Cellular automata model for human articular chondrocytes migration, proliferation and cell death: An in vitro validation [0.03%]
人软骨细胞迁移、增殖和细胞凋亡的元胞自动机模型及体外验证
J J Vaca-González,M L Gutiérrez,J M Guevara et al.
J J Vaca-González et al.
Articular cartilage is characterized by low cell density of only one cell type, chondrocytes, and has limited self-healing properties. When articular cartilage is affected by traumatic injuries, a therapeutic strategy such as autologous cho...
A simple model for Lutz and Bujard's controllable promoters and its application for analyzing a simple genetic oscillator [0.03%]
一个简单的Lutz-Bujard可控启动子模型及其在简单遗传振荡器分析中的应用
C G Zamora-Chimal,E S Zeron
C G Zamora-Chimal
We develop an exact and flexible mathematical model for Lutz and Bujard's controllable promoters. It can be used as a building block for modeling genetic systems based on them. Special attention is paid to deduce all the model parameters fr...
Exploiting stoichiometric redundancies for computational efficiency and network reduction [0.03%]
利用计量冗余度提高计算效率和网络简化能力
Brian P Ingalls,Eric Bembenek
Brian P Ingalls
Analysis of metabolic networks typically begins with construction of the stoichiometry matrix, which characterizes the network topology. This matrix provides, via the balance equation, a description of the potential steady-state flow distri...
The utility of simple mathematical models in understanding gene regulatory dynamics [0.03%]
简单数学模型在理解基因调控动态中的作用
Michael C Mackey,Moisés Santillán,Marta Tyran-Kamińska et al.
Michael C Mackey et al.
In this review, we survey work that has been carried out in the attempts of biomathematicians to understand the dynamic behaviour of simple bacterial operons starting with the initial work of the 1960's. We concentrate on the simplest of si...
In silico analysis of division times of Escherichia coli populations as a function of the partitioning scheme of non-functional proteins [0.03%]
非功能性蛋白质分配方案对大肠杆菌种群分裂时间的计算机分析
Abhishekh Gupta,Jason Lloyd-Price,Andre S Ribeiro
Abhishekh Gupta
Recent evidence suggests that cells employ functionally asymmetric partitioning schemes in division to cope with aging. We explore various schemes in silico, with a stochastic model of Escherichia coli that includes gene expression, non-fun...
Dennis Bray
Dennis Bray
Are we close to a complete inventory of living processes so that we might expect in the near future to reproduce every essential aspect necessary for life? Or are there mechanisms and processes in cells and organisms that are presently inac...
miRNA-mRNA network detects hub mRNAs and cancer specific miRNAs in lung cancer [0.03%]
基于肺癌的miRNA-mRNA网络鉴定关键mRNAs及癌症特异性miRNAs
Saranya Devaraj,Jeyakumar Natarajan
Saranya Devaraj
MicroRNA expression profiles can improve classification, diagnosis, and prognostic information of malignancies, including lung cancer. In this paper, we undertook to develop a miRNA-mRNA network and uncover unique growth suppressive miRNAs ...
Molecular modeling and docking analysis of beta-lactamases with inhibitors: a comparative study [0.03%]
β-内酰胺酶与抑制剂的分子模拟及对接分析：一项比较研究
Mohd Danishuddin,Asad U Khan
Mohd Danishuddin
Beta-lactamases are bacterial enzymes which impart resistance against β-lactam-antibiotics. CTX-Ms are the β-lactamases that target cephalosporin antibiotics (e.g. cefotaxime and ceftazidime) while SME-1, KPC-2, IMI-1 and SFC-1 target car...
Numerical detection, measuring and analysis of differential interferon resistance for individual HCV intra-host variants and its influence on the therapy response [0.03%]
针对单个HCV克隆的干扰素差异性抗病毒活性的数值检测、测量及分析及其对治疗反应的影响
Pavel Skums,David S Campo,Zoya Dimitrova et al.
Pavel Skums et al.
Hepatitis C virus (HCV) is a major cause of liver disease world-wide. Current interferon and ribavirin (IFN/RBV) therapy is effective in 50%-60% of patients. HCV exists in infected patients as a large viral population of intra-host variants...
Improved transcriptome quantification and reconstruction from RNA-Seq reads using partial annotations [0.03%]
利用部分注释信息改进RNA序列读段的转录组定量和重构技术
Serghei Mangul,Adrian Caciula,Olga Glebova et al.
Serghei Mangul et al.
The paper addresses the problem of how to use RNA-Seq data for transcriptome reconstruction and quantification, as well as novel transcript discovery in partially annotated genomes. We present a novel annotation-guided general framework for...