Nicholas Mancuso,Bassam Tork,Pavel Skums et al.
Nicholas Mancuso et al.
This paper addresses the problem of reconstructing viral quasispecies from next-generation sequencing reads obtained from amplicons (i.e., reads generated from predefined amplified overlapping regions). We compare the parsimonious and likel...
Mixture model analysis reflecting dynamics of the population diversity of 2009 pandemic H1N1 influenza virus [0.03%]
反映2009年甲型H1N1流感病毒人群多样性动态的混合模型分析
Li-Ping Long,Changhe Yuan,Zhipeng Cai et al.
Li-Ping Long et al.
Influenza A viruses have been responsible for large losses of lives around the world and continue to present a great public health challenge. In April 2009, a novel swine-origin H1N1 virus emerged in North America and caused the first pande...
Coordinated evolution among hepatitis C virus genomic sites is coupled to host factors and resistance to interferon [0.03%]
与宿主因素和干扰素耐药性相耦合的丙型肝炎病毒基因组各部位协调进化
James Lara,John E Tavis,Maureen J Donlin et al.
James Lara et al.
Machine-learning methods in the form of Bayesian networks (BN), linear projection (LP) and self-organizing tree (SOT) models were used to explore association among polymorphic sites within the HVR1 and NS5a regions of the HCV genome, host d...
Association of antigenic properties to structure of the hepatitis C virus NS3 protein [0.03%]
抗原特性与丙型肝炎病毒NS3蛋白结构的关系
James Lara,Yury Khudyakov
James Lara
Sequence heterogeneity substantially affects antigenic properties of the major epitope in the hepatitis C virus (HCV) NS3 protein. To facilitate protein engineering of NS3 antigens immunologically reactive with antibody against the broad di...
QColors: an algorithm for conservative viral quasispecies reconstruction from short and non-contiguous next generation sequencing reads [0.03%]
QColors：一种从短的和非连续的下一代测序读段中保守地重建病毒准种系谱的算法
Austin Huang,Rami Kantor,Allison DeLong et al.
Austin Huang et al.
Next generation sequencing technologies have recently been applied to characterize mutational spectra of the heterogeneous population of viral genotypes (known as a quasispecies) within HIV-infected patients. Such information is clinically ...
Evaluation of viral heterogeneity using next-generation sequencing, end-point limiting-dilution and mass spectrometry [0.03%]
基于下一代测序、终点限稀释和质谱评估病毒异质性
Z Dimitrova,D S Campo,S Ramachandran et al.
Z Dimitrova et al.
Hepatitis C Virus sequence studies mainly focus on the viral amplicon containing the Hypervariable region 1 (HVR1) to obtain a sample of sequences from which several population genetics parameters can be calculated. Recent advances in seque...
D S Campo,Z Dimitrova,J Lara et al.
D S Campo et al.
The detection of compensatory mutations that abrogate negative fitness effects of drug-resistance and vaccine-escape mutations indicates the important role of epistatic connectivity in evolution of viruses, especially under the strong selec...
Differences in variability of hypervariable region 1 of hepatitis C virus (HCV) between acute and chronic stages of HCV infection [0.03%]
丙型肝炎病毒(HCV)感染急性期与慢性期病毒变异性的差异分析——HVR1区的序列多态性研究
I V Astrakhantseva,D S Campo,A Araujo et al.
I V Astrakhantseva et al.
Distinguishing between acute and chronic HCV infections is clinically important given that early treatment of infected patients leads to high rates of sustained virological response. Analysis of 2179 clonal sequences derived from hypervaria...
ANDVisio: a new tool for graphic visualization and analysis of literature mined associative gene networks in the ANDSystem [0.03%]
ANDVisio：一种新的图形可视化和分析文献挖掘的基因关联网络工具
P S Demenkov,T V Ivanisenko,N A Kolchanov et al.
P S Demenkov et al.
The ANDVisio tool is designed to reconstruct and analyze associative gene networks in the earlier developed Associative Network Discovery System (ANDSystem) software package. The ANDSystem incorporates utilities for automated extraction of ...
Towards a virtual C. elegans: a framework for simulation and visualization of the neuromuscular system in a 3D physical environment [0.03%]
迈向虚拟线虫：在三维物理环境中模拟和可视化神经肌肉系统的框架
Andrey Palyanov,Sergey Khayrulin,Stephen D Larson et al.
Andrey Palyanov et al.
The nematode C. elegans is the only animal with a known neuronal wiring diagram, or "connectome". During the last three decades, extensive studies of the C. elegans have provided wide-ranging data about it, but few systematic ways of integr...