The cardio-oncologic burden of breast cancer: molecular mechanisms and importance of preclinical models [0.03%]
乳腺癌的心脏毒性负担：分子机制及前期模型的重要性
J Brauer,M Tumani,N Frey et al.
J Brauer et al.
Breast cancer, the most prevalent cancer affecting women worldwide, poses a significant cardio-oncological burden. Despite advancements in novel therapeutic strategies, anthracyclines, HER2 antagonists, and radiation remain the cornerstones...
Effect of ventricular fibrillation on infarct size after myocardial infarction: a translational study [0.03%]
心肌梗死后室颤对梗死面积影响的转化研究
Neven Stevic,Alexandre Pinède,Nathan Mewton et al.
Neven Stevic et al.
Ventricular fibrillation (VF)-induced cardiac arrest frequently complicates ST-segment elevation myocardial infarction (STEMI). Although larger infarct sizes (IS) correlate with a higher risk of VF, the influence of VF itself on IS has rema...
4E-BP3 deficiency impairs dendritic cell activation and CD4+ T cell differentiation and attenuates α-myosin-specific T cell-mediated myocarditis in mice [0.03%]
4E-BP3缺陷可抑制树突状细胞活化和CD4+T细胞分化并减弱小鼠α-肌球蛋白特异性T细胞介导的心肌炎
Siqi Li,Kazuko Tajiri,Zixun Yuan et al.
Siqi Li et al.
Immune checkpoint inhibitor (ICI)-associated myocarditis is a rare but potentially fatal immune-related adverse event. Previously, we reported a case of ICI-associated myocarditis with elevated autoantibodies to 4E-binding protein 3 (4E-BP3...
Effects of sex and obesity on immune checkpoint inhibition-related cardiac systolic dysfunction in aged mice [0.03%]
衰老小鼠性别和肥胖对免疫检查点抑制剂相关心脏收缩功能障碍的影响
Nabil V Sayour,Dániel Kucsera,Ayham R Alhaddad et al.
Nabil V Sayour et al.
Despite accumulating data on underlying mechanisms, the influence of sex and prevalent cardio-metabolic co-morbidities on the manifestation and severity of immune checkpoint inhibitor (ICI)-induced cardiotoxicity has not been well defined. ...
Single-cell transcriptome unveils unique transcriptomic signatures of human organ-specific endothelial cells [0.03%]
单细胞转录组揭示人器官特异性内皮细胞独特的转录特征
Rui-Ze Niu,Hong-Yan Xu,Hui Tian et al.
Rui-Ze Niu et al.
The heterogeneity of endothelial cells (ECs) across human tissues remains incompletely inventoried. We constructed an atlas of > 210,000 ECs derived from 38 regions across 24 human tissues. Our analysis reveals significant differences in tr...
Investigating the cause of cardiovascular dysfunction in chronic kidney disease: capillary rarefaction and inflammation may contribute to detrimental cardiovascular outcomes [0.03%]
慢性肾脏病心血管功能障碍发病机制研究进展：毛细血管稀疏和炎症导致不良心血管结局？
Siavash Beikoghli Kalkhoran,Maryna Basalay,Zhenhe He et al.
Siavash Beikoghli Kalkhoran et al.
Myocardial ischemia-reperfusion (IR) injury is a major cause of morbidity and mortality in patients with chronic kidney disease (CKD). The most frequently used and representative experimental model is the rat dietary adenine-induced CKD, wh...
CAESAR lives on with IMPACT: bringing rigor and relevance to cardioprotection research [0.03%]
CAESAR与IMPACT齐飞：心脏保护研究的严谨性与相关性共存之路
Roberto Bolli,Xian-Liang Tang
Roberto Bolli
The IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): multicenter pig study on the effect of ischemic preconditioning [0.03%]
改进心脏保护疗法的临床前评估（IMPaCT）：关于缺血预处理作用的多中心猪研究
Petra Kleinbongard,Carlos Galán Arriola,Lina Badimon et al.
Petra Kleinbongard et al.
Numerous cardioprotective interventions have been reported to reduce myocardial infarct size (IS) in pre-clinical studies. However, their translation for the benefit of patients with acute myocardial infarction (AMI) has been largely disapp...
Multicenter Study
Basic research in cardiology. 2024 Dec;119(6):893-909. DOI:10.1007/s00395-024-01083-9 2024
Oxidative stress initiates hemodynamic change in CKD-induced heart disease [0.03%]
氧化应激诱发的慢性肾脏病继发心脏病变血管舒缩功能异常及相关机制研究
Payel Sen,Jules Hamers,Theresa Sittig et al.
Payel Sen et al.
Chronic kidney disease (CKD) predisposes to cardiac remodeling and coronary microvascular dysfunction. Studies in swine identified changes in microvascular structure and function, as well as changes in mitochondrial structure and oxidative ...
N V Bogert,M Therre,S Din et al.
N V Bogert et al.
Cardiac macrophages facilitate electrical conduction through the atrioventricular-node (AV) in mice. A possible role for cardiomyocyte-macrophage coupling on the effect of antiarrhythmic therapy has not been investigated yet. Holter monitor...