Brain natriuretic peptide protects against acute pulmonary embolism-induced pulmonary vasoconstriction through natriuretic peptide receptor C [0.03%]
脑钠肽通过钠尿肽受体C对抗急性肺栓塞引起的肺血管收缩作用
Yizhuo Gao,Shiqi Liu,Zhichun Gu et al.
Yizhuo Gao et al.
Acute pulmonary embolism (PE) remains a leading cause of cardiovascular mortality, driven primarily by a sudden increase in pulmonary artery (PA) resistance. Brain Natriuretic Peptide (BNP) may hold promise for reducing PA resistance. Howev...
Artery tertiary lymphoid organs, neuro-immune interaction and their mediators in atherosclerosis [0.03%]
动脉三级淋巴器官、神经免疫相互作用及其在动脉粥样硬化中的介质
Silvia Ortona,Caterina Ivaldo,Luca Liberale et al.
Silvia Ortona et al.
Atherosclerosis is a chronic inflammatory disease characterized by the irreversible remodeling of the arterial wall; severe atherosclerotic lesions may lead to life-threatening consequences such as major ischemic events (i.e., myocardial in...
Amyloid beta 42 disrupts cardiac function in Alzheimer's disease mice via SLC31A1 upregulation-mediated cuproptosis [0.03%]
通过SLC31A1上调介导的铜依赖性细胞死亡(cuproptosis)APP/PS1小鼠中淀粉样蛋白β42扰乱心脏功能
Wenjun Xiong,Zikang Luo,Hong Wang et al.
Wenjun Xiong et al.
Background Alzheimer's disease (AD) is a complex systemic disorder that extends beyond the central nervous system, exerting pathological effects on the heart. Epidemiological studies have consistently shown that individuals with AD often ex...
Melatonin and mitochondrial protection in cardiac ischemia-reperfusion injury: mechanisms, evidence and translational perspectives [0.03%]
褪黑素与心肌缺血再灌注损伤线粒体保护：机制、证据和转化前景
Gaia Pedriali,Sara Leo,Margherita Tiezzi et al.
Gaia Pedriali et al.
Cardiac ischemia-reperfusion injury (IRI) leads to significant mitochondrial impairment, which contributes to cell death and hampers myocardial recovery. During IRI, mitochondria are subjected to oxidative stress, calcium overload, and alte...
Remote ischemic conditioning protects against anthracycline cardiotoxicity without impairing its antitumor activity [0.03%]
远程缺血适应可防治蒽环类药物心脏毒性而不影响其抗肿瘤活性
Anabel Díaz-Guerra,Agustín Clemente-Moragón,Ángela Pollán et al.
Anabel Díaz-Guerra et al.
Anthracyclines remain a cornerstone of treatment for many cancer types; however, their cardiotoxic potential leads to cardiac dysfunction in a substantial proportion of patients, ultimately compromising long-term quality of life. Few strate...
Remote ischemic conditioning for safe cardioprotection in cardio-oncology? [0.03%]
心肌缺血处置在心血管肿瘤学中的作用？
Matthias Totzeck,Tienush Rassaf
Matthias Totzeck
Cardiac lymphatics: functional plasticity in development, disease, and precision-targeted therapies [0.03%]
心脏淋巴系统：发育、疾病和精确诊疗的功能可塑性
Liang Hao,Bai-Qiang Li,Fu-Ying Zhao et al.
Liang Hao et al.
The cardiac lymphatic system plays a crucial role in maintaining myocardial homeostasis by regulating fluid equilibrium, immune surveillance, and metabolite clearance. This review highlights recent advances in understanding its development,...
miR-144 targets in myocardial hypertrophy and coronary microvascular dysfunction in hypertrophic cardiomyopathy: molecular research meets imaging [0.03%]
靶向微小核糖核酸-144对肥厚型心肌病心肌肥厚及冠状微血管功能障碍的分子影像学研究
Maria Lombardi,Monica Barki,Lucia Spartano et al.
Maria Lombardi et al.
Aims: Hypertrophic cardiomyopathy (HCM) is characterized by left ventricular hypertrophy, diastolic dysfunction and coronary microvascular dysfunction (CMD). The microRNA-144-3p (miR-144) has recently emerged as a player ...
Myocardial ischemia: no supply/demand mismatch but reduced blood flow per beat [0.03%]
心肌缺血：不是供氧和需氧不匹配而是每次心跳的血流量减少
Gerd Heusch
Gerd Heusch
The views on myocardial ischemia are changing-with an increasing focus on plaque vulnerability in acute coronary syndromes and more attention to the coronary microcirculation in chronic coronary syndromes. The unifying paradigm of supply/de...
Pathological mechanisms and treatment strategies for immune checkpoint inhibitor-associated myocarditis: insights from single-cell sequencing [0.03%]
基于单细胞测序的免疫检查点抑制剂相关心肌炎病理机制及治疗策略探讨
Yameng Zhao,Yang Lu,Tinglan Fu et al.
Yameng Zhao et al.
Immune checkpoint inhibitors have significantly advanced cancer treatment, but they can lead to immune-related adverse events. Among these, immune checkpoint inhibitor-associated myocarditis (ICI-M) represents a rare yet severe cardiotoxici...