Discovery metabolomics and genetic analysis reveal lipid pathway alterations associated with malignant phenotype acquisition in pleomorphic adenoma and a novel NTF3::ITPR2 fusion in carcinoma ex pleomorphic adenoma [0.03%]
发现代谢组学和遗传分析揭示了多形性腺瘤恶性表型获得相关的脂质途径改变以及腺瘤性癌中的一种新的NFT3 :: ITPR2融合基因
Reydson Alcides de Lima-Souza,Talita de Carvalho Kimura,João Figueira Scarini et al.
Reydson Alcides de Lima-Souza et al.
Pleomorphic adenoma (PA) is the most common salivary gland tumor. Although it is benign, PA may recur, metastasize, and undergo malignant transformation into carcinoma ex pleomorphic adenoma (CXPA). The mechanisms underlying this transforma...
FOS gene fusions in osteosarcoma raise the hypothesis of malignant transformation of osteoblastoma [0.03%]
骨肉瘤中的FOS基因融合提出了成骨细胞瘤恶变的假说
Christophe Bontoux,Marie Csanyi-Bastien,Corinne Bouvier et al.
Christophe Bontoux et al.
Osteosarcoma is the most common malignant bone tumor among children and young adults. Distinguishing between osteoblastoma and osteosarcoma can be particularly challenging, especially in small tissue samples and for the osteoblastoma-like o...
STR genotyping diagnosis of hydatidiform moles: an assessment of 2871 consecutive products of conceptions [0.03%]
完全流产产物组织STR分型检测诊断葡萄胎价值的研究（2871例分析）
Razie Amraei,Na Niu,Mitchel Clark et al.
Razie Amraei et al.
This study evaluated the incidence of hydatidiform moles in a tertiary care setting and examined the efficacy of short tandem repeat genotyping (STR) as a primary ancillary diagnostic tool for molar gestations. Consecutive products of conce...
Undifferentiated melanoma: a molecular study of a fatal metastatic "atypical fibroxanthoma (AFX)" [0.03%]
未分化黑色素瘤的分子研究——一例致命转移性“非典型纤维组织细胞增生(AFX)”
Simon Haefliger,Baptiste Ameline,Veronika Blum et al.
Simon Haefliger et al.
Diagnosing undifferentiated spindle cell and pleomorphic tumours of the sun-exposed skin of elderly patients is common and challenging. This paper presents the case of a 64-year-old man with a tumour that was initially diagnosed as an atypi...
Uterine mesenchymal tumour with a novel EWSR1::CTBP1 gene fusion [0.03%]
带有新型EWSR1::CTBP1基因融合的子宫间叶组织肿瘤
Beata Bode-Lesniewska,Frank Illigen,Matthias S Matter
Beata Bode-Lesniewska
A growing number of mesenchymal uterine tumours are defined by a specific molecular aberration. We present the case of a 65-year-old woman who presented with postmenopausal bleeding and a large intramural uterine tumour. Histopathological a...
Methylation profiling: a diagnostic tool for the diagnosis of Merkel cell carcinoma of the lymph node without detectable skin primary tumor [0.03%]
甲基化谱分析：诊断未检出皮肤原发瘤的淋巴结默克尔细胞癌的诊断工具
Paul-Louis Chantreau,Pierre Sohier,Mahtab Samimi et al.
Paul-Louis Chantreau et al.
Merkel cell carcinoma (MCC) is an aggressive tumor mostly related to Merkel cell polyomavirus genomic integration. MCC can present either as a primary cutaneous tumor or as a lymph node metastasis without a primary skin tumor (MCCWOPT). The...
Daniel Arizpe,Alexander J Gallan,Adam M Kase et al.
Daniel Arizpe et al.
Anaplastic lymphoma kinase-rearranged renal cell carcinoma (ALK-RCC) is a rare and recently recognized molecular subtype of RCC defined by ALK gene fusions. We describe five ALK-RCC and one likely ALK-rearranged epithelioid mesenchymal neop...
Instant confocal histology for the evaluation of kidney transplant procurement biopsies [0.03%]
用于肾脏移植获取活检的即时共聚焦组织学评价
Angela Ernst,Volker Aßfalg,Wolfgang Arns et al.
Angela Ernst et al.
Prognostic outcome models might help to minimise the discard rates of renal transplants from deceased donors. To this end, we published 2-Step Scores for both delayed graft function and transplant loss with optional histology. With conventi...
Utility of quantitative pathologic analysis of pT1 colorectal carcinomas to improve prediction of lymph node metastasis [0.03%]
定量病理分析pT1期结直肠癌的实用性以改善淋巴结转移的预测能力
Priya Nayak,Heidi Kosiorek,Reetesh K Pai et al.
Priya Nayak et al.
According to the National Comprehensive Cancer Network (NCCN), submucosally invasive (pT1) colorectal carcinomas (CRCs) should be evaluated for tumor grade, lymphatic invasion, and tumor budding to determine the risk of lymph node metastasi...
Calcifying nested stromal-epithelial tumor of the liver: Report of two cases revealing novel WT1 mutation and distinct epigenetic features [0.03%]
肝钙化性间叶上皮瘤两例报告并发现新型WT1基因突变及表观遗传学特点
Andrea Strakova-Peterikova,Franco Fedeli,Boris Rychly et al.
Andrea Strakova-Peterikova et al.
Calcifying nested stromal-epithelial tumor (CNSET) is an extremely rare primary liver tumor of uncertain histogenesis that predominantly occurs in the pediatric age group and young adults. Knowledge regarding the molecular genetic profile o...