In silico characterization of thermoactive, alkaline and detergent-stable lipase from a Staphylococcus aureus strain [0.03%]
一株金黄色葡萄球菌耐热、碱性及去垢剂稳定的脂肪酶的计算机表征研究
Saravanan Parameswaran,Vikash Kumar Dubey,Sanjukta Patra
Saravanan Parameswaran
Bacterial true lipases having thermo and alkaline stability are highly attractive for their industrial production of pharmaceuticals, agrochemicals, cosmetics, and flavour. Staphylococcus aureus lipase (SAL3) remains active at temperatures ...
Models for cannabinoid-1 receptor antagonistic activity of substituted 2-(3-pyrazolyl)-1,3,4-oxadiazoles [0.03%]
取代的2-(3-吡唑基)-1,3,4-噁二唑类化合物CB-1受体拮抗活性的模型研究
R Dutt,A K Madan
R Dutt
Antagonism of cannabinoid receptor-1 has emerged as a most promising therapeutic target for the development of anti-obesity drugs. In the present study, an in silico approach using decision tree, random forest and moving average analysis ha...
A computational approach for identification of epitopes in dengue virus envelope protein: a step towards designing a universal dengue vaccine targeting endemic regions [0.03%]
登革病毒包膜蛋白表位的计算识别方法——朝向针对地方性区域的通用登革热疫苗设计迈出一步
Sajib Chakraborty,Rajib Chakravorty,Musaddeque Ahmed et al.
Sajib Chakraborty et al.
A major problem in designing vaccine for the dengue virus has been the high antigenic variability in the envelope protein of different virus strains. In this study, a computational approach was adopted to identify a multi-epitope vaccine ca...
Three dimensional model for N-terminal A domain of DmpR (2-dimethylphenol) protein based on secondary structure prediction and fold recognition [0.03%]
基于二级结构预测和已知蛋白质折叠识别的DmpR蛋白N端A区三维模型
Panneer Selvam Suresh,Rita Kumar,Anil Kumar
Panneer Selvam Suresh
DmpR (dimethylphenol regulatory protein) is a member of the NtrC family of transcriptional activators and controls the transcription of the dmp operons in response to aromatic effector compounds. Secondary structure and fold recognition pre...
Overlapping genes may control reprogramming of mouse somatic cells into induced pluripotent stem cells (iPSCs) and breast cancer stem cells [0.03%]
重叠基因可能控制小鼠体细胞向诱导多能干细胞和乳腺癌干细胞的重编程
Ettore Mosca,Cinzia Cocola,Davood Sabour et al.
Ettore Mosca et al.
Recent findings suggest the possibility that tumors originate from cancer cells with stem cell properties. The cancer stem cell (CSC) hypothesis provides an explanation for why existing cancer therapies often fail in eradicating highly mali...
Judith E Risse,Jack A M Leunissen
Judith E Risse
Background: In the field of bioinformatics interchangeable data formats based on XML are widely used. XML-type data is also at the core of most web services. With the increasing amount of data stored in XML comes the need...
POODLE-I: disordered region prediction by integrating POODLE series and structural information predictors based on a workflow approach [0.03%]
基于工作流方法的POODLE系列及结构信息预测器集成的无序区域预测方法(I-POODLE)
Shuichi Hirose,Kana Shimizu,Tamotsu Noguchi
Shuichi Hirose
Under physiological conditions, many proteins that include a region lacking well-defined three-dimensional structures have been identified, especially in eukaryotes. These regions often play an important biological cellular role, although t...
Comparative Study
In silico biology. 2010;10(3):185-91. DOI:10.3233/ISB-2010-0426 2010
Konstantin Y Gorbunov,Olga N Laikova,Dmitry A Rodionov et al.
Konstantin Y Gorbunov et al.
Unlike evolution of genes and proteins, evolution of regulatory systems is a relatively new area of research. In particular, little systematic study has been done on evolution of DNA binding motifs in transcription factor families. We sugge...
Sivasankaran Sathesh-Kumar,Jayavel Sridhar,Ziauddin Ahamed Rafi
Sivasankaran Sathesh-Kumar
Bacterial small RNAs (sRNAs) have gained considerable attention due to their multivalent roles in the survival and pathogenesis of bacteria and mostly identified through bio-computational methods. A manually curated web-resource, sRNAbase h...
A combination of evolutionary trace method, molecular surface accessibility and hydrophobicity analysis to design a high hydrophobicity laccase [0.03%]
结合进化踪迹法、分子表面可及性和疏水性分析设计高疏水性漆酶
Saharuddin Bin Mohamad,Ai Ling Ong,Raja Farhana Khairuddin et al.
Saharuddin Bin Mohamad et al.
Laccases are industrially attractive enzymes and their applications have expanded to the field of bioremediation. The challenge of today's biotechnology in enzymatic studies is to design enzymes that not only have a higher activity but are ...