Symptom prevalence and pharmacological management of late-stage Parkinson's disease (LSPD): a cross-sectional, multinational survey [0.03%]
晚期帕金森病(PDP)的症状发生率及其药理学治疗:一项跨国横断面调查研究
Christine Pallauf,Christiane Weck,Clemens Brandl et al.
Christine Pallauf et al.
Late-stage Parkinson's disease (LSPD) presents with disabling motor and non-motor symptoms, the latter becoming dominant in the late stage. There is limited information on LSPD. This study aimed to identify common symptoms and common drug t...
Dysphagia and gastrointestinal disorders in Parkinson's disease: towards a diagnostic standard operating procedure for the interprofessional neurological outpatient care team [0.03%]
帕金森病的吞咽困难和胃肠道疾病：多学科神经科门诊团队诊断标准操作程序的研究进展
Inga Claus,Carsten Buhmann,Alessandra Fanciulli et al.
Inga Claus et al.
Gastrointestinal Disorders in people with Parkinson's disease (PwP) are able to cause widespread clinical symptoms which can be challenging to classify in day-to-day clinical practice. In the upper gastrointestinal tract (GIT) oropharyngeal...
123I-FP-CIT uptake and behavioral disinhibition in the frontotemporal dementia spectrum: an exploratory DAT-SPECT study [0.03%]
多巴胺转运体单光子发射计算机断层扫描显像探针123I-FP-CIT摄取与额颞叶变性谱系的冲动控制障碍：一项探索性研究
Shigeki Katakami,Yuto Satake,Daiki Taomoto et al.
Shigeki Katakami et al.
Behavioral disinhibition is a core feature of behavioral variant frontotemporal dementia (bvFTD) and occurs across related FTD-spectrum presentations. Serotonergic dysfunction may contribute to behavioral dysregulation; therefore, we primar...
Polygenic risk meets early trauma: toward a neuropsychodevelopmental model of schizophrenia [0.03%]
多基因风险与早期创伤相遇：迈向精神分裂症的神经心理发展模式
Antonio Del Casale,Paolo Girardi,Jan Francesco Arena et al.
Antonio Del Casale et al.
Advances in psychiatric genetics have substantially reshaped current models of schizophrenia-spectrum disorders, shifting the focus from single risk factors to polygenic liability and its interaction with environmental adversity. Polygenic ...
Impact of serotonin transporter deficiency on parvalbumin- and neuropeptide Y-producing neurons of the lateral and basolateral amygdalar nuclei [0.03%]
五羟色胺转运蛋白缺乏对侧杏仁核和基底外侧杏仁复合体中寄主(parvalbumin)和神经肽Y产生的神经元的影响
Henning Schwert,Elif Salur,Mirjam Richard et al.
Henning Schwert et al.
Hyperexcitability of lateral (La) and basolateral (BL) amygdalar nuclei (BLA) is a hallmark of anxiety-related disorders in humans. Excitation of BLA projection neurons (PN) is fine-tuned by inhibitory interneurons (INs), and monoaminergic ...
X-linked dystonia parkinsonism as a cause of isolated lingual dystonia (ILD) [0.03%]
X染色体隐性遗传性 dystonia parkinsonism 是舌肌孤立性 dystonia (ILD) 的病因之一
Lowrence Precious Dichoso,Daryl Dakay,Ana Westenberger et al.
Lowrence Precious Dichoso et al.
Dystonia is a movement disorder characterized by sustained or intermittent muscle contractions that cause abnormal postures or repetitive movements. Isolated lingual dystonia (ILD) is a rare form of oromandibular dystonia, which affects onl...
J Douglas Bremner
J Douglas Bremner
Posttraumatic stress disorder (PTSD) is associated with symptoms of intrusive memories, avoidance, and hyperarousal. Accumulated evidence shows that these symptoms are related to changes in brain areas involved in memory and emotion. The pu...
Therapeutic drug monitoring in children and adolescents treated with quetiapine for different psychiatric disorders: results of the TDM-VIGIL pharmacovigilance study [0.03%]
喹硫平治疗不同精神障碍的儿童和青少年的治疗药物监测：TDM-VIGIL药物警戒研究结果
Alina Kaiser,Karin Maria Egberts,Hans-Willi Clement et al.
Alina Kaiser et al.
Although quetiapine is increasingly used off-label in children and adolescents with various psychiatric disorders, there is little evidence on the relationship between quetiapine dose and serum concentration, and therapeutic reference range...
Serotonin deficiency caused by inactivation of Tph2 in mice leads to widespread sex-dependent changes in cerebral oxidative metabolic activity [0.03%]
小鼠脑特异酶法Ⅱ失活导致血清素缺乏及其广泛的性二向分歧的脑氧化代谢活动变化
Pilleriin Kupper,Margus Kanarik,Marianna Norden et al.
Pilleriin Kupper et al.
Tryptophan hydroxylase 2 (TPH2), the rate-limiting enzyme of serotonin synthesis in the CNS, has been associated with numerous behavioural traits and psychiatric disorders. Tph2 modified mice present altered sensitivity to stress, and exces...
Cerebellar ataxia in the Philippines: a scoping review of reported cases and practical approach [0.03%]
菲律宾小脑共济失调的文献综述及实用方法概述
Alfand Marl F Dy Closas,Jeryl Ritzi T Yu,Gerard Saranza et al.
Alfand Marl F Dy Closas et al.
Cerebellar ataxia is characterized by incoordination and decomposition of movements, manifesting as gait instability, limb incoordination, oculomotor dysfunction, and scanning dysarthria. Ataxias may be acquired or genetic. Currently, there...