The effects of curcumin post-treatment against myocardial ischemia and reperfusion by activation of the JAK2/STAT3 signaling pathway [0.03%]
姜黄素通过激活JAK2/STAT3信号途径对心肌缺血再灌注的治疗作用研究
Weixun Duan,Yang Yang,Juanjuan Yan et al.
Weixun Duan et al.
In this study, we evaluated the effect of curcumin (Cur) post-treatment on isolated perfused rat hearts that had been subjected to a protocol of ischemia and reperfusion injury. We also examined whether the Janus kinase 2 and signal transdu...
Genetic suppression of Gαs protein provides rate control in atrial fibrillation [0.03%]
Gαs蛋白基因抑制可提供心房颤动病速率控制
Patrick Lugenbiel,Dierk Thomas,Kamilla Kelemen et al.
Patrick Lugenbiel et al.
Gene therapy-based modulation of atrioventricular (AV) conduction by overexpression of a constitutively active inhibitory Gα(i) protein effectively reduced heart rates in atrial fibrillation (AF). However, catecholamine stimulation caused ...
Remote ischemic preconditioning in cardiac surgery: caught between clinical relevance and statistical significance? [0.03%]
心脏手术中的远程缺血预处理：介于临床意义与统计学意义之间？
Matthias Thielmann
Matthias Thielmann
Exercise-induced cardioprotection is mediated by a bloodborne, transferable factor [0.03%]
运动诱导的心脏保护作用由一种可转移的血液因素介导
M M Michelsen,N B Støttrup,M R Schmidt et al.
M M Michelsen et al.
Exercise protects against myocardial ischemia-reperfusion (I-R) injury but the mechanism remains unclear. Protection can be transferred from a remotely preconditioned human donor to an isolated perfused rabbit heart using a dialysate of pla...
Comparative Study
Basic research in cardiology. 2012 May;107(3):260. DOI:10.1007/s00395-012-0260-x 2012
Derek J Hausenloy,Derek M Yellon
Derek J Hausenloy
Cardiac remodeling is not modulated by overexpression of muscle LIM protein (MLP) [0.03%]
肌肉限蛋白(mlp)的过表达不影响心脏重构
Christian Kuhn,Derk Frank,Franziska Dierck et al.
Christian Kuhn et al.
Muscle LIM protein (MLP) has been proposed to be a central player in the pathogenesis of heart muscle disease. In line with this notion, the homozygous loss of MLP results in cardiac hypertrophy and dilated cardiomyopathy. Moreover, MLP is ...
Inhibition of STAT3 signaling prevents vascular smooth muscle cell proliferation and neointima formation [0.03%]
STAT3信号传导的抑制可防止血管平滑肌细胞增殖和新生内膜形成
Jan-Marcus Daniel,Jochen Dutzmann,Wiebke Bielenberg et al.
Jan-Marcus Daniel et al.
Dedifferentiation, migration, and proliferation of resident vascular smooth muscle cells (SMCs) are key components of neointima formation after vascular injury. Activation of signal transducer and activator of transcription-3 (STAT3) is sug...
A pilot study investigating the effects of remote ischemic preconditioning in high-risk cardiac surgery using a randomised controlled double-blind protocol [0.03%]
采用随机双盲法调查远程缺血预处理在高危心脏手术中效果的研究
Paul Jeffrey Young,Paul Dalley,Alexander Garden et al.
Paul Jeffrey Young et al.
The efficacy of remote ischemic preconditioning (RIPC) in high-risk cardiac surgery is uncertain. In this study, 96 adults undergoing high-risk cardiac surgery were randomised to RIPC (3 cycles of 5 min of upper-limb ischemia induced by inf...
Clinical Trial
Basic research in cardiology. 2012 May;107(3):256. DOI:10.1007/s00395-012-0256-6 2012
Live monitoring of small vessels during development and disease using the flt-1 promoter element [0.03%]
利用flt-1启动子元件在发育和疾病过程中对小型血管的实时监测
Katia Herz,Jan C Heinemann,Michael Hesse et al.
Katia Herz et al.
Vessel formation is of critical importance for organ function in the normal and diseased state. In particular, the labeling and quantitation of small vessels prove to be technically challenging using current approaches. We have, therefore, ...
Left atrium of the human adult heart contains a population of side population cells [0.03%]
人成人心脏左心房中含有一群侧群细胞
Joakim Sandstedt,Marianne Jonsson,Kristina Kajic et al.
Joakim Sandstedt et al.
Cardiac "side population" (SP) cells have previously been found to differentiate into both endothelial cells and cardiomyocytes in mice and rats, but there are no data on SP cells in the human adult heart. Therefore, human cardiac atrial bi...