Langerhans cell sarcoma and myeloproliferative neoplasms: close or distant relatives? [0.03%]
朗格汉斯细胞肉瘤与髓系肿瘤：近亲还是远房亲戚？
Stephen E Langabeer
Stephen E Langabeer
Brett Delahunt,Hemamali Samaratunga,David Bostwick et al.
Brett Delahunt et al.
Consensus conferences in medicine are frequently conducted to formulate recommendations primarily relating to contentious areas in the diagnosis and management of disease and in the assessment of prognostic markers. While these conferences ...
Cytochrome P450 as possible link between Mallory-Denk body formation in DDC-intoxicated mouse liver and human steatohepatitis [0.03%]
Cytochrome P450可能是DDC中毒小鼠肝内Mallory-Denk小体形成和人类脂肪性肝炎之间的联系因素
Cornelia Stumptner,Karoline Fechter,Kurt Zatloukal et al.
Cornelia Stumptner et al.
Mallory-Denk bodies (MDBs) are hepatocytic inclusions in alcohol-related (ASH) and metabolic dysfunction-associated (MASH) steatohepatitis as well as in some other apparently etiologically different chronic human liver disorders. They are e...
HER2 intratumoral heterogeneity predicts response to neoadjuvant therapy in HER2-positive breast cancer: impact and interplay with HER3 expression [0.03%]
乳腺肿瘤内的HER2异质性可以预测HER2阳性型乳腺癌新辅助治疗的疗效：HER3表达的作用及相互作用
Angela Santoro,Federica Vegni,Antonio d&#x;Amati et al.
Angela Santoro et al.
Intratumoral heterogeneity (ITH) of HER2 expression and HER3 upregulation have been associated with resistance to HER2-targeted therapies. However, their predictive role in the neoadjuvant setting remains controversial. We retrospectively a...
FLCN-mutated eosinophilic renal tumors: clinicopathologic and molecular analysis of five cases highlighting morphologic heterogeneity [0.03%]
FLCN突变型嗜酸细胞肾肿瘤：五例病例的临床病理和分子分析，强调形态学异质性
Ming Zhao,Jing Song,Jiayun Xu et al.
Ming Zhao et al.
Eosinophilic/oncocytic renal cell neoplasms represent a diagnostically challenging group of tumors with overlapping morphologic and immunophenotypic features. Recent advances in molecular genetics have expanded the spectrum of FLCN-mutated ...
Multi-institutional study of mesonephric-like adenocarcinoma: its clinicopathological characteristics and histogenetic association with ectopic endometrium [0.03%]
多中心中肾样腺癌研究：临床病理特征及异位子宫内膜组织发生关系的研究
Yu Miyama,Kousuke Uranishi,Masataka Hirasaki et al.
Yu Miyama et al.
To explore the clinicopathological features and origin of mesonephric-like adenocarcinomas (MLAs), 83 cases diagnosed or suspected to be MLAs were collected from various institutions in Japan. We clearly classified 78 as MLAs (uterus: 47, o...
Differential diagnosis and predictive markers of pancreatic neuroendocrine tumours (PanNET) [0.03%]
胰腺神经内分泌肿瘤（PanNET）的鉴别诊断及预测标志物
Matthieu Tihy,Agathe Hercent,Jérôme Cros et al.
Matthieu Tihy et al.
Pancreatic neuroendocrine tumours (PanNETs) are well-differentiated neoplasms that present with a variable clinical picture and prognosis. This makes accurate classification essential for guiding treatment and assessing outcomes. The curren...
Methylated ARHGAP40 in renal cell carcinoma associated with tumor necrosis and grade: a potential biomarker for non-invasive early detection [0.03%]
肾细胞癌中与肿瘤坏死和分级相关的甲基化ARHGAP40：非侵入性早期检测的潜在生物标志物
Xiaoxia Wang,Na You,Hui Chen et al.
Xiaoxia Wang et al.
This study investigated the expression, methylation patterns, and clinicopathological implications of ARHGAP40 in renal cell carcinoma (RCC), the most common urinary malignancy. A total of 60 clear cell renal cell carcinomas (ccRCC), 30 pap...
Clinicopathological characterization of female genital tract cancers with STK11 alterations: redefining the spectrum beyond STK11 adnexal tumors [0.03%]
STK11改变的女性生殖道癌症的临床病理特征：超越STK11附属肿瘤重新定义范围
Longnv Bao,Weimao Kong,Xingzhu Pan et al.
Longnv Bao et al.
STK11 mutation is rarely reported in gynecologic malignancies. In addition to STK11 adnexal tumors, STK11 mutation can also be detected in other common types. The present study aims to investigate the clinicopathologic and prognostic featur...
Immunohistochemical expression of Ki-67, INSM1, and SSTR2A in medullary thyroid carcinoma: correlation with tumour size, vascular invasion, and biochemical outcome [0.03%]
降钙素瘤中Ki-67、INSM1和SSTR2A的免疫组化表达与肿瘤大小、血管侵犯及生化结局的相关性研究
Esther Diana Rossi,Salvatore Raia,Mariagrazia Maratta et al.
Esther Diana Rossi et al.
In the management of medullary thyroid carcinoma (MTC), current prognostic tools have limited discriminatory power, and no widely accepted tissue markers are available aside from proliferative activity and tumour necrosis, recently validate...