Unrevealing the sequence of dysphagia progression in ALS: an event-based, FEES-driven staging approach [0.03%]
ALS吞咽障碍进程的阶段性及其食管内反流表现：事件驱动型检查方法
Giammarco Milella,Maria Luisa Fiorella,Vittorio Velucci et al.
Giammarco Milella et al.
Dysphagia drives morbidity and mortality in amyotrophic lateral sclerosis (ALS), yet staging systems treat it as a binary milestone and do not capture its trajectory. Reports diverge on the earliest abnormality, with some citing cohesive-bo...
A transdiagnostic structural brain signature of Parkinsonian and Essential Tremor [0.03%]
帕金森病和原发性震颤的跨诊断脑结构特征
Christian Ineichen,Fraser Callaghan,Heide Baumann-Vogel et al.
Christian Ineichen et al.
Parkinson's disease (PD) and Essential Tremor (ET) are heterogeneous, yet distinct disorders. At the same time, PD and ET show overlapping features such as tremor-predominant phenotypes. These heterogeneities and overlaps pose challenges fo...
Resting-state EEG changes associated with cognitive decline in Parkinson's disease: a systematic review [0.03%]
帕金森病认知障碍相关的静息态EEG改变的系统综述研究
Milena Spoa,Sara Monti,Jovana Bjekić et al.
Milena Spoa et al.
Cognitive decline is a common and disabling feature of Parkinson's disease (PD), frequently progressing from mild cognitive impairment to Parkinson's disease dementia. Due to substantial heterogeneity in PD phenotypes, current research is i...
Impact of device-aided therapies on quality of life in patients with Parkinson's disease. A comparative multicenter observational study [0.03%]
辅助装置对帕金森病患者生存质量的影响。多中心观察研究比较
Diego Santos-García,Ángela Solleiro,Guillermo González-Ortega et al.
Diego Santos-García et al.
Device aided-therapies (DATs) improve health-related quality of life (HRQoL) in people with Parkinson's disease (PwP). However, no studies comparing all DATs have been conducted to date. Our aim was to compare the effect of different DATs o...
Gabriel Blanco-Gomez,Nicky Wright,Christian O&#x;Reilly et al.
Gabriel Blanco-Gomez et al.
Autism spectrum disorder (ASD), like many other neurodevelopmental conditions, arises from complex interactions between genetics and environmental factors. In the last 50 years, significant efforts have been made to identify biomarkers and ...
Pesticides and parkinson's disease: causal relationship at the population and individual level? [0.03%]
杀虫剂与帕金森病：人群和个体层面上的因果关系？
Matthias Höllerhage
Matthias Höllerhage
Pesticide exposure has been associated with an increased risk of Parkinson's disease (PD). As a result, PD has been recognized as an occupational disease among agricultural workers in France for over a decade. In March 2024, a similar recom...
Björn Falkenburger,Alessandra Fanciulli,Monika Pötter-Nerger et al.
Björn Falkenburger et al.
Digital health technologies (DHTs) are on the verge of changing treatment of Parkinson's disease (PD). This narrative overview article describes DHTs that are already used or in development, focusing on technologies available in Germany and...
Patrick Süß,Martin Regensburger,Heiko Gassner et al.
Patrick Süß et al.
Lifestyle medicine is an evolving concept integrating preventive and therapeutic approaches related to physical activity, nutrition, sleep, stress management, social interaction, and cessation of substance abuse aiming to optimize health ou...
Jaime Kulisevsky,Pedro García-Ruíz,Tiago Fleming Outeiro et al.
Jaime Kulisevsky et al.
Parkinson's disease (PD) is a progressive neurodegenerative disorder with a wide variety of symptoms and evolution. In addition, the response to antiparkinsonian medication is not predictable, especially for those patients with advanced PD....
Elucidating the crystal structure of botulinum neurotoxin type A: a personal remembrance [0.03%]
破译肉毒杆菌毒素A型晶体结构的一点个人回忆
D Borden Lacy
D Borden Lacy
Botulinum neurotoxins (BoNTs) are the bacterial proteins responsible for the flaccid paralysis and lethal effects of botulism. They act by inhibiting neurotransmitter release, primarily at peripheral cholinergic nerve terminals, and have tr...