Fatemeh Tavakoli,Javad Salimi Sartakhti,Mohammad Hossein Manshaei et al.
Fatemeh Tavakoli et al.
The role of the immune system in tumor development increasingly includes the idea of cancer immunoediting. It comprises three phases: elimination, equilibrium, and escape. In the first phase, elimination, transformed cells are recognized an...
Dynamical modeling of pro- and anti-inflammatory cytokines in the early stage of septic shock [0.03%]
脓毒性休克早期促炎和抗炎细胞因子的动态模型研究
J Tallon,B Browning,F Couenne et al.
J Tallon et al.
A dynamical model of the pathophysiological behaviors of IL18 and IL10 cytokines with their receptors is tested against data for the case of early sepsis. The proposed approach considers the surroundings (organs and bone marrow) and the dif...
A computational model of bidirectional axonal growth in micro-tissue engineered neuronal networks (micro-TENNs) [0.03%]
微组织工程神经网络（micro-TENN）中轴突双向生长的计算模型
Toma Marinov,Haven A López Sánchez,Liang Yuchi et al.
Toma Marinov et al.
Micro-Tissue Engineered Neural Networks (Micro-TENNs) are living three-dimensional constructs designed to replicate the neuroanatomy of white matter pathways in the brain and are being developed as implantable micro-tissue for axon tract re...
Maria Krantz,Edda Klipp
Maria Krantz
Moonlighting refers to a protein with at least two unrelated, mechanistically different functions. As a concept, moonlighting describes a large and diverse group of proteins which have been discovered in a multitude of organisms. As of toda...
Lower connectivity of tumor coexpression networks is not specific to cancer [0.03%]
肿瘤共表达网络的低连通性并不特异于癌症
Ertuğrul Dalgıç,Özlen Konu,Zehra Safi Öz et al.
Ertuğrul Dalgıç et al.
Global level network analysis of molecular links is necessary for systems level view of complex diseases like cancer. Using genome-wide expression datasets, we constructed and compared gene co-expression based specific networks of pre-cance...
Calibration, Selection and Identifiability Analysis of a Mathematical Model of the in vitro Erythropoiesis in Normal and Perturbed Contexts [0.03%]
正常和受干扰条件下体外红细胞发育过程的数学模型标定、选择及可辨识性分析
Ronan Duchesne,Anissa Guillemin,Fabien Crauste et al.
Ronan Duchesne et al.
The in vivo erythropoiesis, which is the generation of mature red blood cells in the bone marrow of whole organisms, has been described by a variety of mathematical models in the past decades. However, the in vitro erythropoiesis, which pro...
Daniel A Charlebois,Gábor Balázsi
Daniel A Charlebois
Quantitative modeling is quickly becoming an integral part of biology, due to the ability of mathematical models and computer simulations to generate insights and predict the behavior of living systems. Single-cell models can be incapable o...
A hybrid multiscale model for investigating tumor angiogenesis and its response to cell-based therapy [0.03%]
一种研究肿瘤血管生成及其对细胞治疗反应的混合多尺度模型
Melisa Hendrata,Janti Sudiono
Melisa Hendrata
Angiogenesis, a formation of blood vessels from an existing vasculature, plays a key role in tumor growth and its progression into cancer. The lining of blood vessels consists of endothelial cells (ECs) which proliferate and migrate, allowi...
Christoph Leberecht,Florian Heinke,Dirk Labudde
Christoph Leberecht
A variety of mathematical models is used to describe and simulate the multitude of natural processes examined in life sciences. In this paper we present a scalable and adjustable foundation for the simulation of natural systems. Based on ne...
Differential transcriptional regulation by alternatively designed mechanisms: A mathematical modeling approach [0.03%]
基于不同设计机制的差异转录调控的数学建模方法研究
Necmettin Yildirim,Mehmet Emin Aktas,Seyma Nur Ozcan et al.
Necmettin Yildirim et al.
Cells maintain cellular homeostasis employing different regulatory mechanisms to respond external stimuli. We study two groups of signal-dependent transcriptional regulatory mechanisms. In the first group, we assume that repressor and activ...