Integrative diagnostic approach to salivary gland tumors: from clinical evaluation to molecularly targeted therapy [0.03%]
综合诊断方法在涎腺肿瘤中的应用：从临床评估到分子靶向治疗
Anna Luíza Damaceno Araújo,Reydson Alcides Lima-Souzade Lima-Souza,Fernanda Viviane Mariano et al.
Anna Luíza Damaceno Araújo et al.
Diagnosing salivary gland tumors remains challenging due to their clinical and biological complexity, histopathologic diversity, and overlapping morphology. Over the last few years, molecular profiling has emerged as a key tool for improvin...
Central histopathological review of a European hepatocellular carcinoma cohort: impact of the WHO 2019 classification on histological diagnosis and TNM staging [0.03%]
欧洲肝细胞癌队列的中心病理学审查：世界卫生组织2019年分类对组织学诊断和TNM分期的影响
Konstantina Dimopoulou,Despoina Myoteri,John Contis et al.
Konstantina Dimopoulou et al.
The World Health Organization (WHO) 2019 classification of hepatocellular carcinoma (HCC) introduces new histological subtypes aiding morphomolecular classification. We aimed to reclassify and restage archival HCC following central patholog...
Polyarteritis nodosa presenting with pancreatic-artery rupture and co-existing MEFV and ADA2 mutation: clinicopathological and genomic insights from a case report [0.03%]
以胰腺动脉瘤破裂和MEFV及ADA2基因突变共存为表现的多动脉炎病例报告及相关临床病理学和基因组研究
Jiaqing Luo,Jiawei Ming,Chunmiao Lin et al.
Jiaqing Luo et al.
Polyarteritis nodosa (PAN) is an uncommon medium-vessel vasculitis; pancreatic arterial rupture is an exceptionally rare and life-threatening manifestation. A previously healthy 70-year-old man developed progressive abdominal distension fol...
A rare cystic and papillary variant of acinar cell carcinoma with liver metastasis and molecular analysis [0.03%]
具有肝转移的罕见囊性乳头状腺泡细胞癌变异型及分子分析
Meredith K Herman,Eric Chang,Jiaqi Shi
Meredith K Herman
Acinar cell carcinoma (ACC) is a pancreatic neoplasm with histologic variants that pose significant diagnostic challenges. We report a 75-year-old man with a previously unreported cystic and papillary ACC metastatic to the liver. Histologic...
Superficial CD34-positive fibroblastic tumor with locoregional metastasis: a case report [0.03%]
浅表CD34阳性成纤维细胞肿瘤伴区域转移1例报告
Sintawat Wangsiricharoen,Wendong Yu
Sintawat Wangsiricharoen
Superficial CD34-positive fibroblastic tumor (SCD34FT) and PRDM10-rearranged soft tissue tumor are mesenchymal neoplasms of intermediate malignancy increasingly recognized as the same entity. They typically arise in superficial soft tissues...
Spatial transcriptomic analysis of foveolar-type gastric adenoma with raspberry-like appearance [0.03%]
具有覆盆子样外观的皱褶状胃腺瘤的空间转录组分析
Sohei Kitazawa,Eiji Takeshita,Hideomi Tomida et al.
Sohei Kitazawa et al.
Foveolar-type gastric adenoma with raspberry-like appearance (FGA-RA) is a rare subtype of Helicobacter pylori-naïve gastric neoplasm characterized by its small, reddish, polypoid morphology. This study aimed to clarify the molecular basis...
A pediatric low-grade sinonasal mesenchymal tumor harboring a novel CHD9::BEND2 fusion [0.03%]
携带新颖CHD9::BEND2融合的儿科低级别副鼻窦间叶肿瘤
Huiting Wei,Dawei Liu,Yanan Li et al.
Huiting Wei et al.
BEND2-rearranged neoplasms represent a newly emerging group of tumors with variable morphology, involving multiple tissue types and anatomical sites such as the central nervous system, bone, soft tissue, and salivary glands. Here, we descri...
Histopathologic and ancillary findings of subcentimeter thyroid nodules diagnosed as follicular neoplasms: a retrospective institutional study [0.03%]
亚厘米甲状腺结节的病理和辅助检查结果：一项机构回顾性研究
Angela Feraco,Belen Padial Urtueta,Qianqian Zhang et al.
Angela Feraco et al.
Thyroid nodules are frequently encountered, mostly detected during ultrasound evaluation of the head and neck, frequently performed for other reasons. Albeit most nodules arise in the setting of multinodular goiter, hypoechoic subcentimeter...
No increase of targetable oncogenic fusions prevalence in non-colorectal mismatch repair-deficient tumors [0.03%]
非错配修复缺陷型结直肠肿瘤的致癌融合靶点在其他肿瘤中并不富集
Loëtitia Favre,Cong-Trung Nguyen,Julien Calderaro et al.
Loëtitia Favre et al.
Mismatch repair deficiency is a well-described mechanism of carcinogenesis, which can be identified by microsatellite instability (MSI). In colorectal cancers (CRC), cases with hypermethylation of the MLH1 promoter with wild-type (WT) BRAF ...
Influence of pre-analytical factors on the success rates of smMIP and MLPA analyses in epithelial ovarian cancer [0.03%]
前期因素对上皮性卵巢癌smMIP和MLPA分析成功率的影响
L Lanjouw,M J E Mourits,G H de Bock et al.
L Lanjouw et al.
Mutation analyses are increasingly performed on tumor specimens to determine treatment eligibility and screen for genetic cancer predisposition. Sufficient tumor cell percentages and DNA concentrations are required to perform reliable mutat...