Recurrent mTOR pathway alterations in renal cell carcinoma with hemangioblastoma-like features: A multi-institutional study of 9 cases with expanding morphologic spectrum [0.03%]
伴有类红细胞增生瘤特征的肾细胞癌中mTOR通路反复出现异常：对9例具有扩展形态学谱系的病例进行多机构研究
Ming Zhao,Xiaoqun Yang,Xiaona Yin et al.
Ming Zhao et al.
Renal hemangioblastoma (HB) is a rare extra-central nervous system mesenchymal neoplasm molecularly defined by recurrent mTOR pathway alterations and lacking VHL abnormalities, distinct from its central nervous system counterpart. While rar...
Mahreen Hussain,Kseniia Malkova,Aleksandr Romanov et al.
Mahreen Hussain et al.
We report the first well-documented case of in situ follicular B-cell neoplasm (ISFN) arising in splenosis in a patient with a remote history of splenectomy. A 60-year-old man undergoing evaluation for hydrocele was incidentally found to ha...
Differentiating well-differentiated neuroendocrine tumors grade 3 from poorly differentiated neuroendocrine carcinomas and adenocarcinoma with neuroendocrine differentiation: a comprehensive review [0.03%]
welldifferentiated神经内分泌肿瘤三级与分化差的神经内分泌癌及腺癌伴神经内分泌分化鉴别的全面综述
Dorukhan Bahceci,Volkan Adsay,Olca Basturk
Dorukhan Bahceci
Gastroenteropancreatic well-differentiated neuroendocrine tumors (NETs) exhibit markedly different behavior and responses to therapy compared to poorly-differentiated neuroendocrine carcinomas (NECs). However, in certain NETs-particularly g...
Primary mucinous cystadenocarcinoma of the breast commonly harbours TP53 mutations and PI3K/AKT pathway alterations [0.03%]
原发性乳腺粘液性囊腺癌常伴有TP53突变和PI3K/AKT通路改变
Cheng Xu,Jing Wu,Ying Ding et al.
Cheng Xu et al.
Primary mucinous cystadenocarcinoma (MCA) of the breast is an invasive breast carcinoma characterized by cystic structures lined by tall columnar cells with abundant intracytoplasmic mucin, resembling pancreatobiliary or ovarian mucinous cy...
Esther Diana Rossi,Alessia Piermattei,Federica Cianfrini et al.
Esther Diana Rossi et al.
Thyroid lesions are a common finding, especially in the adult population, based on the evidence that more than 50% of individuals have thyroid nodules. The increasing detection of these lesions is mostly due to frequent ultrasonographic hea...
Neuroendocrine neoplasms of the stomach. Update on diagnostic criteria, classification, and prognostic markers [0.03%]
胃神经内分泌肿瘤的诊断标准、分类和预后标志物更新
Silvia Uccella,Stefano La Rosa
Silvia Uccella
Gastric neuroendocrine neoplasms (gNENs) encompass all the spectrum of NENs including neuroendocrine carcinomas (gNECs), mixed neuroendocrine/non-neuroendocrine neoplasms (gMiNENs) and neuroendocrine tumors (gNETs). Differently from other d...
Estrogen receptor expression by immunohistochemistry is not specific to gynecologic-type smooth muscle [0.03%]
雌激素受体的免疫组化表达不特异于妇科类型的平滑肌肿瘤
Rayan Sibira,Anna Vu,Karin Daniels et al.
Rayan Sibira et al.
Background: Criteria for malignancy in smooth muscle tumors vary by anatomic site. However, establishment of the primary site is not always possible preoperatively in the pelvis and retroperitoneum of female patients. Est...
Criteria for MDM2 fluorescence in situ hybridization testing in the diagnosis of well-differentiated adipocytic neoplasms: a retrospective utilization review of 1151 cases [0.03%]
MDM2荧光原位杂交检测在分化良好的脂肪细胞肿瘤诊断中的指征：1151例回顾性应用分析
Ashley N Flaman,Lingxin Zhang,Brendan C Dickson et al.
Ashley N Flaman et al.
Demonstration of MDM2 amplification is currently recommended to confirm the diagnosis of well-differentiated adipocytic tumors arising in the retroperitoneum, abdomen, and pelvis; recurrent "lipomas"; those with equivocal cytologic atypia; ...
Targeted molecular profiling uncovers true ceruminous adenomas with HMGA2::WIF1 and ceruminous syringocystadenoma papilliferum with BRAF V600E [0.03%]
靶向分子谱型分析发现HMGA2::WIF1真性耵聍腺瘤和BRAF V600E耵聍腺导管乳头状汗囊瘤
Lisa M Rooper,Lester D R Thompson,Ankur R Sangoi et al.
Lisa M Rooper et al.
Ceruminous adenomas are benign neoplasms that arise from ceruminous glands in the external auditory canal. While these tumors are currently regarded as a single entity, they are divided into three histologically diverse subtypes: ceruminous...
An easy and reproducible method for rapid tissue macroarray block construction [0.03%]
一种构建组织宏数组石蜡块的简便可重复方法
Sandra Lopez-Prades,Gabriela A Caballero,Iban Aldecoa et al.
Sandra Lopez-Prades et al.
Tissue macroarrays (Macro-TA), with 3-6 mm tissue cores, are an alternative to Tissue Microarrays for small case cohorts, enhanced area selection, and spatial transcriptomics. Still, Macro-TA construction methods are time-consuming and have...