CD163+ macrophages attenuate pressure overload-induced left ventricular systolic dysfunction and cardiac mitochondrial dysfunction via interleukin-10 [0.03%]
CD163+巨噬细胞通过白细胞介素-10缓解压力超负荷引起的左心室收缩功能障碍和心脏线粒体功能障碍
Wei Ni,Xiaofeng Ge,Yang Liu et al.
Wei Ni et al.
Macrophage depletion exacerbates pressure overload-induced heart failure, but therapeutic translation is hindered by macrophage subset heterogeneity. The functional role of CD163+ macrophages in heart failure remains unclear. Transverse aor...
Reinstating respiratory heart rate variability improves hemodynamic responses during exercise in heart failure with reduced ejection fraction [0.03%]
恢复呼吸心率变异可改善射血分数降低型心力衰竭患者的运动血液动力学反应
Julia Shanks,Mridula Pachen,Nigel A Lever et al.
Julia Shanks et al.
Individuals with heart failure have significantly reduced exercise capacity, a critical life-limiting symptom for those living with the disease. Heart failure is negatively correlated with decreased heart rate variability, including the los...
A new model of heart failure with preserved ejection fraction induced by metabolic syndrome in Ossabaw miniature swine [0.03%]
代谢综合征诱导的心力衰竭射血分数保留的新模型——奥萨巴微猪研究
Xian-Liang Tang,Mouhamad Alloosh,Qinghui Ou et al.
Xian-Liang Tang et al.
A major obstacle to progress in heart failure with preserved ejection fraction (HFpEF) is the paucity of clinically relevant animal models. We developed a large, translationally relevant model in Ossabaw minipigs, which are genetically pred...
Tyrosine phosphorylation of Kir6.2 subunit negatively regulates cardiac KATP channel activity [0.03%]
Kir6.2亚单位酪氨酸磷酸化对心肌KATP通道活性的负性调节作用
Yating Zhi,Bin Yang,Jianyi Huo et al.
Yating Zhi et al.
The plasma membrane ATP-sensitive potassium (KATP) channel in cardiac myocytes plays a critical role in protecting the heart against ischemic injury. Post-translational modifications regulate KATP channel activity and play a role in cardiop...
Impact of chronic hyperglycaemia on the coronary microcirculation - benefits of targeting IL-36 and diet reversal [0.03%]
慢性高血糖对冠状微循环的影响及靶向白细胞介素-36和饮食逆转的益处
Juma El-Awaisi,Dean Kavanagh,Silke Heising et al.
Juma El-Awaisi et al.
Following myocardial infarction (MI), patients with type 2 diabetes mellitus (T2DM) have poorer prognosis which may be linked to increased susceptibility of coronary microvessels to injury. Interleukin-36 (IL-36) may mediate this injury but...
Triiodothyronine protects infarcted myocardium by reducing apoptosis and preserving mitochondria [0.03%]
三碘甲状腺原氨酸通过减少凋亡和保持线粒体功能保护心肌梗死区细胞
Domenico Cerullo,Polyxeni Mantzouratou,Angelo M Lavecchia et al.
Domenico Cerullo et al.
Myocardial infarction (MI) is a leading cause of heart failure, with thyroid hormone (TH) signaling playing a key role in heart function and postinfarct recovery. Despite evidence of TH administration's safety in cardiac patients, inconsist...
The ketone body 3-hydroxybutyrate increases cardiac output and cardiac contractility in a porcine model of cardiogenic shock: a randomized, blinded, crossover trial [0.03%]
一项随机、盲法、交叉试验：β-羟基丁酸酮体可增加心脏骤停猪模型中的心输出量和心肌收缩力
Oskar Kjærgaard Hørsdal,Alexander Møller Larsen,Kasper Lykke Wethelund et al.
Oskar Kjærgaard Hørsdal et al.
Cardiogenic shock (CS) is characterized by reduced cardiac output (CO), reduced end-organ perfusion, and high mortality. Medical therapies have failed to improve survival. The ketone body 3-hydroxybutyrate (3-OHB) enhances cardiac function ...
Critical analysis of descriptive microRNA data in the translational research on cardioprotection and cardiac repair: lost in the complexity of bioinformatics [0.03%]
心肌保护和心脏修复转化研究中微小RNAs描述性数据的批判分析：生物信息学复杂性带来的困惑
Mariann Gyöngyösi,Julia Guthrie,Ena Hasimbegovic et al.
Mariann Gyöngyösi et al.
The unsuccessful translation of cardiac regeneration and cardioprotection from animal experiments to clinical applications in humans has raised the question of whether microRNA bioinformatics can narrow the gap between animal and human rese...
Exendin-4 improves cerebral ischemia by relaxing microvessels, rapidly increasing cerebral blood flow after reperfusion [0.03%]
艾塞那肽通过放松微血管，在再灌注后迅速增加脑血流，从而改善脑缺血
Yujie Chen,Lei Wang,Yutong Zhou et al.
Yujie Chen et al.
Intravenous thrombolysis remains the cornerstone for restoring cerebral reperfusion post-stroke. Despite recombinant tissue plasminogen activator (rtPA) achieving arterial reperfusion within 6 h, persistent microcirculatory blood flow reduc...
Necrosis-like cell death modes in heart failure: the influence of aetiology and the effects of RIP3 inhibition [0.03%]
心力衰竭中的类坏死细胞死亡方式：病因影响和RIP3抑制的影响
Izabela Jarabicová,Csaba Horváth,Jaroslav Hrdlička et al.
Izabela Jarabicová et al.
Since cell dying in heart failure (HF) may vary based on the aetiology, we examined the main forms of regulated necrosis, such as necroptosis and pyroptosis, in the hearts damaged due to myocardial infarction (MI) or pressure overload. We a...