Myocardial phosphoproteomics unveils a key role of DYRK1A in aortic valve replacement-induced reverse remodelling [0.03%]
磷酸化蛋白质组学揭示DYRK1A在主动脉瓣置换术诱导的心肌逆向重塑中的关键作用
Fábio Trindade,João Almeida-Coelho,Cláudia Sousa-Mendes et al.
Fábio Trindade et al.
Aortic valve stenosis (AVS) is a growing healthcare burden. Aortic valve replacement (AVR) remains the only effective treatment to eliminate pressure overload and triggers myocardial reverse remodelling (RR), with regression of hypertrophy,...
Pericardial adipose tissue promotes transition to heart failure with reduced ejection fraction upon pressure-overload in mice [0.03%]
压力超负荷下心包脂肪组织促进小鼠射血分数降低型心力衰竭的进展
Yi Xuan Shia,Kathleen Pappritz,Anna Cristina Kaltenbach et al.
Yi Xuan Shia et al.
In patients, severity of pressure-induced heart failure (HF) due to aortic stenosis and metabolic disorder correlates with thickness and mass of epicardial adipose tissue (EAT). We examined the role of the less studied pericardial adipose t...
A macrophage gene-regulatory network linked to clinical severity of coronary artery disease : The STARNET and NGS-PREDICT primary blood macrophage studies [0.03%]
与冠状动脉疾病临床严重程度相关的巨噬细胞基因调控网络：STARNET和NGS-PREDICT初级血液巨噬细胞研究
Lijiang Ma,Jacqueline E Tamis-Holland,Giuseppe Mocci et al.
Lijiang Ma et al.
Coronary artery disease (CAD) is a major cause of global morbidity and mortality. Macrophages play a central role in orchestrating this disease process. In 2016, we initiated the STARNET primary blood macrophage study, followed by the multi...
Potassium as an electro-metabolic signal for local coronary vasodilation [0.03%]
钾作为冠状动脉局部血管扩张的电代谢信号
Johnathan D Tune,Dirk J Duncker,Adam G Goodwill et al.
Johnathan D Tune et al.
This study tested the hypothesis that K+ serves as an in vivo signal coupling coronary blood flow with the oxidative requirements of the myocardium. Experiments were performed in swine in which coronary parameters and arterial and coronary ...
The innate immune receptor NLRX1 is a novel required modulator for mPTP opening: implications for cardioprotection [0.03%]
NLRX1是线粒体 permeability transition pore开放的新上游效应分子：对心肌保护的启示
Y Xiao,X Hu,C F Rudolphi et al.
Y Xiao et al.
NLRX1 is the only NOD-like innate immune receptor that localises to mitochondria. We previously demonstrated that NLRX1 deletion increased infarct size in isolated mouse hearts subjected to ischemia-reperfusion injury (IRI); however, underl...
Antimicrobial peptide CRAMP/LL-37 mediates ferroptosis resistance in cardiomyocytes by inhibiting cathepsin L [0.03%]
抗菌肽CRAMP/LL-37通过抑制猫良蛋白L介导心肌细胞抗铁死亡作用
Zhantao Liu,Qingsong Zhang,Dan Su et al.
Zhantao Liu et al.
Ferroptosis is an important cause of cardiomyocyte loss and cardiac dysfunction. Cathelicidin-related antimicrobial peptide (CRAMP) is an endogenous polypeptide that regulates oxidative stress in the body and is involved in ferroptosis. How...
Molecular screening in a translational large animal trial identifies a differential inflammatory response for MINOCA [0.03%]
分子筛选在转化大型动物试验中发现MINOCA的差异性炎症反应
Jasper Iske,Joshua M Mesfin,Petra Wolint et al.
Jasper Iske et al.
Myocardial infarction without obstructive coronary arteries (MINOCA) comprises up to 15% of all myocardial infarctions (MI) and could be caused by cardiac microembolization (CME) originating from plaque rupture and/or erosion. Early diagnos...
Direction-dependent contributions of cardiac myofilament networks to myocardial passive stiffness reveal a major disparity for titin [0.03%]
心脏肌丝网络对心肌被动僵硬的贡献具有方向依赖性，揭示了titin的主要差异
Felix A Wagner,Christine M Loescher,Andreas Unger et al.
Felix A Wagner et al.
Progressive myocardial dysfunction in patients with heart failure often involves alterations in myocardial passive stiffness, yet the underlying mechanisms remain incompletely understood. While passive stiffness in the longitudinal directio...
Anti-inflammatory interventions in coronary artery disease: antipodal responses requiring targeted therapeutic strategies [0.03%]
冠心病的抗炎干预：需要针对性治疗策略的矛盾反应
Konstantinos Iliodromitis,Melchior Seyfarth,Zsuzsanna Balogh et al.
Konstantinos Iliodromitis et al.
Inflammation has a key role in coronary atherosclerotic disease (CAD), as it contributes to the development, progression, instability and rupture of the atherosclerotic plaque. The long-term treatment and continuous suppression of inflammat...
Giuseppe Cipriano,Thomas Thum,Natalie Weber
Giuseppe Cipriano
Ischemic heart disease is one of the leading causes of heart failure and death worldwide. The loss of cardiomyocytes following a myocardial infarction drives the remodeling process, which, in most cases, ultimately leads to heart failure. S...