Orthogonal validation of anaplastic lymphoma kinase (ALK) immunohistochemistry with molecular analysis for ALK gene rearrangement is required to finetune staining protocols with the D5F3 clone and can impact external quality assessment [0.03%]
采用分子分析验证间变性淋巴瘤激酶（ALK）免疫组化与ALK基因重排的关系以调整D5F3克隆染色方案并影响外部质量评估
Ibrahim Kassem,Cyril Van Essche,Delphine Hoton et al.
Ibrahim Kassem et al.
Immunohistochemistry (IHC) for anaplastic lymphoma kinase (ALK) is used to screen tumours for ALK gene rearrangements, which generally result in ALK protein overexpression, depending on the fusion partner. Here, an interlaboratory validatio...
Skin-analogue primary poroid neoplasms of the head and neck with YAP1/WWTR1::MAML2/NUTM1 fusions: clinicopathologic and genetic spectrum of a novel tumor family delineated in a series of 10 cases [0.03%]
头颈部类皮肤原发Poroid肿瘤伴YAP1/WWTR1::MAML2/NUTM1融合：10例系列报道中的临床病理及遗传谱系特征描述一种新型肿瘤家族
Abbas Agaimy,Elan Hahn,Juan C Hernandez-Prera et al.
Abbas Agaimy et al.
Porocarcinoma is a rare type of aggressive skin adnexal carcinoma with terminal sweat duct differentiation, representing the malignant counterpart of the more common benign eccrine poroma. Diagnosis is based on distinctive morphology, suppl...
Molecular classification-driven stage migration and prognostic risk stratification in endometrial cancers: FIGO 2023 vs FIGO 2009 [0.03%]
基于分子分型的子宫内膜癌FIGO 2023与FIGO 2009分期迁移及预后风险分层的对比分析
Neha Bakshi,Rahul Modi,Vandana Arya et al.
Neha Bakshi et al.
The FIGO 2023 staging system of endometrial cancers (ECs) encourages integration of molecular classification with traditional histopathologic parameters for better prognostication and improved treatment decisions; however, limited availabil...
Endometrial carcinomas with solid basaloid morphology and geographic necrosis: clinicopathological and molecular features of 18 cases [0.03%]
实体基底样型伴地理型坏死的子宫内膜癌临床病理及分子特征(18例报告)
Mengyuan Cai,Tian Tang,Rui Bi et al.
Mengyuan Cai et al.
Pilomatrix-like high-grade endometrioid carcinoma (PiMHEC) is characterized by solid basaloid morphology, geographic necrosis, and shadow cells, often associated with CTNNB1 mutations and aberrant β-catenin expression, exhibiting aggressiv...
Abnormal nuclear and nucleolar immunoreactivity of p16INK4a represents a frameshift alteration in CDKN2A: the E6H4 clone recognizes the "p14ARF::p16INK4a" chimeric protein [0.03%]
P16INK4a蛋白的异常核和核仁免疫反应代表了CDKN2A基因的移码突变：E6H4克隆识别P14ARF::P16INK4a融合蛋白
Ayaka Mitsui,Jumpei Kashima,Eijitu Ryo et al.
Ayaka Mitsui et al.
In p16INK4a immunostaining, block positivity (i.e., strong nuclear/nuclear-cytoplasmic staining) is a widely acknowledged surrogate marker of HPV-associated cancers. Thus, immunohistochemistry using the anti-p16INK4a clone E6H4 has been app...
Acquired MYC rearrangement potentially associated with ibrutinib resistance in mantle cell lymphoma [0.03%]
MYC重排与套细胞淋巴瘤伊布替尼耐药性获得有关的可能性
Chang-Tsu Yuan,Li-Yu Sun,Chieh-Lung Cheng et al.
Chang-Tsu Yuan et al.
Mantle cell lymphoma (MCL) is a subtype of mature B-cell lymphoma characterized by the expression of CD5, cyclin D1, and SOX11, along with the IGH::CCND1 rearrangement. While the introduction of ibrutinib, a Bruton tyrosine kinase inhibitor...
Sinonasal DICER1‑mutated embryonal-like (botryoid-like) rhabdomyosarcoma in an adult: report of the first case [0.03%]
成人鼻窦性DICER1突变型胚胎样（葡萄状）横纹肌肉瘤一例报告
Miguel Rito,Sofia Fernandes,Robert Stoehr et al.
Miguel Rito et al.
The DICER1 gene, essential for microRNA biogenesis and posttranscriptional gene regulation, has been implicated in a variety of benign and malignant neoplasms, particularly within the context of the DICER1-related tumor predisposition syndr...
Utility of HoxB13 in differential diagnosis of female genital tract lesions with putative prostatic differentiation [0.03%]
HoxB13在疑似前列腺分化型女性生殖道病变鉴别诊断中应用价值的研究
Lucie Gerykova,Jan Laco,Helena Hornychova et al.
Lucie Gerykova et al.
Female genital tract lesions with putative prostatic differentiation include vaginal tubulosquamous polyp (TSP), cervical ectopic prostatic tissue (EPT), and adenoid basal carcinoma (ABC). HoxB13 is a transcription factor specific for the p...
Cytopathologic features of mesonephric-like adenocarcinoma in the endometrium and ovary: eight cases and literature review [0.03%]
子宫和卵巢中间肾小管腺癌的细胞病理特征八例报告及文献回顾
Lei Qin,Wanrun Lin,Xin Zhou et al.
Lei Qin et al.
Mesonephric-like adenocarcinoma (MLA) is rare and clinically aggressive. Previous studies have characterized the histologic, immunohistochemical, and molecular features of MLA; however, there is limited information regarding its cytological...
Submucosal gland duct adenoma of the esophagus: expanding the morphologic spectrum of a rare tumor entity [0.03%]
罕见肿瘤的形态谱系扩展：食管固有腺瘤
Hongjin Hua,Ying Ding,Jinxing Zhang et al.
Hongjin Hua et al.
Esophageal submucosal gland duct adenoma (ESGDA) is an extremely rare benign tumor originating from the esophageal ducts, resembling sialadenoma papilliferum (SP) of the minor salivary glands. However, the clinicopathological and molecular ...