Peripheral chemoreceptors sustain central chemoreflex potentiation and cardiorespiratory abnormalities in high-output heart failure [0.03%]
外周化学感受器维持高输出量心力衰竭中的中枢化学反射亢进及心血管呼吸异常现象
Katherin V Pereyra,Karla G Schwarz,Esteban Diaz-Jara et al.
Katherin V Pereyra et al.
Central chemoreflex activation worsens cardiorespiratory dysfunction in high-output heart failure (HO-HF). Recently, interdependence between both peripheral and central chemoreceptors has been linked to alterations in cardiorespiratory regu...
From kidney injury to cardiac dysfunction: the central role of oxidative stress in diabetes and CKD [0.03%]
从肾脏损伤到心脏功能障碍：糖尿病和CKD中氧化应激的中心作用
Payel Sen,Theresa Sittig,Jules Hamers et al.
Payel Sen et al.
Both diabetes mellitus (DM) and chronic kidney disease (CKD) predispose to cardiac remodeling and coronary microvascular dysfunction, which is proposed to be mediated through increased oxidative stress. To link oxidative stress and cardiac ...
Treadmill exercise activates mechanosensitive Piezo1 to inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction in mice [0.03%]
跑步机运动通过活化Piezo1来抑制心肌梗死后的心肌细胞凋亡及改善心脏功能
Xinyan Duan,Renhan Liu,Yifei Zhao et al.
Xinyan Duan et al.
The cardioprotective mechanisms through which the heart directly senses exercise remain incompletely defined. In this study, wild-type C57BL/6J and cardiomyocyte-specific Piezo1 knockdown mice were subjected to myocardial infarction (MI) an...
NLGN3 contributes to angiogenesis in myocardial infarction via activation of the Gαi1/3-Akt pathway [0.03%]
NLGN3通过激活Gαi1/3-Akt途径促进心肌梗死后血管生成
Shunsong Qiao,Chao Tang,Dantian Zhan et al.
Shunsong Qiao et al.
Angiogenesis is an important repair mechanism for myocardial infarction. Neuroligin-3 (NLGN3) can promote angiogenesis by activating Gαi1/3-Akt signaling following ischemic brain injury. This study investigated the role of NLGN3 in myocard...
Coronary microvascular dysfunction is a determinant of perfusion-contraction matching during ischemia [0.03%]
心肌微血管功能障碍决定缺血期间灌注收缩匹配性
John M Canty Jr,Brian R Weil
John M Canty Jr
Dysfunctional high-density lipoprotein particles are associated with cardiac alterations in cancer patients and tumor-bearing mice receiving doxorubicin [0.03%]
功能异常的高密度脂蛋白颗粒与癌症患者和接受多柔比星治疗的携带肿瘤的小鼠心脏变化有关
Carmelita Abrahams,Wanzhu Zhang,Nonhlakanipho Sangweni et al.
Carmelita Abrahams et al.
Cancer patients receiving doxorubicin (DOX) chemotherapy are at high risk of developing cardiac alterations, but the mechanisms remain elusive. Both breast cancer and DOX therapy are associated with dyslipidemia. We aimed to investigate whe...
Luo Liu,Rongling Wang,Stefano Strocchi et al.
Luo Liu et al.
Heart failure with preserved ejection fraction (HFpEF) accounts for more than half of all heart failure cases, and its prevalence is projected to rise further. Among its heterogeneous subtypes, cardiometabolic HFpEF, which is driven by meta...
Mechanical unloading coupled with coronary reperfusion stimulates cardiomyocyte proliferation and prevents unloading-induced fibrosis after myocardial infarction [0.03%]
心肌梗死后机械卸载联合冠状动脉再灌注可刺激心肌细胞增殖并防止卸载诱导的纤维化
Sean O Bello,Charanjit Singh,Filippo Perbellini et al.
Sean O Bello et al.
Percutaneous left ventricular assist devices (LVADs) have become essential tools during coronary reperfusion in high-risk PCI. Significant reduction in infarct propagation is observed when mechanical unloading is coupled with reperfusion, b...
Impairment of local metabolic coronary control involves perfusion-contraction matching not supply-demand imbalance [0.03%]
局部代谢性冠状动脉控制功能障碍涉及灌注收缩匹配而不是供应需求不平衡
Salman I Essajee,Gregory M Dick,Selina M Tucker et al.
Salman I Essajee et al.
Understanding of local metabolic control of coronary flow remains stifled by debate around data interpretation and anticipated outcomes. To address this question we performed experiments in a cannulated coronary preparation in swine to prec...
Autophagy modulates the mechanism of flow-mediated dilation upstream of telomerase [0.03%]
自噬通过调控端粒酶上游机制调节流介导的血管舒张功能
William E Hughes,Shelby N Hader,Kate Astbury et al.
William E Hughes et al.
The non-canonical functions of telomerase reverse transcriptase (TERT), the catalytic subunit of telomerase play a critical role in maintaining microvascular homeostasis utilizing both human and rodent models. Previously, we have demonstrat...