Lejla Paracka,Dirk Dressler
Lejla Paracka
Chronic migraine (CM) is a common primary headache occurring on 15 or more days per month and for more than three months. It presents a considerable therapeutic challenge. Botulinum toxin (BoNT) has emerged as a promising treatment for CM, ...
Serum L-ornithine-derived polyamines as indicators of Parkinson disease progression [0.03%]
血清L-鸟氨酸衍生的聚胺作为帕金森病进展指标
Peter A LeWitt,Jia Li,Peggy Auinger;Parkinson Study Group DATATOP Investigators
Peter A LeWitt
Prior studies reported that biospecimen concentrations of L-ornithine-derived polyamines (ODPAs) and their metabolites differentiated Parkinson disease (PD) from healthy controls. We investigated ODPA metabolism in CSF and serum specimens f...
Safety of COMT-inhibitors in parkinson's disease: a phase-IV comparative study on adverse events of Tolcapone, Entacapone and Opicapone [0.03%]
针对帕金森病的COMT抑制剂安全性： Tolcapone、恩他卡朋和奥匹卡朋不良事件的四期比较研究
Pasquale Maria Pecoraro,Simona Paola Carbone,Francesco Bugamelli et al.
Pasquale Maria Pecoraro et al.
Catechol-O-methyltransferase (COMT) inhibitors-Tolcapone, Entacapone, and Opicapone-are adjunct therapies for advanced Parkinson's disease (PD), improving motor control. Their distinct safety profiles may influence clinical decisions and pa...
Posttraumatic growth and wellbeing in three countries after COVID-19: analysis using a random intercept cross-lagged panel model [0.03%]
新冠肺炎疫情后三个国家的创伤成长与幸福感研究：随机截距交叉滞后模型分析
Michio Murakami,Tomoyuki Kobayashi,Asako Miura
Michio Murakami
The long-term relationship between posttraumatic growth (PTG) and wellbeing after the COVID-19 pandemic remains unclear. This study aimed to examine their levels and changes at the individual level over time as well as to explore the bidire...
The prevalence of gastrointestinal dysfunction and its impact on quality of life in Parkinson's disease [0.03%]
帕金森病患者胃肠功能障碍的流行率及其对生活质量的影响
Cheshta Arora,Nitish Kamble,Vikram V Holla et al.
Cheshta Arora et al.
Gastrointestinal (GI) dysfunction is one of the most common and earliest non-motor symptoms (NMS) in Parkinson's disease (PD). We aimed to study the prevalence and severity of GI dysfunction and its impact on quality of life (QoL) in patien...
Household herbicide use is associated with the risk of Parkinson's disease and a younger age at onset in PPMI and Fox Insight cohorts [0.03%]
家用除草剂的使用与PPMI和Fox Insight队列帕金森病的风险及发病年龄的相关性研究
Bruno Lopes Santos-Lobato,Artur F S Schuh,Ignacio F Mata
Bruno Lopes Santos-Lobato
The association of household pesticide exposure with Parkinson's disease has been less explored than occupational exposure. Using data from the Parkinson's Progression Markers Initiative and the Fox Insight study, we analyzed the associatio...
Parkinson's disease, aerobic exercise and photobiomodulation: a randomised controlled trial [0.03%]
帕金森病的有氧锻炼和光生物调节法：随机对照试验
Luis Santos,Johannes Burtscher,Luis de Taboada
Luis Santos
Although Parkinson's disease (PD) is the neurological disease with the fastest growing prevalence, no disease-modifying treatments are yet available. However, regular exercise and photobiomodulation (PBM) with near-infrared light represent ...
Correction: Insulin resistance: fueling oxidative stress and neurodegeneration [0.03%]
纠正：胰岛素抵抗：促进氧化应激和神经退行性病变
Laia Berridi-Chamorro,Barbara Zulli,Eugenio Barone
Laia Berridi-Chamorro
Linking diet, gut microbiota, and metabolites to Parkinson's disease risk: a shotgun metagenomic comparison of Japanese and Taiwanese cohorts [0.03%]
饮食、肠道微生物组和代谢物与帕金森病风险的关系：日本队列和台湾队列鸟枪法元基因组的比较
Masaaki Hirayama,Tetsuya Maeda,Kenichi Kashihara et al.
Masaaki Hirayama et al.
Emerging evidence suggests that gut microbiota and its metabolites play pivotal roles in the pathogenesis of Parkinson's disease (PD). However, cross-national differences in diet and microbial composition may account for the striking variab...
Automatic neural mechanisms of social synchrony: pupil and Blink responses in adults with ADHD symptoms [0.03%]
自闭症谱系障碍成人患者社会同步的自动神经机制：瞳孔和眨眼反应
Or Lipschits,Sapir Sadon,Ronny Geva
Or Lipschits
Human social interactions involve both conscious behaviors, such as speech and gestures, and automatic responses regulated by dopaminergic and noradrenergic neural networks, including pupil dilation and blinking. Dysfunctions in dopamine an...