Recombinant human placental growth factor-2 in post-infarction left ventricular dysfunction: a randomized, placebo-controlled, preclinical study [0.03%]
重组人胎盘生长因子-2在心梗后左室功能障碍中的应用：一项随机、安慰剂对照的临床前研究
Ming Wu,Peter Pokreisz,Piet Claus et al.
Ming Wu et al.
Placental growth factor (PlGF)-2 induces angio- and arteriogenesis in rodents but its therapeutic potential in a clinically representative post-infarction left ventricular (LV) dysfunction model remains unclear. We, therefore, investigated ...
SGLT1 contributes to glucose-mediated exacerbation of ischemia-reperfusion injury in ex vivo rat heart [0.03%]
SGLT1参与葡萄糖介导的离体大鼠心脏缺血再灌注损伤恶化
Alhanoof Almalki,Sapna Arjun,Idris Harding et al.
Alhanoof Almalki et al.
Hyperglycaemia is common during acute coronary syndromes (ACS) irrespective of diabetic status and portends excess infarct size and mortality, but the mechanisms underlying this effect are poorly understood. We hypothesized that sodium/gluc...
Empagliflozin prevents heart failure through inhibition of the NHE1-NO pathway, independent of SGLT2 [0.03%]
恩格列净通过抑制NHE1-NO通路预防心力衰竭 独立于SGLT2抑制作用之外
Sha Chen,Qian Wang,Diane Bakker et al.
Sha Chen et al.
Sodium glucose cotransporter 2 inhibitors (SGLT2i) constitute the only medication class that consistently prevents or attenuates human heart failure (HF) independent of ejection fraction. We have suggested earlier that the protective mechan...
Preclinical models of cardiotoxicity from immune checkpoint inhibitor therapy [0.03%]
免疫检查点抑制剂治疗的心脏毒性前期模型
Florian Buehning,Tobias Lerchner,Julia Vogel et al.
Florian Buehning et al.
Immune checkpoint inhibitor (ICI) therapy represents a ground-breaking paradigm in cancer treatment, harnessing the immune system to combat malignancies by targeting checkpoints such as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) a...
Molecular fingerprints of cardiovascular toxicities of immune checkpoint inhibitors [0.03%]
免疫检查点抑制剂心血管毒性的分子特征研究
Tamás G Gergely,Zsófia D Drobni,Nabil V Sayour et al.
Tamás G Gergely et al.
Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy by unleashing the power of the immune system against malignant cells. However, their use is associated with a spectrum of adverse effects, including cardiovascular compl...
The attenuated hepatic clearance of propionate increases cardiac oxidative stress in propionic acidemia [0.03%]
丙酸血症时丙酸肝清除率下降致心脏氧化应激水平增加
You Wang,Suhong Zhu,Wentao He et al.
You Wang et al.
Propionic acidemia (PA), arising from PCCA or PCCB variants, manifests as life-threatening cardiomyopathy and arrhythmias, with unclear pathophysiology. In this work, propionyl-CoA metabolism in rodent hearts and human pluripotent stem cell...
Bone marrow cells contribute to seven different endothelial cell populations in the heart [0.03%]
骨髓细胞分化形成心脏内的七种不同的内皮细胞群
Parisa Shabani,Vahagn Ohanyan,Ammar Alghadeer et al.
Parisa Shabani et al.
Understanding the mechanisms underlying vascular regeneration in the heart is crucial for developing novel therapeutic strategies for myocardial ischemia. This study investigates the contribution of bone marrow-derived cells to endothelial ...
Sodium-glucose cotransporter 2 inhibitors and the cancer patient: from diabetes to cardioprotection and beyond [0.03%]
钠-葡萄糖共转运蛋白2抑制剂与癌症患者：从糖尿病到心脏保护等其他方面的作用
Massimiliano Camilli,Marcello Viscovo,Luca Maggio et al.
Massimiliano Camilli et al.
Sodium-glucose cotransporter 2 inhibitors (SGLT2i), a new drug class initially designed and approved for treatment of diabetes mellitus, have been shown to exert pleiotropic metabolic and direct cardioprotective and nephroprotective effects...
Increased [18F]FDG uptake in the infarcted myocardial area displayed by combined PET/CMR correlates with snRNA-seq-detected inflammatory cell invasion [0.03%]
[18F]FDG正电子发射断层扫描/磁共振成像显示的心肌梗死区摄取增加与单核细胞RNA测序检测到的炎症细胞浸润相关
Dominika Lukovic,Mariann Gyöngyösi,Imre J Pavo et al.
Dominika Lukovic et al.
Combined [18F]FDG PET-cardiac MRI imaging (PET/CMR) is a useful tool to assess myocardial viability and cardiac function in patients with acute myocardial infarction (AMI). Here, we evaluated the prognostic value of PET/CMR in a porcine clo...
Mitochondrial calcium in cardiac ischemia/reperfusion injury and cardioprotection [0.03%]
心肌缺血/再灌注损伤和心肌保护中的线粒体钙离子动态变化
Edoardo Bertero,Tudor-Alexandru Popoiu,Christoph Maack
Edoardo Bertero
Mitochondrial calcium (Ca2+) signals play a central role in cardiac homeostasis and disease. In the healthy heart, mitochondrial Ca2+ levels modulate the rate of oxidative metabolism to match the rate of adenosine triphosphate consumption i...