Gasotransmitters and noble gases in cardioprotection: unraveling molecular pathways for future therapeutic strategies [0.03%]
气体信使和惰性气体在心脏保护中的作用：揭示分子通路以供未来治疗策略参考
Pasquale Pagliaro,Nina C Weber,Saveria Femminò et al.
Pasquale Pagliaro et al.
Despite recent progress, ischemic heart disease poses a persistent global challenge, driving significant morbidity and mortality. The pursuit of therapeutic solutions has led to the emergence of strategies such as ischemic preconditioning, ...
Malonate given at reperfusion prevents post-myocardial infarction heart failure by decreasing ischemia/reperfusion injury [0.03%]
缺血再灌注损伤减少门冬氨酸转移酶心肌梗死后缺血再灌注损伤减少可预防心力衰竭
Jiro Abe,Ana Vujic,Hiran A Prag et al.
Jiro Abe et al.
The mitochondrial metabolite succinate is a key driver of ischemia/reperfusion injury (IRI). Targeting succinate metabolism by inhibiting succinate dehydrogenase (SDH) upon reperfusion using malonate is an effective therapeutic strategy to ...
Sharif A Sabe,Dwight D Harris,Mark Broadwin et al.
Sharif A Sabe et al.
Since the invention of cardiopulmonary bypass, cardioprotective strategies have been investigated to mitigate ischemic injury to the heart during aortic cross-clamping and reperfusion injury with cross-clamp release. With advances in cardia...
Heart-specific NFAT5 knockout suppresses type I interferon signaling and aggravates coxsackievirus-induced myocarditis [0.03%]
心脏特异性NFAT5敲除抑制I型干扰素信号并加重柯萨奇病毒诱导的心肌炎
Guangze Zhao,Huifang M Zhang,Ali Reza Nasseri et al.
Guangze Zhao et al.
Nuclear factor of activated T cells 5 (NFAT5) is an osmosensitive transcription factor that is well-studied in renal but rarely explored in cardiac diseases. Although the association of Coxsackievirus B3 (CVB3) with viral myocarditis is wel...
Targeting Gαi2 in neutrophils protects from myocardial ischemia reperfusion injury [0.03%]
靶向中性粒细胞Gαi2保护心肌免受缺血再灌注损伤
David Köhler,Veronika Leiss,Lukas Beichert et al.
David Köhler et al.
Neutrophils are not only involved in immune defense against infection but also contribute to the exacerbation of tissue damage after ischemia and reperfusion. We have previously shown that genetic ablation of regulatory Gαi proteins in mic...
Vasodilator reactive oxygen species ameliorate perturbed myocardial oxygen delivery in exercising swine with multiple comorbidities [0.03%]
血管扩张型反应性氧种类改善多合并症运动猪心肌氧气供应紊乱
R W A van Drie,J van de Wouw,L M Zandbergen et al.
R W A van Drie et al.
Multiple common cardiovascular comorbidities produce coronary microvascular dysfunction. We previously observed in swine that a combination of diabetes mellitus (DM), high fat diet (HFD) and chronic kidney disease (CKD) induced systemic inf...
Chronic kidney disease activates the HDAC6-inflammatory axis in the heart and contributes to myocardial remodeling in mice: inhibition of HDAC6 alleviates chronic kidney disease-induced myocardial remodeling [0.03%]
慢性肾病激活小鼠心脏中的HDAC6-炎症轴并促心肌重构：抑制HDAC6可缓解慢性肾脏疾病引起的心肌重构
Sourav Kundu,Shobhit Gairola,Smriti Verma et al.
Sourav Kundu et al.
Chronic kidney disease (CKD) adversely affects the heart. The underlying mechanism and the interplay between the kidney and the heart are still obscure. We examined the cardiac effect using the unilateral ureteral obstruction (UUO)-induced ...
Comparison of the stage-dependent mitochondrial changes in response to pressure overload between the diseased right and left ventricle in the rat [0.03%]
比较压力超负荷下大鼠患病右室和左室线粒体阶段性变化的区别
Ling Li,Bernd Niemann,Fabienne Knapp et al.
Ling Li et al.
The right ventricle (RV) differs developmentally, anatomically and functionally from the left ventricle (LV). Therefore, characteristics of LV adaptation to chronic pressure overload cannot easily be extrapolated to the RV. Mitochondrial ab...
Connexin 43 modulates reverse electron transfer in cardiac mitochondria from inducible knock-out Cx43Cre-ER(T)/fl mice by altering the coenzyme Q pool [0.03%]
Cx43调控Cx43Cre-ER(T)/fl条件性敲除小鼠心脏线粒体反向电子传递的机制：影响辅酶Q池
Marta Consegal,Elisabet Miró-Casas,Ignasi Barba et al.
Marta Consegal et al.
Succinate accumulates during myocardial ischemia and is rapidly oxidized during reperfusion, leading to reactive oxygen species (ROS) production through reverse electron transfer (RET) from mitochondrial complex II to complex I, and favorin...
The role and mechanism of epigenetics in anticancer drug-induced cardiotoxicity [0.03%]
表观遗传在抗肿瘤药物诱导的心脏毒性中的作用和机制研究
Xuening Liu,Zijian Li
Xuening Liu
Cardiovascular disease is the main factor contributing to the global burden of diseases, and the cardiotoxicity caused by anticancer drugs is an essential component that cannot be ignored. With the development of anticancer drugs, the survi...