Adriana E Viñas-Mendieta,Andrea Gallardo-Grajeda,Teresa López-Fernández
Adriana E Viñas-Mendieta
Cardio-oncology is an emerging field that aims to ensure optimal cancer treatment while minimising cardiovascular toxicity. The management of cardiovascular toxicity is critical because it can lead to premature discontinuation of treatment,...
Deep learning segmentation model for quantification of infarct size in pigs with myocardial ischemia/reperfusion [0.03%]
用于心肌缺血/再灌注猪心梗面积定量的深度学习分割模型
Felix Braczko,Andreas Skyschally,Helmut Lieder et al.
Felix Braczko et al.
Infarct size (IS) is the most robust end point for evaluating the success of preclinical studies on cardioprotection. The gold standard for IS quantification in ischemia/reperfusion (I/R) experiments is triphenyl tetrazolium chloride (TTC) ...
Single-cell transcriptomics reveal distinctive patterns of fibroblast activation in heart failure with preserved ejection fraction [0.03%]
单细胞转录组揭示射血分数保留心力衰竭成纤维细胞激活的独特模式
Jan D Lanzer,Laura M Wienecke,Ricardo O Ramirez Flores et al.
Jan D Lanzer et al.
Inflammation, fibrosis and metabolic stress critically promote heart failure with preserved ejection fraction (HFpEF). Exposure to high-fat diet and nitric oxide synthase inhibitor N[w]-nitro-l-arginine methyl ester (L-NAME) recapitulate fe...
Markus S Anker,Ahmed Mustafa Rashid,Javed Butler et al.
Markus S Anker et al.
Patients with cancer face a significant risk of cardiovascular death, regardless of time since cancer diagnosis. Elderly patients are particularly more susceptible as cancer-associated cardiac complications present in advanced stage cancer....
Andrea Moreno-Arciniegas,Laura Cádiz,Carlos Galán-Arriola et al.
Andrea Moreno-Arciniegas et al.
Thanks to the fantastic progress in cancer therapy options, there is a growing population of cancer survivors. This success has resulted in a need to focus much effort into improving the quality of life of this population. Cancer and cardio...
Immuno-related cardio-vascular adverse events associated with immuno-oncological treatments: an under-estimated threat for cancer patients [0.03%]
与免疫治疗相关的免疫性心血管不良事件：对癌症患者的潜在威胁
Giuseppe Panuccio,Pierpaolo Correale,Maria d&#x;Apolito et al.
Giuseppe Panuccio et al.
Immunotherapy represents an emergent and heterogeneous group of anticancer treatments harnessing the human immune-surveillance system, including immune-checkpoint inhibitor monoclonal antibodies (mAbs), Chimeric Antigen Receptor T Cells (CA...
Cardioprotection of voluntary exercise against breast cancer-induced cardiac injury via STAT3 [0.03%]
运动保护心脏免受乳腺癌引起的心脏损伤的机制研究——STAT3信号通路的作用
Lan Wu,Zhi-Zheng Li,Hao Yang et al.
Lan Wu et al.
Exercise is an effective way to alleviate breast cancer-induced cardiac injury to a certain extent. However, whether voluntary exercise (VE) activates cardiac signal transducer and activator of transcription 3 (STAT3) and the underlying mec...
β3-Adrenergic receptor overexpression in cardiomyocytes preconditions mitochondria to withstand ischemia-reperfusion injury [0.03%]
心肌细胞中过表达的β3肾上腺素能受体使线粒体适应缺血再灌注损伤
Miguel Fernández-Tocino,Andrés Pun-Garcia,Mónica Gómez et al.
Miguel Fernández-Tocino et al.
β3-Adrenergic receptor (β3AR) agonists have been shown to protect against ischemia-reperfusion injury (IRI). Since β3ARs are present both in cardiomyocytes and in endothelial cells, the cellular compartment responsible for this protectio...
Lea M Piermaier,Svenja Caspers,Christina Herold et al.
Lea M Piermaier et al.
In the human organism, all functions are regulated and, therefore, require a feedback mechanism. This control involves a perception of the spatial tensile state of cardiac tissues. The presence and distribution of respective proprioceptive ...
Deficiency of the sphingosine-1-phosphate (S1P) transporter Mfsd2b protects the heart against hypertension-induced cardiac remodeling by suppressing the L-type-Ca2+ channel [0.03%]
鞘氨醇-1-磷酸(Mfsd2b)转运蛋白缺乏通过抑制L型Ca2+通道保护心脏免受高血压诱导的心脏重塑的影响
Dragos Andrei Duse,Nathalie Hannelore Schröder,Tanu Srivastava et al.
Dragos Andrei Duse et al.
The erythrocyte S1P transporter Mfsd2b is also expressed in the heart. We hypothesized that S1P transport by Mfsd2b is involved in cardiac function. Hypertension-induced cardiac remodeling was induced by 4-weeks Angiotensin II (AngII) admin...