Comment on "FOXL2 expression in dysgenetic gonads supports the diagnostic possibility of ovotesticular differences of sex development" [0.03%]
关于“FOXL2在发育不良性腺中的表达支持卵巢睾丸性发育差异诊断的可能性”的评论
Madhuri Tribhuvan,Shashikant N Phatke
Madhuri Tribhuvan
Study of inborn errors of immunity associated lymphoid proliferations identifies association of presence of somatic variations with large cell morphology, copy number alterations in TNFAIP3 and heterozygous variants in EMSY [0.03%]
关于免疫缺陷相关淋巴增生的研究发现体细胞变异的存在与大细胞形态、TNFAIP3拷贝数改变以及EMSY杂合变异有关
Arzu Saglam,Jyoti Kumar,Jessica Van Ziffle et al.
Arzu Saglam et al.
Lymphoproliferative disorders (LPDs) associated with inborn errors of immunity (IEI) are rare entities and their genetic basis is not well defined. We performed targeted deep sequencing using a panel of 529 genes to investigate the single n...
Diagnostic utility of novel marker TRIM63 ISH in the workup of uterine perivascular epithelioid cell tumors [0.03%]
新型标志物TRIM63 ISH在子宫血管周上皮样细胞肿瘤诊断中的应用价值
Phoebe M Hammer,Brooke Liang,Teri Longacre et al.
Phoebe M Hammer et al.
Among soft tissue tumors, TRIM63 in situ hybridization (ISH) represents an emerging biomarker often positive in alveolar soft part sarcoma (ASPS) and perivascular epithelioid cell tumor (PEComa). However, its expression among gynecological ...
Cribriform morular thyroid carcinoma with EWSR1 gene rearrangement, TERT promoter mutation, and somatic variant of APC [0.03%]
具有EWSR1基因重排、TERT启动子突变和APC体细胞变异筛孔样甲状腺癌
Mohammed Sayel Alorjani,Manuel Sobrinho-Simões,Ayat Nader Al-Oqaily et al.
Mohammed Sayel Alorjani et al.
Cribriform morular thyroid carcinoma (CMTC) is a rare neoplasm more common in young euthyroid females, usually associated with familial adenomatous polyposis (FAP) syndrome, but also presenting as sporadic cases. These tumors result from th...
Immunohistochemical characterization of somatically derived "yolk sac tumors": analysis of a multi-institutional case series [0.03%]
对多中心病例系列中体细胞来源的“卵黄囊瘤”的免疫组化特征分析
Costantino Ricci,Antonio De Leo,Marco Grillini et al.
Costantino Ricci et al.
A rare subset of somatic tumors shows a striking resemblance to yolk sac tumors (YSTs) of germ cell origin, including somatic carcinomas with YST/enteroblastic differentiation, fetal lung adenocarcinomas (FLACs), and YSTs in older (≥ 40 ye...
From synoptic to structured reporting: real-world implementation and evaluation of a pathology reporting tool in lung cancer [0.03%]
从综合报告到结构化报告：肺癌病理报告工具的真实世界实施和评估
Martina Haberecker,Pauline Kürten,Chantal Pauli
Martina Haberecker
Structured reporting in pathology can enhance data quality and interoperability through standardized terminologies; however, its integration into routine practice remains limited as structured reporting systems are frequently perceived as d...
Association between CD79B expression and polatuzumab vedotin efficacy, and therapy-induced changes in CD79B expression in diffuse large B-cell lymphoma [0.03%]
CD79B表达与Polatuzumab Vedotin疗效之间的关系以及治疗引起的DLBCL中CD79B表达变化
Yuto Kaimi,Yuka Takahashi,Mai Takeuchi et al.
Yuto Kaimi et al.
Polatuzumab vedotin (PV), a CD79B-directed antibody-drug conjugate, is approved for treating diffuse large B-cell lymphoma (DLBCL). However, the clinical relevance of CD79B expression and the frequency of loss or decrease after PV-containin...
High performance deep-learning model for the diagnosis of auto-immune hepatitis based on histological whole slide images [0.03%]
基于组织病理整片图像的自身免疫性肝炎诊断深度学习模型
Pierre Allaume,Noémie Rabilloud,Anna Sessa et al.
Pierre Allaume et al.
Autoimmune Hepatitis (AIH) is a liver disease with a wide clinical spectrum, driven by an abnormal immune response against the liver parenchyma. Challenges persist especially in terms of accurate diagnosis of acute onsets and differential d...
Prognostic significance of histopathologically assessed tumor mitotic rate in T1-T4 cutaneous melanoma in the AJCC 8th edition era (2018-2022) [0.03%]
AJCC第8版分期（2018-2022年）T1-T4皮肤黑色素瘤的组织病理评估肿瘤有丝分裂率预后意义
Rabia Hursitoglu,Erhan Kaya
Rabia Hursitoglu
Cutaneous melanoma (CM) is a highly metastatic malignancy where accurate risk stratification is vital for prognosis. Although tumor mitotic rate (TMR) was removed from T1 staging in the AJCC 8th edition, it remains a critical marker of prol...
Immunohistochemical characterization of the tumor immune microenvironment in laryngeal premalignancy: insights into early immune alterations in carcinogenesis [0.03%]
喉部癌前病变肿瘤免疫微环境的免疫组织化学特征分析：探讨癌症发生早期的免疫改变
Mario Berríos,Blanca Vivanco,Juan Pablo Rodrigo et al.
Mario Berríos et al.
Laryngeal squamous cell carcinoma (LSCC) frequently arises from premalignant dysplastic lesions, yet reliable predictors of malignant transformation remain limited. This study investigates the immune microenvironment of laryngeal dysplasia ...