Fast skeletal myosin binding protein-C expression exacerbates dysfunction in heart failure [0.03%]
快肌球蛋白结合蛋白C的表达加重心力衰竭时的心肌功能障碍
James W McNamara,Taejeong Song,Perwez Alam et al.
James W McNamara et al.
During heart failure (HF), gene and protein expression profiles undergo extensive compensatory and pathological remodeling. We previously observed that fast skeletal myosin binding protein-C (fMyBP-C) is upregulated in diseased mouse hearts...
P38α deficiency alleviates myocardial ischemia/reperfusion injury by stabilizing c‑Myc to inhibit ferroptosis [0.03%]
P38α缺失通过稳定c-Myc来抑制铁死亡从而缓解心肌缺血再灌注损伤
Xiaohu Ouyang,Shuxin Song,Yalan Dong et al.
Xiaohu Ouyang et al.
Myocardial ischemia/reperfusion (I/R) injury constitutes a major clinical challenge in ischemic heart disease, and ferroptosis has been recognized as a core driver of cardiomyocyte death during reperfusion. However, the upstream regulatory ...
MiR-145-5p modulates collagen production and fibroblast behaviour after cardiac injury partially via COL5A1 [0.03%]
MiR-145-5p通过COL5A1部分调节心脏损伤后的胶原生成及成纤维细胞行为
Hong Wang,Jere Paavola,Sanni Perttunen et al.
Hong Wang et al.
In contrast to humans, zebrafish hearts after cryoinjury undergo transient fibrotic scarring that subsequently resolves and renews with functional cardiomyocytes. To understand the molecular mechanisms underlying cardiac scarring and fibrot...
Meteorin-like regulates cardiac repair via macrophage modulation following myocardial infarction [0.03%]
Meteorin样蛋白通过调节心肌梗死后的巨噬细胞活化来参与心脏修复
G Ferrer-Curriu,A Blasco-Roset,A Navarro-Gascon et al.
G Ferrer-Curriu et al.
After myocardial infarction (MI), the heart undergoes a reparative process that includes an initial acute inflammatory phase followed by a subsequent reparative phase. The transition between these phases is crucial for cardiac recovery, but...
Mesenteric denervation ameliorates post‑infarction heart failure alongside alterations in the gut-nerve-microbiota axis [0.03%]
肠去神经支配通过改变肠道-神经-微生物群轴来缓解心梗后的心力衰竭
Zhongqiang Xu,Shengchan Wang,Guirui Sang et al.
Zhongqiang Xu et al.
Sympathetic overactivity and gut microbiota dysbiosis drive chronic heart failure (CHF) progression. This study explored the associations of mesenteric denervation (MDN) with cardioprotection and potential involvement of the nerve-microbiot...
Historical account of reperfusion therapy and the development of cardioprotection beyond reperfusion [0.03%]
心肌再灌注治疗的历史及再灌注之外的心肌保护的发展变迁
Gerd Heusch,Petra Kleinbongard,Bernard J Gersh
Gerd Heusch
The only way to salvage myocardium from infarction is timely reperfusion of the occluded coronary artery. Timely reperfusion reduces infarct size and mortality. The history of reperfusion therapy from the first clinical use of intravenous s...
Cardiomyocyte-specific depletion of integrin α3 preserves cardiac function after myocardial infarction [0.03%]
心脏成纤维细胞特异性整合素α3缺失可改善心肌梗死后的心脏功能
Nicolai V Bogert,Anita A Kuhnle,Shabana Din et al.
Nicolai V Bogert et al.
Integrins, a family of transmembrane receptors that mediate cell-extracellular (ECM) interactions, play a pivotal role in the heart to maintain cardiac function and tissue integrity. As they sense extracellular signals, their expression cha...
Xinjie Xu,Yukun Luo,Tao Lei et al.
Xinjie Xu et al.
Myocardial reverse remodeling (RR) represents the structural, functional, cellular, and molecular recovery of the failing heart, leading to long-term prognostic improvements. This process can be mediated by various clinical modalities, incl...
Jasper Iske,Henriette Thau,Joshua M Mesfin et al.
Jasper Iske et al.
Compared to classic myocardial infarction (cMI), myocardial infarction with non-obstructive coronary arteries (MINOCA) is characterized by symptoms consistent with acute coronary syndrome, but without demonstrable coronary obstruction. Ther...
Protection against postoperative atrial fibrillation via antiplatelet aggregation induced by remote ischemic preconditioning during off-pump coronary artery bypass grafting [0.03%]
远程缺血预处理诱导抗血小板聚集预防冠状动脉旁路移植术房颤并发症
Qin Jiang,Yi Zheng,Keli Huang et al.
Qin Jiang et al.
Off-pump coronary artery bypass grafting (OPCABG) is associated with increased platelet aggregation and a higher incidence of postoperative atrial fibrillation (POAF). Remote ischemic preconditioning (RIPC) has been reported as a promising ...