Exendin-4 improves cerebral ischemia by relaxing microvessels, rapidly increasing cerebral blood flow after reperfusion [0.03%]
艾塞那肽通过放松微血管，在再灌注后迅速增加脑血流，从而改善脑缺血
Yujie Chen,Lei Wang,Yutong Zhou et al.
Yujie Chen et al.
Intravenous thrombolysis remains the cornerstone for restoring cerebral reperfusion post-stroke. Despite recombinant tissue plasminogen activator (rtPA) achieving arterial reperfusion within 6 h, persistent microcirculatory blood flow reduc...
Necrosis-like cell death modes in heart failure: the influence of aetiology and the effects of RIP3 inhibition [0.03%]
心力衰竭中的类坏死细胞死亡方式：病因影响和RIP3抑制的影响
Izabela Jarabicová,Csaba Horváth,Jaroslav Hrdlička et al.
Izabela Jarabicová et al.
Since cell dying in heart failure (HF) may vary based on the aetiology, we examined the main forms of regulated necrosis, such as necroptosis and pyroptosis, in the hearts damaged due to myocardial infarction (MI) or pressure overload. We a...
IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): a small animal acute myocardial infarction randomized-controlled multicenter study on the effect of ischemic preconditioning [0.03%]
改善心脏保护疗法的临床前评估（IMPACT）：缺血预处理对小动物急性心肌梗死随机对照多中心研究
Sauri Hernandez-Resendiz,Reinis Vilskersts,David Aluja et al.
Sauri Hernandez-Resendiz et al.
Although many cardioprotective interventions have been shown to limit infarct size (IS), in preclinical animal studies of acute myocardial ischemia/reperfusion injury (IRI), their clinical translation to patient benefit has been largely dis...
Assessing customized multivalent chemokine-binding peptide treatment in a murine model of coxsackievirus B3 myocarditis [0.03%]
在柯萨奇病毒B3心肌炎的小鼠模型中评估定制的多价趋化因子结合肽治疗方案
Nicolas Kelm,Meike Kespohl,Gintare Smagurauskaite et al.
Nicolas Kelm et al.
Myocarditis, an inflammatory disease of the heart muscle, is often triggered by viral infections. This inflammation, which can lead to severe cardiac dysfunction and adverse outcomes, is mediated by various CC and CXC chemokines that intera...
Associations between female sex hormones, estrous cycle, ischemic preconditioning and myocardial infarct size after ischemia-reperfusion injury [0.03%]
雌性性激素，发情周期，缺血预处理和缺血再灌注损伤后心肌梗死面积的关系研究
Tetiana Pylova,Ahmed Elmahdy,Maryna Krasnikova et al.
Tetiana Pylova et al.
Studies on sex differences in myocardial infarction (MI) typically focus on males versus females, the exploration of hormonal physiologic variations and their impact on the infarct size remains limited. The objective of this study was to ex...
Evolocumab attenuates myocardial ischemia/reperfusion injury by blocking PCSK9/LIAS-mediated cuproptosis of cardiomyocytes [0.03%]
依洛尤单抗通过抑制PCSK9/LIAS介导的心肌细胞铜死亡减轻心肌缺血再灌注损伤
Zi-Zhuo Li,Lei Guo,Yan-Liang An et al.
Zi-Zhuo Li et al.
Myocardial ischemia‒reperfusion (I/R) injury is the crucial cause of poor prognosis after revascularization in patients with myocardial infarction (MI) due to the lack of specific therapeutic drugs. Proprotein convertase subtilisin/Kexin t...
Intravenous and oral administration of the synthetic RNA drug, TY1, reverses heart failure with preserved ejection fraction in mice [0.03%]
静脉和口服合成RNA药物TY1可逆转小鼠射血分数保留的心力衰竭
Kazutaka Miyamoto,Xaviar M Jones,Shukuro Yamaguchi et al.
Kazutaka Miyamoto et al.
TY1, a synthetic non-coding RNA (ncRNA) bioinspired by small Y RNAs abundant in extracellular vesicles (EVs), decreases cGAS/STING activation in myocardial infarction and thereby attenuates inflammation. Motivated by the concept that heart ...
High-resolution DNA methylation changes reveal biomarkers of heart failure with preserved ejection fraction versus reduced ejection fraction [0.03%]
高分辨率DNA甲基化变化揭示了射血分数保留型心力衰竭与射血分数降低型心力衰竭的生物标志物的区别
Giuditta Benincasa,Mark E Pepin,Vincenzo Russo et al.
Giuditta Benincasa et al.
Novel biomarkers are needed to better identify-and distinguish-heart failure with preserved ejection fraction (HFpEF) from other clinical phenotypes. The goal of our study was to identify epigenetic-sensitive biomarkers useful to a more acc...
Inter-organ communication: pathways and targets to cardioprotection and neuro-protection. A report from the 12th Hatter Cardiovascular Institute workshop [0.03%]
器官间通讯：心脏保护和神经保护的途径与靶点。第十二届Hatter心血管研究所研讨会报告
L Pearce,C Galán-Arriola,R M Bell et al.
L Pearce et al.
A long-standing aim in the setting of various pathologies including acute myocardial infarction, chronic kidney disease (CKD), and ischaemic stroke, has been to identify successful approaches to augment cellular and organ protection. Althou...
Anna-Sophia Leven,Natalie Wagner,Stephan Nienaber et al.
Anna-Sophia Leven et al.
Cardiovascular disease and cancer are the leading causes of death in the Western world. The associated risk factors are increased by smoking, hypertension, diabetes, sedentary lifestyle, aging, unbalanced diet, and alcohol consumption. Ther...