Assessment of the evolutionary origin and possibility of CRISPR-Cas (CASS) mediated RNA interference pathway in Vibrio cholerae O395 [0.03%]
评估霍乱弧菌O395中CRISPR-Cas（CASS）介导的RNA干扰途径的进化起源及可能性
Sajib Chakraborty,T M Zaved Waise,Faizule Hassan et al.
Sajib Chakraborty et al.
Bacteria have developed several defense mechanisms against bacteriophages over evolutionary time, but the concept of prokaryotic RNA interference mediated defense mechanism against phages and other invading genetic elements has emerged only...
Development of a database and ontology for pathogenic pathways in periodontitis [0.03%]
牙周炎病原途径的数据库和本体论的发展
Asami Suzuki,Takako Takai-Igarashi,Yukihiro Numabe et al.
Asami Suzuki et al.
It is getting familiar that pathway information greatly contributes to elucidate the molecular basis of human disease with large-scale biological data. We developed a pathway database for molecular pathology in periodontitis named 'Pathogen...
In silico identification of candidate drug and vaccine targets from various pathways in Neisseria gonorrhoeae [0.03%]
从淋球菌各种途径中进行候选药物和疫苗靶点的计算机识别
Debmalya Barh,Anil Kumar
Debmalya Barh
Neisseria gonorrhoeae is responsible for causing gonorrhea, one of the most common sexually transmitted diseases prevailing globally. Although extensive researches are in progress in order to control the transmission of the disease and to d...
Systematic analysis of disease-related regulatory mutation classes reveals distinct effects on transcription factor binding [0.03%]
疾病相关调控突变类型的整体分析揭示了对转录因子结合的不同的影响
Kirsti Laurila,Harri Lähdesmäki
Kirsti Laurila
Detailed knowledge of the mechanisms of transcriptional regulation is essential in understanding the gene expression in its entirety. Transcription is regulated, among other things, by transcription factors that bind to DNA and can enhance ...
Evolutionary origin of the tumor suppressor hyperplastic discs protein [0.03%]
肿瘤抑制因子hyperplastic discs蛋白的进化起源
Leonid V Omelyanchuk,Julya A Pertseva,John M Saul
Leonid V Omelyanchuk
Previous evolutionary study of the tumor suppressor Merlin revealed that this protein family was produced by very early metazoans with the exception of some or all flatworm lineages [Golovnina et al., 2005]. We ask whether other tumor-suppr...
PlasmoID: A P. falciparum protein information discovery tool [0.03%]
PlasmoID：一项关于P. falciparum蛋白质信息的发现工具
Aditya Rao,Sri Jyothsna Yeleswarapu,Gudladona Raghavendra et al.
Aditya Rao et al.
Plasmodium falciparum is the parasite responsible for more than 90% of deaths that occur due to malaria. Organization and mining of 'omic' (genomic, proteomic, transcriptomic, interactomic) data can improve our understanding of P. falciparu...
Amino-acid residue association models for large scale protein-protein interaction prediction [0.03%]
基于氨基酸残基关联模型的大规模蛋白质相互作用预测方法
Raghuraj Rao,Kyaw Tun,Samavedham Lakshminarayanan et al.
Raghuraj Rao et al.
The computational prediction of protein-protein interactions (PPI) is an essential complement to direct experimental evidence. Traditional approaches rely on less available or computationally predicted surface properties, show database-spec...
An emergent self-organizing map based analysis pipeline for comparative metabolome studies [0.03%]
基于自组织映射的比较代谢组学研究分析流程
Isam Haddad,Karsten Hiller,Eliane Frimmersdorf et al.
Isam Haddad et al.
Modern high-throughput techniques allow for the identification and quantification of hundreds of metabolites ofa biological system which cover central parts of the metabolome. Due to the amount and complexity of obtained data there is an in...
Evolutionary analysis for the functional divergence of the Spo0A protein: the key sporulation control element [0.03%]
芽孢生成调控重要元件Spo0A蛋白的功能分化进化分析
Andrés Julián Gutiérrez Escobar,Dolly Montoya Castaño
Andrés Julián Gutiérrez Escobar
Sporulation involves inducing scores of genes in a temporally and spatially coordinated cell development programme. Its initiation is controlled by an expanded two-component signal transduction system, termed a phosphorelay. The Spo0A respo...