Mixed lineage kinase 3 contributes to myocardial ischemia/reperfusion injury by regulating neutrophil activation [0.03%]
混合谱系激酶3通过调节中性粒细胞活化参与心肌缺血再灌注损伤
Zilong Xiao,Xiang Wei,Zhonglei Xie et al.
Zilong Xiao et al.
Mixed lineage kinase 3 (MLK3), a member of the MAP3K family, is known to participate in cellular stress and inflammatory responses, but its role in neutrophil-mediated myocardial ischemia-reperfusion (I/R) injury remains unclear. In this st...
Correction: IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): a small animal acute myocardial infarction randomized-controlled multicenter study on the effect of ischemic preconditioning [0.03%]
纠正：改进心肌保护性疗法的临床前评估（IMPACT）：一项关于缺血前 conditioning影响的小型动物急性心肌梗死多中心随机对照研究
Sauri Hernandez-Resendiz,Reinis Vilskersts,David Aluja et al.
Sauri Hernandez-Resendiz et al.
Published Erratum
Basic research in cardiology. 2025 Nov 10. DOI:10.1007/s00395-025-01142-9 2025
Single cell and spatial transcriptomic profiling of the type 2 diabetic coronary microcirculation and myocardium [0.03%]
单细胞和空间转录组揭示2型糖尿病冠脉微循环与心肌的病理特征
Patricia E McCallinhart,Corinne H Strawser,Elizabeth A R Garfinkle et al.
Patricia E McCallinhart et al.
Coronary microvascular disease (CMD) is an early complication of type 2 diabetes (T2D) involving adverse endothelial and smooth muscle function, vascular remodeling, and alterations in mechanics. These culminate in impaired coronary blood f...
The role of NO, H2O2, and non-NO/H2O2 mechanisms in acetylcholine (ACh)-induced dilation of human arterioles in the absence and presence of coronary artery disease [0.03%]
无冠心病及有冠心病时乙酰胆碱(ACh)诱导人冠状动脉阻力小血管舒张的机理研究：一氧化氮、过氧化氢及其他途径的作用
Kostiantyn Drachuk,Yoshinori Nishijima,Aravind Parthasarathy et al.
Kostiantyn Drachuk et al.
This study defines the mechanisms of vasodilation to acetylcholine (ACh) in arterioles from patients with and without coronary artery disease (CAD). Human adipose arterioles (HAA) dissected from discarded surgical samples were cannulated an...
Chemokine-receptor-guided B-cell immunity in cardiovascular disease [0.03%]
趋化因子受体指导的B细胞免疫在心血管疾病中的作用
Anais Yerly,Emiel P C van der Vorst,Marc Schindewolf et al.
Anais Yerly et al.
Cardiovascular diseases (CVD) include a wide range of disorders affecting the heart and blood vessels, many of which are associated with atherosclerosis. Atherosclerosis is the main underlying cause of CVDs and represents a chronic inflamma...
The CNP analogue vosoritide mediates PDE2-sensitive anti-arrhythmogenic effects in mouse hearts with STZ-induced type 1 diabetes [0.03%]
CNP类似物vosoritide介导了在链脲佐菌素诱导的1型糖尿病小鼠心脏中的PDE2敏感的抗心律失常效应
Rebecca Firneburg,Katharina Tergau,Eleder Cachorro et al.
Rebecca Firneburg et al.
Diabetes mellitus induces adverse structural, electrophysiological and autonomic remodelling increasing the risk for life-threatening arrhythmias, particularly after acute myocardial infarction. Natriuretic peptides (NPs) show increasing ev...
Downregulation of TCF19 and ATAD2 causes endothelial cell cycle arrest at the transition from cardiac hypertrophy to heart failure [0.03%]
TCF19和ATAD2表达下调导致心脏肥大向心力衰竭进展过程中心肌内皮细胞周期阻滞
Elias Erny,Christoph Koentges,Debanjan Mukherjee et al.
Elias Erny et al.
Cardiac hypertrophy is a key mechanism that allows the heart to adapt to increased load, but in the long term is associated with a higher risk for heart failure, arrhythmia, and death. During hypertrophic growth, cardiac myocytes signal to ...
Renal denervation attenuates cardiac dysfunction in HFpEF by inhibiting the ATP-P2X7-NLRP3 inflammasome axis [0.03%]
肾去神经支配通过抑制ATP-P2X7-NLRP3炎性小体轴缓解HFpEF心脏功能障碍
Zhuqing Li,Xiaoqiang Sun,Yanxin Wang et al.
Zhuqing Li et al.
Heart failure with preserved ejection fraction (HFpEF) arises from intersecting comorbidities involving inflammation, metabolic stress, and sympathetic nervous system (SNS) activation. To mirror this complexity, we established a clinically ...
NLRP3 mediates lipid-driven macrophage proliferation in established atherosclerosis [0.03%]
NLRP3介导脂质驱动的动脉粥样硬化中成熟巨噬细胞增殖
Carmen Härdtner,Felix Remmersmann,Carolin Ehlert et al.
Carmen Härdtner et al.
An increased number of macrophages in the atherosclerotic plaque is associated with plaque instability and plaque progression. Lowering systemic cholesterol levels suppresses local macrophage proliferation and leads to plaque regression. Ho...
Cardiac sodium-glucose co-transporter 1 (SGLT1) contributes to heart failure in a mouse model of diabetic cardiomyopathy [0.03%]
心脏钠葡萄糖共转运蛋白1(SGLT1)参与糖尿病心肌病小鼠模型中心力衰竭的发展
Zhao Li,Sydney Freiberg,Meredith L Music et al.
Zhao Li et al.
Diabetes mellitus can lead to a cardiomyopathy independent of other risk factors such as coronary artery disease and hypertension, in up to 75% of patients. The prevalence of diabetic cardiomyopathy in the population is 1.1%. We previously ...