Identification of common tumor signatures based on gene set enrichment analysis [0.03%]
基于基因集富集分析的肿瘤共有标志的识别方法研究
Xiaosheng Wang
Xiaosheng Wang
The identification of common tumor signatures can discover the shared molecular mechanisms underlying tumorgenesis whereby we can prevent and treat tumors by a system intervention. We identified tumor-associated signatures including pathway...
Prediction of proteins putatively involved in the thiol: disulfide redox metabolism of a bacterium (Listeria): the CXXC motif as query sequence [0.03%]
含CXXC基序的蛋白质预测及对硫氧还蛋白家族在李氏菌中参与硫醇：二硫化物代谢途径的作用模式的分析
Shubha Gopal,Vanishree Srinivas,Farhan Zameer et al.
Shubha Gopal et al.
Thiol:disulfide redox metabolism (TDRM) is a central metabolic network in all living cells. However, numerous proteins with different biochemical functions and several structural domains are involved, making it not trivial to identify and a...
Challenges in the use of in silico tools for predicting peptides binding to HLA-class II molecules of HCV E1, E2, and P7 [0.03%]
基于计算方法预测HCV E1、E2和P7蛋白多肽与HLA-Ⅱ类分子结合的挑战性研究
Anton Dormer,Cathelina V Pauleus,Mondy N Syverin et al.
Anton Dormer et al.
The application of in silico tools for the development of T-cell vaccines is crucial. Yet, due to myriad of polymorphisms of human T-lymphocytic antigen challenges, such therapeutic opportunities present unique roadblocks. There is an obvio...
Analysis of Saccharomyces cerevisiae genome for the distributions of stress-response elements potentially affecting gene expression by transcriptional interference [0.03%]
利用转录干扰对基因表达影响的潜在应力反应元件分布分析：以酿酒酵母基因为例
Yunkai Liu,Sujuan Ye,Alexandre M Erkine
Yunkai Liu
Cellular stress responses are characterized by coordinated transcriptional induction of genes encoding a group of conserved proteins known as molecular chaperones, most of which are also known as heat shock proteins (HSPs). In S. cerevisiae...
Pralay Mitra,Riddhiman Dhar,Debnath Pal
Pralay Mitra
Apoptosis is a programmed mechanism of cell death that is a normal component of development and health of multi-cellular organisms. In this study, we ask if interface properties of apoptotic protein complexes are different from protein comp...
In silico analysis of T-bet activity in peripheral blood mononuclear cells in patients with inflammatory bowel disease (IBD) [0.03%]
炎症性肠病患者外周血单个核细胞中T-bet活性的计算机分析
Nielsen Q Fernandez-Becker,Alan C Moss
Nielsen Q Fernandez-Becker
T-bet (TBX21) is a transcription factor that regulates T-cell differentiation, and has recently been implicated in the pathogenesis of Crohn's disease (CD). The regulatory networks through which T-bet affects immune function are unknown. An...
Mutational bias and gene expression level shape codon usage in Thermobifida fusca YX [0.03%]
突变偏向和基因表达水平影响放线菌 Thermobifida fusca YX的密码子使用模式
Kinshuk C Nayak
Kinshuk C Nayak
In this study major factors shaping codon and amino acid usage variation in Thermobifida fusca YX are reported. It is a major degrader of plant cell walls. It produces spores that can be allergenic and has been associated with a condition c...
David B Whyte,Gopakumar Gopalakrishnan Nair,Achuthsankar S Nair et al.
David B Whyte et al.
An online tool named GEN-SNiP that identifies variations in a set of test DNA sequences with respect to a standard reference sequence is developed and deployed successfully. The tool generates a list of substitutions, insertions and deletio...
Evaluation of accuracy and applicability of protein models: retrospective analysis of biological and biomedical predictions [0.03%]
蛋白质模型的精度和适用性评估：生物学和生物医学预测的回顾分析
Sofia Khan,Mauno Vihinen
Sofia Khan
In order to study protein function and activity structural data is required. Since experimental structures are available for just a small fraction of all known protein sequences, computational methods such as protein modelling can provide u...
K Ecker,L Welch
K Ecker
An important concern in the attempt of understanding the functional code of eukaryotic genes is to elucidate the control structures for regulating gene activation and suppression. One objective in the attempt to understand mechanisms of gen...