Temporality of change in Ki67 labelling following neoadjuvant systemic chemotherapy of breast cancer-the common drop often subsides with time [0.03%]
新辅助化疗前后乳腺癌组织标本Ki67表达变化的时间依赖性动态变化规律：常见下降多数随时间延长而反弹或缓解
Ádám Ferenczi,Tamás Lantos,Gábor Cserni
Ádám Ferenczi
Ki67 immunohistochemistry is widely used in clinical settings to assess tumour proliferation in breast cancer, yet the temporal changes in Ki67 labelling index following neoadjuvant chemotherapy (NACT) are underexplored. Matched core biopsy...
Series of renal cell carcinomas with TFE3 overexpression by copy number gains and without TFE3 gene rearrangement [0.03%]
TFE3过表达（拷贝数增加）且无TCF3基因重排的肾细胞癌系列病例研究报告
Timothy Isaac Miller,Maria Tretiakova
Timothy Isaac Miller
This case series describes four renal cell carcinomas (RCCs) with positive TFE3 protein expression by immunostain and only copy number gains detected by TFE3 fluorescence in situ hybridization without TFE3 rearrangement. Three of the four c...
CLDN18.2 expression in gastroesophageal adenocarcinoma: prevalence, heterogeneity, and prognostic implications in Spanish patients [0.03%]
西班牙患者的胃食管腺癌中CLDN18.2的表达：流行病学、异质性和预后意义
Carolina Martinez-Ciarpaglini,María Ortega,Sandra Pérez-Buira et al.
Carolina Martinez-Ciarpaglini et al.
Claudin 18 isoform 2 (CLDN18.2) has emerged as a novel therapeutical target for HER2-negative, locally advanced, or metastatic gastroesophageal adenocarcinoma. However, reported prevalence rates vary widely (24-47%), underscoring the need f...
Postmortem microbiological sampling: a prospective ESGFOR-supported study on relevance, timing, and site selection [0.03%]
尸检微生物采样：关于取样时机和部位选择的相关性、时机和位置选择的前瞻性研究
An Tamsin,Anneleen Claes,Wouter Van Den Bogaert et al.
An Tamsin et al.
Postmortem microbiological tests can help confirm infectious causes of death and identify the responsible microorganism (MO). However, challenges arise due to the lack of consensus and regulatory guidelines. This prospective single-center s...
Co-expression of PD1 and PD-L1 in the tumor cell area, by immune cells, suggests a prognostic role for overall survival in hepatocellular carcinoma [0.03%]
肝癌中肿瘤细胞区PD1和PD-L1共表达的免疫细胞提示整体存活率预后作用
Corinna M Wolf,Serenella Eppenberger-Castori,Eveline Frick-Krieger et al.
Corinna M Wolf et al.
Previous studies have shown that the programmed cell death protein 1 (PD1)/programmed cell death protein ligand 1 (PD-L1) axis regulates immune responses by modulating T-cell activity and maintaining self-tolerance, including in hepatocellu...
Clinicopathologic and molecular characterization of a series of sporadic trichoblastic neoplasms [0.03%]
一组散发性毛母细胞瘤的临床病理和分子特征分析
Carina A Dehner,Eric C Honaker,Asma K Abu-Salah et al.
Carina A Dehner et al.
Trichoblastoma (TB) is a benign primitive follicular neoplasm that can occur in the setting of Brooke-Spiegler syndrome (CYLD mutations), in association with nevus sebaceous (mosaic HRAS mutations), or sporadically. We studied the histopath...
Molecular co-alteration patterns of RICTOR-mutant metastatic lung adenocarcinomas: a single-center cohort study [0.03%]
里克TOR突变型转移性肺腺癌的分子共改变模式：一项单中心队列研究
Mehmet Berkay Ozata,Ali Aytac,Ibrahim Halil Erdogdu et al.
Mehmet Berkay Ozata et al.
RICTOR, a core component of the mTORC2 complex, regulates AKT signaling and has been implicated in tumor biology. While RICTOR amplification and overexpression have been reported, the mutational landscape of RICTOR and its molecular context...
H3.3G34W immunohistochemistry negative giant cell tumour of bone. Extended analysis of 35 such cases from a single institution in India [0.03%]
H3.3G34W阴性的骨巨细胞瘤。印度单中心35例此类患者的扩展分析
Shantveer G Uppin,Monalisa Hui,Derin Mary Thomas et al.
Shantveer G Uppin et al.
Though anti-histone H3.3G34W antibody is highly sensitive to giant cell tumours of bone, a subset of tumours which are negative on immunohistochemistry harbours variant H3F3A mutations. In this study, the diagnostic utility of anti-histone ...
Renal hemangioblastoma and renal cell carcinoma with fibromyomatous stroma and hemangioblastoma-like areas belong to the spectrum of one entity [0.03%]
肾血管球瘤和伴有纤维肌母细胞结缔组织和类似血管球瘤区域的肾细胞癌属于一种疾病的两种表现形式
Kiril Trpkov,Norel Salut,Inmaculada Ribera-Cortada et al.
Kiril Trpkov et al.
Several reports have documented renal cell carcinomas (RCC) with fibromyomatous stroma and with areas of hemangioblastoma (RCC FMS-HB). The hemangioblastoma component in RCC FMS-HB tumors was similar to the morphology of primary renal heman...
SOX11 is frequently expressed in ETV6::NTRK3-rearranged infantile fibrosarcoma and congenital mesoblastic nephroma [0.03%]
SOX11在ETS易位阳性婴儿纤维肉瘤和先天性肾母细胞瘤中的表达分析
Faizan Malik,Katelyn S Provine,Selene C Koo et al.
Faizan Malik et al.
Definitive diagnosis of infantile fibrosarcoma (IFS) and related kinase-altered spindle cell neoplasms (SCN) requires immunohistochemistry (IHC) or molecular assays that are variable in performance or not widely available. Recent transcript...