Regulatory Effects of Cooperativity and Signal Profile on Adaptive Dynamics in Incoherent Feedforward Loop Networks [0.03%]
不一致前馈环路网络中合作性和信号特征对适应动力学的调节作用
Necmettin Yildirim,Thomas Brew,Ahmet Ay
Necmettin Yildirim
Cellular adaptation to external signals is essential for biological functions, and it is an important field of interest in systems biology. This study examines the impact of cooperativity on the adaptation response of the Incoherent Feedfor...
scAN1.0: A reproducible and standardized pipeline for processing 10X single cell RNAseq data [0.03%]
scAN1.0：处理10X单细胞RNA-seq数据的可重复且标准化的流水线
Maxime Lepetit,Mirela Diana Ilie,Marie Chanal et al.
Maxime Lepetit et al.
Single cell transcriptomics has recently seen a surge in popularity, leading to the need for data analysis pipelines that are reproducible, modular, and interoperable across different systems and institutions.To meet this demand, we introdu...
Jonathan B L Bard
Jonathan B L Bard
Darwin's and Wallace's 1859 explanation that novel speciation resulted from natural variants that had been subjected to selection was refined over the next 150 years as genetic inheritance and the importance of mutation-induced change were ...
Where Do CABs Exist? Verification of a specific region containing concave Actin Bundles (CABs) in a 3-Dimensional confocal image [0.03%]
CABs存在于何处？在共聚焦图像的三维空间中验证包含凹形肌动蛋白束（CAB）的特定区域存在性
Doyoung Park
Doyoung Park
CABs (Concave Actin Bundles) are oriented against the scaffold transversally in a manner different from traditional longitudinal F-actin bundles. CABs are present in a specific area, and do not exist in random areas. Biologically, CABs are ...
Network analysis of host-pathogen protein interactions in microbe induced cardiovascular diseases [0.03%]
微生物诱发心血管疾病中的宿主病原蛋白相互作用网络分析
Nirupma Singh,Sneha Rai,Rakesh Bhatnagar et al.
Nirupma Singh et al.
Large-scale visualization and analysis of HPIs involved in microbial CVDs can provide crucial insights into the mechanisms of pathogenicity. The comparison of CVD associated HPIs with the entire set of HPIs can identify the pathways specifi...
Multiscale modeling of tumor response to vascular endothelial growth factor (VEGF) inhibitor [0.03%]
血管内皮生长因子(VEGF)抑制剂的肿瘤反应的多尺度模型
Melisa Hendrata,Janti Sudiono
Melisa Hendrata
Vascular endothelial growth factor (VEGF) has been known as a key mediator of angiogenesis in cancer. Bevacizumab is anti-VEGF monoclonal antibody that has been approved by the FDA as a first-line treatment in many types of cancer. In this ...
Lattice-based Monte Carlo simulation of the effects of nutrient concentration and magnetic field exposure on yeast colony growth and morphology [0.03%]
基于晶格的蒙特卡罗模拟营养浓度和磁场暴露对酵母菌落生长及形态的影响
Rebekah Hall,Daniel A Charlebois
Rebekah Hall
Yeasts exist in communities that expand over space and time to form complex structures and patterns. We developed a lattice-based framework to perform spatial-temporal Monte Carlo simulations of budding yeast colonies exposed to different n...
Reverse engineering of a mechanistic model of gene expression using metastability and temporal dynamics [0.03%]
基于亚稳态和时间动力学的基因表达机制模型的逆向工程
Elias Ventre
Elias Ventre
Differentiation can be modeled at the single cell level as a stochastic process resulting from the dynamical functioning of an underlying Gene Regulatory Network (GRN), driving stem or progenitor cells to one or many differentiated cell typ...
A computational framework for finding parameter sets associated with chaotic dynamics [0.03%]
一种寻找与混沌动力学相关的参数集的计算框架
S Koshy-Chenthittayil,E Dimitrova,E W Jenkins et al.
S Koshy-Chenthittayil et al.
Many biological ecosystems exhibit chaotic behavior, demonstrated either analytically using parameter choices in an associated dynamical systems model or empirically through analysis of experimental data. In this paper, we use existing soft...
Modeling and characterization of inter-individual variability in CD8 T cell responses in mice [0.03%]
小鼠CD8T细胞反应的个体间变异性的建模与表征
Chloe Audebert,Daphné Laubreton,Christophe Arpin et al.
Chloe Audebert et al.
To develop vaccines it is mandatory yet challenging to account for inter-individual variability during immune responses. Even in laboratory mice, T cell responses of single individuals exhibit a high heterogeneity that may come from genetic...