Large language model-based approach for low-cost, rapid and accurate automated extraction of predictive biomarker testing results from Dutch pathology reports [0.03%]
基于大型语言模型的低成本、快速且准确地从荷兰病理报告中提取预测生物标志物检测结果的方法
Vincent D de Jager,Michiel van der Ree,Betzabel Cajiao Garcia et al.
Vincent D de Jager et al.
National cancer registries and pathology report databases contain valuable real-world information that may be used for assessment of healthcare quality or retrospective observational studies. As many of these data are currently non- or semi...
A rare case of large B-cell lymphoma with IRF4 rearrangement and concomitant 11q aberrations: a diagnostic pitfall in the molecular era [0.03%]
一项罕见的大B细胞淋巴瘤IRF4重排合并11q异常的病例报告：分子诊断时代的陷阱
Yin-Zhuan Liu,Zi-Hang Chen,Ying-Ying Zhang et al.
Yin-Zhuan Liu et al.
Over the past few decades, molecular features have become crucial in diagnosing and classifying large B-cell lymphomas (LBCLs), but overlapping features pose diagnostic challenges. We reported a 24-year-old male patient with B-cell lymphoma...
Novel HSPA8-NR4A2 rearrangement in extraskeletal myxoid chondrosarcoma: a sarcoma mimicker of neuroendocrine neoplasia [0.03%]
Extraskeletal黏液性软骨肉瘤中的新型HSPA8-NR4A2融合基因：类神经内分泌肿瘤的 sarcoma
Sabina Barresi,Roberto Passa,Silvia Vallese et al.
Sabina Barresi et al.
Extraskeletal myxoid chondrosarcoma (EMC) is a rare mesenchymal neoplasm of uncertain differentiation associating with diagnostic NR4A3 gene rearrangements. An unusual case of EMC harboring the novel HSPA8::NR4A2 gene fusion and neuroendocr...
Correction to: Integrative diagnostic approach to salivary gland tumors: from clinical evaluation to molecularly targeted therapy [0.03%]
唾液腺肿瘤诊断的整合方法（临床评估到分子靶向治疗）的更正
Anna Luíza Damaceno Araújo,Reydson Alcides de Lima-Souza,Fernanda Viviane Mariano et al.
Anna Luíza Damaceno Araújo et al.
FigATree: a novel framework for histological subtyping and grading of lung adenocarcinoma [0.03%]
figatree：一种用于肺癌腺癌组织分型和分级的新型框架
Qiang Huang,Jiajun Zhang,Qiming He et al.
Qiang Huang et al.
Lung adenocarcinoma (LUAD) exhibits pronounced morphological heterogeneity, making accurate subtyping and grading a persistent challenge in pathology. Conventional deep learning methods often lack the granularity and interpretability requir...
Efficient finetuning of foundation model combined with few-shot learning improves pattern recognition in histopathology [0.03%]
结合少量学习的高效基础模型微调改善了组织病理学中的模式识别效果
Ayk Jessen,Christoph Blattgerste,Maximilian Legnar et al.
Ayk Jessen et al.
Neural networks have achieved state-of-the-art performance in classifying whole slide image (WSI) patches in histopathology through supervised learning. However, their reliance on large-scale annotated datasets imposes a substantial labelin...
MTOR-mutated eosinophilic renal cell carcinomas with loss of chromosome 1 and high metastatic potential: further expanding the spectrum of TSC/mTOR pathway mutated renal tumors [0.03%]
MTOR突变型伴第1号染色体丢失及高转移潜能的嗜酸细胞肾癌：进一步丰富TSC/MTOR通路突变型肾肿瘤的类型
Jung Woo Kwon,Melissa Y Tjota,Tatjana Antic
Jung Woo Kwon
TSC/mTOR pathway alteration is recurrent in numerous renal tumor types, such as eosinophilic vacuolated tumor (EVT), low-grade oncocytic tumor of the kidney (LOT), and eosinophilic solid and cystic (ESC) renal cell carcinoma (RCC). Recently...
Histological and biomarker landscape of Claudin18.2-positive gastric and gastroesophageal junction cancers: a study of 937 cases [0.03%]
Claudin18.2阳性胃和胃食管交界处癌的组织病理学和生物标志物谱特征（937例研究）
Qingxia Zhang,Xinya Zhao,Xiaozheng Huang et al.
Qingxia Zhang et al.
Although Claudin18.2 (CLDN18.2) is a promising therapeutic target in gastric and gastroesophageal junction cancer (G/GEJ), its expression profile based on histological subtypes remains unclear. This study aimed to investigate CLDN18.2 expre...
The shifting paradigm of programmed cell death ligand 1 (PD-L1) in anaplastic thyroid carcinoma: from pathology to clinical practice [0.03%]
程序性死亡配体1(PD-L1)在未分化甲状腺癌中的研究进展及临床应用展望：从病理到实践
Vincenzo Fiorentino,Mariagiovanna Ballato,Ludovica Pepe et al.
Vincenzo Fiorentino et al.
Anaplastic thyroid carcinoma (ATC) represents one of the most aggressive human malignancies, characterized by rapid progression, early metastasis, and dismal prognosis. The emergence of immune checkpoint blockade targeting the PD-1/PD-L1 ax...
Combined neuroendocrine tumor and goblet cell adenocarcinoma of the appendix: a distinct entity? Insights from three new cases [0.03%]
阑尾神经内分泌肿瘤和杯状细胞腺癌合并发生：三个新病例的启示
Laurent Doucet,Stéphanie Patouraux,Mohamed-Amine Bani et al.
Laurent Doucet et al.
We report three new cases of combined neuroendocrine tumor-goblet cell adenocarcinoma of the appendix, submitted over a 15-year period to the French expert pathological network TENPath, in order to provide additional information about this ...