Calcific aortic valve disease augments vesicular microRNA-145-5p to regulate the calcification of valvular interstitial cells via cellular crosstalk [0.03%]
钙化主动脉瓣疾病通过细胞通讯增强囊泡miR-145-5p来调节瓣膜间质细胞的钙化
P R Goody,D Christmann,D Goody et al.
P R Goody et al.
Calcific aortic valve disease (CAVD) is one of the leading causes of cardiovascular death in the elderly population worldwide. MicroRNAs (miRNAs) are highly dysregulated in patients with CAVD undergoing surgical aortic valve replacement (SA...
Alpha-ketoglutarate protects against myocardial infarction via FTO-mediated anti-inflammatory macrophage activation [0.03%]
α-酮戊二酸通过FTO介导的抗炎巨噬细胞活化保护心肌梗死
Zhijun Lin,Huan He,Pinliang Chen et al.
Zhijun Lin et al.
Ischemic heart disease lacks optimal therapies targeting post-infarction inflammation and remodeling. The role of TCA cycle metabolites in modulating macrophage-driven cardiac inflammation remains unclear. This study hypothesized that AKG s...
The influence of acute and chronic coronary syndrome on the gut microbiome and downstream microbiome-derived metabolites-Microbiome in acute myocardial infarction-MIAMI-Trial [0.03%]
急性及慢性冠状动脉综合征对肠道微生物群及其下游代谢产物的影响-急性心肌梗死中的微生物组：MIAMI试验
Daniel Messiha,Erik Lange,Annika Tratnik et al.
Daniel Messiha et al.
Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in the industrialized world. The gut microbiome influences CVD, through atherogenic metabolites like trimethylamine N-oxide (TMAO) or protective effects through ...
Benedikt Bartsch,Raúl Nicolas Jamin,Axel Schott et al.
Benedikt Bartsch et al.
Infective endocarditis (IE) is a highly lethal disease with a notable male predominance, yet the biological basis for this sex disparity remains unclear. We established a murine IE model in C57BL6 mice in which aortic valve injury was induc...
Attenuation of myocardial ischemia-reperfusion injury in mice through CD80/86 deficiency: improved microvascular obstruction via reduced macrophage and T lymphocyte infiltration [0.03%]
通过CD80 / 86缺陷减弱小鼠的心肌缺血再灌注损伤：通过减少巨噬细胞和T淋巴细胞浸润改善微血管阻塞
Lu Liu,Xiao-Xiao Wang,Si-Xue Wang et al.
Lu Liu et al.
Microvascular obstruction (MVO) is a fundamental mechanism underlying the occurrence of no-reflow, which contributes to myocardial ischemia-reperfusion injury (MI/RI). Despite its significance, the precise pathophysiology of MVO remains inc...
Cold storage of mouse hearts prior to cardiomyocyte isolation preserves electromechanical function, microstructure, and gene expression for 24 h [0.03%]
冷存储可使小鼠心脏在分离心肌细胞前后24小时内保持电机械功能、微结构和基因表达
Benedikt Pfeilschifter,Aiora Martinez-Vilchez,Zafar Iqbal et al.
Benedikt Pfeilschifter et al.
Isolation of myocytes from mouse hearts, especially of transgenic animals or disease models, is crucial in cardiac research. The presumption that cardiomyocytes must be isolated immediately after heart procurement to avoid deterioration imp...
H2O2-mediated relaxation in a swine model of ischemic heart disease and exercise training: mechanistic insights and the role of Kv7 channels [0.03%]
过氧化氢介导的缺血性心脏病和运动训练猪模型中的血管松弛：机制见解及Kv7通道的作用
T S Self,J F Bray,C L Heaps
T S Self
We previously reported that H2O2-mediated arteriolar dilation impaired by chronic occlusion is corrected with exercise training and that BKCa and Kv channels both contribute to these adaptations. To gain additional understanding of the spec...
AAV-mediated overexpression of CPT1B protects from cardiac hypertrophy and heart failure in a murine pressure overload model [0.03%]
AAV介导的CPT1B过表达在小鼠压力超负荷模型中预防心肌肥厚和心力衰竭
Anca Kliesow Remes,Theresa Ruf,Tinatin Zurashvili et al.
Anca Kliesow Remes et al.
The transition from cardiac hypertrophy to heart failure is characterized by metabolic changes like downregulation of fatty acid metabolism in favor of increased glucose utilization. Carnitine palmitoyltransferase 1B (CPT1B) catalyzes the r...
Sonogenetic neuromodulation prevents post-myocardial infarction malignant arrhythmia and cardiac remodeling through the brain-heart circuit [0.03%]
脑心通路介导的声光遗传抗心肌梗死后恶性心律失常及心脏重构
Haoyuan Hu,Changhao Hu,Xueqin Cheng et al.
Haoyuan Hu et al.
Sympathetic hyperactivation within the paraventricular nucleus (PVN) exacerbates post-myocardial infarction (MI) malignant ventricular arrhythmias (VAs) and cardiac remodeling. Sonogenetics is an emerging reversible neuromodulation, which m...
The activation of catecholamine neurons in the rostral ventrolateral medulla drives ventricular remodeling after myocardial ischemia/reperfusion injury [0.03%]
喉侧腹外侧延髓去甲肾上腺素能神经元的激活参与心肌缺血再灌注损伤后的心室重构事件
Shijin Xu,Rui Zhang,Shiyun Jin et al.
Shijin Xu et al.
Catecholamine neurons in the rostral ventrolateral medulla (RVLM) have long been recognized as a crucial neuronal population involved in cardiovascular regulation. However, its function and related circuits in ventricular remodeling after m...