Achieving Diverse Functionalizations of Electron-Deficient Aryl Halides via Carbonate-Mediated Electron-Donor-Acceptor Complexes [0.03%]
通过碳酸盐介导的给电子-吸电子复合物实现缺电子芳基卤化物的多样性官能团化反应
Krishnakumar Sachidanandan,Cole Stenftenagel,Athul Joshy et al.
Krishnakumar Sachidanandan et al.
Aryl halides are excellent precursors for functional group interconversion due to their malleability and diversity. They are also among the most common building blocks due to their use in cross-coupling reactions. Traditional methodologies ...
Additives Promote Divergent Reactivity in Photolytic Deoxygenation and Lactonization Reactions of Cobalt Alkoxycarbonyls [0.03%]
添加剂促进钴烷氧基羰基化合物光解脱氧和内酯化反应的发散式化学反应性
Jacob N Hackbarth,Dana R Chambers,Cory T Ludwig et al.
Jacob N Hackbarth et al.
The formation of lactones via radical-mediated C─C bond formation is a powerful but overlooked method, especially given recent interest in the conversion of alcohols to radical intermediates using photochemistry. Building on our previous w...
EDA Complex-Mediated C(sp3)-H Cross-Dehydrogenative Coupling Enables Synthesis of Noncanonical α, β-Diamino Acids [0.03%]
基于EDA复合物介导的C(sp³)-H交叉脱氢偶联反应实现非经典α,β-二氨基酸合成
Krishnakumar Sachidanandan,Cole Stenftenagel,Athul Joshy et al.
Krishnakumar Sachidanandan et al.
Nonproteinogenic α,β-diamino acids are key motifs in bioactive compounds. We report a photoinduced cross-dehydrogenative coupling (CDC) of N-arylglycine derivatives with amides. This reaction proceeds via an electron donor-acceptor (EDA) ...
Cu-NHC Complex for Chan-Evans-Lam Cross-Coupling Reactions of N-Heterocyclic Compounds and Arylboronic Acids [0.03%]
含N-杂环卡宾的铜催化剂用于N-杂环化合物与芳基硼酸的Chan-Evans-Lam交叉偶联反应
Bhupendra Adhikari,Mohsen Teimouri,James W Akin et al.
Bhupendra Adhikari et al.
An efficient copper(II) N-heterocyclic carbene (NHC) complex with an NCN coordination mode was optimized to catalyze the Chan-Evans-Lam (CEL) cross-coupling reaction of imidazole and other N-heterocyclic nucleophiles with arylboronic acid. ...
Mohammed K Abd El-Gaber,Mario Djugovski,Tzu-Yu Huang et al.
Mohammed K Abd El-Gaber et al.
Incorporating fluorine into azoles is not only a common practice but also an essential tactic in medicinal chemistry, due to their ability to fine-tune a molecule's physicochemical, pharmacokinetic, and pharmacodynamic profiles. The strateg...
Total Synthesis of Tabernanthine and Ibogaline: Rapid Access to Nosyl Tryptamines [0.03%]
长春花生物碱盐酸塔巴宁因和伊博加因的全合成：Nosyl-氯乙基衍生物高效制备苦杏仁酸缩氨酶类生物碱的新策略
Alexander J Hughes,Steven D Townsend
Alexander J Hughes
We describe the first total syntheses of tabernanthine and ibogaline. Entry to these iboga alkaloid natural products is enabled by a thermal coupling of indoles and aziridines to furnish the requisite nosyl tryptamine starting materials. Th...
Disrupting Substance Use Disorder: The Chemistry of Iboga Alkaloids [0.03%]
_IBOGA 碱对人体物质使用障碍的干预作用及其化学机理分析_
Alexander J Hughes,Charles R Hamelink,Steven D Townsend
Alexander J Hughes
The iboga alkaloids are a family of monoterpene indole alkaloids first discovered from the root of Tabernanthe iboga. The major alkaloid constituent in the root, ibogaine, has garnered interest for its anti-addictive properties. Ibogaine ha...
Elucidating Fluorine Steering Effects in Diels-Alder Reactions Interfaced with Charge-Enhanced Reactivity [0.03%]
揭示介电负增强反应活性的狄尔斯-阿尔德反应中的氟导向效应
Sabrina Hoford,Julius Jan,Jeffrey N Johnston et al.
Sabrina Hoford et al.
Fluorinated molecules are core to contemporary drug discovery programs and critical for advancing innovation in numerous fields. In merging these important chemical themes, fluorinated Diels-Alder cycloaddition products are a particularly a...
Lukas S Vogl,Matthias Bechmann,Mario Waser
Lukas S Vogl
Isothioureas (ITUs) represent a powerful family of (chiral) Lewis base organocatalysts. Interestingly, the Brønsted basicity of these frequently used compounds has so far not systematically been investigated. Thus, we have now determined t...
Exploring Interrupted Nazarov Cyclizations Using Tethered Sulfonamide Nucleophiles: Insights into Capture Pathways [0.03%]
带有连接磺酰胺亲核试剂的Nazarov环化中断的研究：捕获途径的见解
Aleksa Milosavljevic,Jackson J Hernandez,Patrycia K Zybura et al.
Aleksa Milosavljevic et al.
This manuscript describes a study of diverse reaction outcomes that stem from the ionization of aza-alkynyl-Prins adducts. Experimental results have demonstrated unexpected behavior in the nitrogen-containing systems compared to the analogo...