Modelling the molecular interactions in the flower developmental network of Arabidopsis thaliana [0.03%]
拟南芥花发育网络的分子相互作用模型
Kerstin Kaufmann,Masao Nagasaki,Ruy Jáuregui
Kerstin Kaufmann
We present a dynamical model of the gene network controlling flower development in Arabidopsis thaliana. The network is centered at the regulation of the floral organ identity genes (AP1, AP2, AP3, PI and AG) and ends with the transcription...
Exhaustive analysis of the modular structure of the spliceosomal assembly network: a Petri net approach [0.03%]
剪接体组装网络模块结构的详尽分析：一种Petri网方法
Ralf H Bortfeldt,Stefan Schuster,Ina Koch
Ralf H Bortfeldt
Spliceosomes are macro-complexes involving hundreds of proteins with many functional interactions. Spliceosome assembly belongs to the key processes that enable splicing of mRNA and modulate alternative splicing. A detailed list of factors ...
Role of mRNA gestation and senescence in noise reduction during the cell cycle [0.03%]
细胞周期中mRNA孕育和衰老在噪声减少中的作用
Attila Csikász-Nagy,Ivan Mura
Attila Csikász-Nagy
Recent innovations in experimental techniques on single molecule detection resulted in advances in the quantification of molecular noise in several systems, and provide suitable data for defining stochastic computational models of biologica...
Jialiang Wu,Zhen Qi,Eberhard O Voit
Jialiang Wu
Dopamine is a critical neurotransmitter for the normal functioning of the central nervous system. Abnormal dopamine signal transmission in the brain has been implicated in diseases such as Parkinson's disease (PD) and schizophrenia, as well...
On determining firing delay time of transitions for Petri net based signaling pathways by introducing stochastic decision rules [0.03%]
基于随机决策规则的Petri网信号通路中变迁点火迟延时间确定方法研究
Yoshimasa Miwa,Chen Li,Qi-Wei Ge et al.
Yoshimasa Miwa et al.
Parameter determination is important in modeling and simulating biological pathways including signaling pathways. Parameters are determined according to biological facts obtained from biological experiments and scientific publications. Howe...
Modeling of cell-to-cell communication processes with Petri nets using the example of quorum sensing [0.03%]
以群体感应为例利用petri网模型细胞间通信过程
Sebastian Janowski,Benjamin Kormeier,Thoralf Töpel et al.
Sebastian Janowski et al.
The understanding of the molecular mechanism of cell-to-cell communication is fundamental for system biology. Up to now, the main objectives of bioinformatics have been reconstruction, modeling and analysis of metabolic, regulatory and sign...
Masao Nagasaki,Ayumu Saito,Euna Jeong et al.
Masao Nagasaki et al.
Cell Illustrator is a software platform for Systems Biology that uses the concept of Petri net for modeling and simulating biopathways. It is intended for biological scientists working at bench. The latest version of Cell Illustrator 4.0 us...
Edgar Wingender
Edgar Wingender
Conformational dynamics and thermal stabilities of the alphabeta-tubulin dimer: a molecular dynamics simulation study [0.03%]
αβ-微管蛋白二聚体构象动力学及热稳定性：分子动力学模拟研究
Xiaomin Wu,Gang Yang,Yuangang Zu et al.
Xiaomin Wu et al.
Molecular dynamics simulations were employed to study the conformational dynamics and thermal stabilities of the large alphabeta-tubulin dimer systems under various conditions. The alphabeta-tubulin dimer at ambient and cryogenic temperatur...
HIV1 V3 loop hypermutability is enhanced by the guanine usage bias in the part of env gene coding for it [0.03%]
HIV-1 V3环的鸟嘌呤使用偏好增强其高变性
Vladislav Victorovich Khrustalev
Vladislav Victorovich Khrustalev
Guanine is the most mutable nucleotide in HIV genes because of frequently occurring G to A transitions, which are caused by cytosine deamination in viral DNA minus strands catalyzed by APOBEC enzymes. Distribution of guanine between three c...