino F Leite-Moreira,André P Lourenço,Roberto Roncon-Albuquerque Jr et al.
Adelino F Leite-Moreira et al.
In animal experiments, elevating systolic pressures induces diastolic dysfunction and may contribute to congestion, a finding not yet translated to humans. Coronary surgery patients (63 ± 8 years) were studied with left ventricular (LV) pr...
Chronic treatment with long acting phosphodiesterase-5 inhibitor tadalafil alters proteomic changes associated with cytoskeletal rearrangement and redox regulation in Type 2 diabetic hearts [0.03%]
长期使用磷酸二酯酶-5延长释放型抑制剂他达拉非治疗可改变2型糖尿病心脏中与细胞骨架重塑和氧化还原调节相关的蛋白质组变化
Saisudha Koka,Lei Xi,Rakesh C Kukreja
Saisudha Koka
Diabetic patients are prone to metabolic perturbations that progressively contribute to structural, functional and proteomic alterations in the myocardium. Phosphodiesterase-5 (PDE-5) inhibitors exhibit cardioprotective effects against isch...
Cardiac FKBP12.6 overexpression protects against triggered ventricular tachycardia in pressure overloaded mouse hearts [0.03%]
心内压过载小鼠心脏触发性室速的FKBP12.6过表达保护作用研究
Laurent Vinet,Mylène Pezet,Virginie Bito et al.
Laurent Vinet et al.
Alterations in RyR2 function have been proposed as a major pathophysiological mechanism of arrhythmias and heart failure (HF). Cardiac FKBP12.6 overexpression protects against myocardial infarction-induced HF and catecholamine-promoted vent...
Phosphatase PTEN is critically involved in post-myocardial infarction remodeling through the Akt/interleukin-10 signaling pathway [0.03%]
磷酸酶PTEN通过Akt/白细胞介素10信号途径参与心肌梗死后重构
Nirmal Parajuli,Yuan Yuan,Xiaoxu Zheng et al.
Nirmal Parajuli et al.
The inflammatory cytokines interleukin (IL)-10 and tumor necrosis factor (TNF)-α play an important role in left ventricular (LV) remodeling after myocardial infarction (MI). Phosphatase and tensin homolog deleted on chromosome ten (PTEN) i...
Increased cardiovascular risk in rats with primary renal dysfunction; mediating role for vascular endothelial function [0.03%]
原发性肾功能不全大鼠的心血管风险增加；血管内皮功能的介导作用
M K Szymanski,J H Buikema,D J van Veldhuisen et al.
M K Szymanski et al.
Primary chronic kidney disease is associated with high cardiovascular risk. However, the exact mechanisms behind this cardiorenal interaction remain unclear. We investigated the interaction between heart and kidneys in novel animal model fo...