Hematopoietic cytokines for cardiac repair: mobilization of bone marrow cells and beyond [0.03%]
造血细胞因子在心脏修复中的应用：动员骨髓细胞及其他作用
Santosh K Sanganalmath,Ahmed Abdel-Latif,Roberto Bolli et al.
Santosh K Sanganalmath et al.
Hematopoietic cytokines, traditionally known to influence cellular proliferation, differentiation, maturation, and lineage commitment in the bone marrow, include granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-s...
The TIR/BB-loop mimetic AS-1 prevents cardiac hypertrophy by inhibiting IL-1R-mediated MyD88-dependent signaling [0.03%]
胸腺素受体/BB-LOOP拟似物AS-1通过抑制IL-1R介导的MyD88依赖性信号防止心脏肥大
Yun Zhu,Ting Li,Juan Song et al.
Yun Zhu et al.
Activation of NF-κB contributes to cardiac hypertrophy and the interleukin-1 receptor (IL-1R)-mediated MyD88-dependent signaling pathway predominately activates NF-κB. Recent studies have shown that the TIR/BB-Loop mimetic (AS-1) disrupte...
Distinct mechanisms for diastolic dysfunction in diabetes mellitus and chronic pressure-overload [0.03%]
糖尿病与慢性压力超负荷导致舒张功能障碍的不同机制
Inês Falcão-Pires,Giuseppina Palladini,Nádia Gonçalves et al.
Inês Falcão-Pires et al.
Chronic pressure-overload and diabetes mellitus are two frequent disorders affecting the heart. We aimed to characterize myocardial structural and functional changes induced by both conditions. Pressure-overload was established in Wistar-ha...
Role of endothelial Nox2 NADPH oxidase in angiotensin II-induced hypertension and vasomotor dysfunction [0.03%]
内皮Nox2型NADPH氧化酶在血管紧张素Ⅱ致高血压和血管功能障碍中的作用
Colin E Murdoch,Sara P Alom-Ruiz,Minshu Wang et al.
Colin E Murdoch et al.
NADPH oxidase (Nox)-derived reactive oxygen species (ROS) are known to be involved in angiotensin II-induced hypertension and endothelial dysfunction. Several Nox isoforms are expressed in the vessel wall, among which Nox2 is especially abu...
Intracoronary administration of cardiac stem cells in mice: a new, improved technique for cell therapy in murine models [0.03%]
一种新的改进的在小鼠模型中进行心脏干细胞冠状动脉给药的技术
Qianhong Li,Yiru Guo,Qinghui Ou et al.
Qianhong Li et al.
A model of intracoronary stem cell delivery that enables transgenesis/gene targeting would be a powerful tool but is still lacking. To address this gap, we compared intracoronary and intramyocardial delivery of lin(-)/c-kit(+)/GFP(+) cardia...
In vitro epithelial-to-mesenchymal transformation in human adult epicardial cells is regulated by TGFβ-signaling and WT1 [0.03%]
TGFβ信号和WT1调控人成人冠状窦细胞向间质转化的体内实验研究
Noortje A M Bax,Angelique A M van Oorschot,Saskia Maas et al.
Noortje A M Bax et al.
Adult epicardial cells are required for endogenous cardiac repair. After myocardial injury, they are reactivated, undergo epithelial-to-mesenchymal transformation (EMT) and migrate into the injured myocardium where they generate various cel...
Antiproliferative effect of estrogen in vascular smooth muscle cells is mediated by Kruppel-like factor-4 and manganese superoxide dismutase [0.03%]
雌激素通过KLF4-MnSOD信号途径抑制血管平滑肌细胞增殖的作用研究
Derya Sivritas,Marc Ulrich Becher,Talin Ebrahimian et al.
Derya Sivritas et al.
The mitochondrial antioxidant enzyme manganese superoxide dismutase (MnSOD) and the zinc finger transcription factor Kruppel-like factor-4 (KLF4) are involved in the regulation of redox homeostasis, apoptosis and cell proliferation. We have...
Oxidative stress-induced formation of a positive-feedback loop for the sustained activation of p38 MAPK leading to the loss of cell division in cardiomyocytes soon after birth [0.03%]
氧化应激通过正反馈环持续激活出生后不久的心肌细胞中p38 MAPK导致心肌细胞丢失分裂能力
Daisuke Matsuyama,Koichi Kawahara
Daisuke Matsuyama
Shortly after birth, mammalian cardiomyocytes irreversibly exit from the cell cycle and become terminally differentiated. The cellular mechanisms responsible for the cessation of cell division and terminal differentiation of cardiomyocytes ...
Acute vasomotor paralysis and potential downstream effects of paclitaxel from stents implanted for saphenous vein aorto-coronary bypass stenosis [0.03%]
药物洗脱支架治疗大隐静脉冠脉旁路移植术吻合口狭窄导致的急性血管调节麻痹及潜在继发效应：紫杉醇的作用
Petra Kleinbongard,Dirk Böse,Thomas Konorza et al.
Petra Kleinbongard et al.
Implantation of bare metal stents (BMS) induces the release not only of particulate debris, but also of soluble vasoconstrictors which contribute to microvascular impairment. So this study aimed at addressing the potential attenuation of su...
Cardioprotection via adaptation to hypoxia: expanding the timeline and targets? [0.03%]
缺氧预适应诱导心肌保护的时效性和靶点？
Karin Przyklenk,Peter Whittaker
Karin Przyklenk