Diffuse hemispheric glioma, H3 G34-mutant, a single centre experience and histopathological analysis [0.03%]
弥漫性半球胶质瘤H3 K27M突变型的单中心临床及病理分析
Faizan Amer,Usman Hassan,Sajid Mushtaq et al.
Faizan Amer et al.
Diffuse hemispheric glioma, H3 G34-mutant, is a rare, recently categorized, high-grade, infiltrative glioma. It usually occurs in the cerebral hemispheres of adolescents and young adults. Mutations in the H3-3A gene play a key oncogenic rol...
Myeloperoxidase-positive mononuclear cells predominate over CD3-positive T-lymphocytes in the epidermis of Stevens-Johnson syndrome and toxic epidermal necrolysis [0.03%]
Stevens-Johnson综合征和中毒性表皮坏死松解症中，髓过氧化物酶阳性单核细胞占表皮浸润细胞的多数而CD3阳性T淋巴细胞较少见
Masakazu Fujimoto,Yuki Teramoto,Kai Mizoguchi et al.
Masakazu Fujimoto et al.
Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are life-threatening mucocutaneous conditions traditionally regarded as severe T cell-mediated hypersensitivity reactions. However, recent evidence has highlighted the potent...
Giulia Vocino Trucco,Eleonora Duregon,Mauro Papotti et al.
Giulia Vocino Trucco et al.
The 5th edition of the WHO classification of endocrine and neuroendocrine tumors represents a significant advancement in the diagnostic approach to adrenocortical carcinoma (ACC), integrating novel molecular insights with established histop...
AI assessment of tumor-infiltrating lymphocytes on routine H&E-slides as a predictor of response to neoadjuvant therapy in breast cancer-a real-world study [0.03%]
基于常规H&E切片的AI评估肿瘤浸润淋巴细胞预测乳腺癌新辅助治疗反应的真实世界研究
Dusan Rasic,Elisabeth Ida Specht Stovgaard,Anne Marie Bak Jylling et al.
Dusan Rasic et al.
Tumor-infiltrating lymphocytes (TILs) are a predictive and prognostic biomarker in triple-negative (TNBC) and HER2 + breast cancer (BC). This study applies artificial intelligence (AI) to evaluate their value in a multi-institutional cohort...
Superficially located CIC::DUX4-rearranged sarcomas in children: insights from a long-term survival case series [0.03%]
儿童CIC::DUX4重排肉瘤的临床特征及长期生存队列研究新见解
Gina Del Vecchio,Rita Alaggio,Alessandra Stracuzzi et al.
Gina Del Vecchio et al.
Soft tissue sarcomas account for approximately 10% of all cancers in the pediatric population, with undifferentiated round cell sarcomas-historically referred to as Ewing-like sarcomas-forming a notable subset. Recent molecular profiling ha...
Perivascular epithelioid cell tumors of the urinary bladder: a multi-institutional clinicopathologic and molecular analysis of 21 cases [0.03%]
泌尿膀胱上皮样细胞血管肿瘤的临床病理和分子分析（21例多中心研究）
Ankur R Sangoi,Anandi Lobo,Ankit Tiwari et al.
Ankur R Sangoi et al.
While perivascular epithelioid cell tumor (PEComas) have been described in most organ systems, only a few bladder PEComas have been reported. Although most behave in an indolent fashion, a subset may develop metastasis. Herein, we describe ...
Thomas Ritz,Jovan Tanevski,Jana Baues et al.
Thomas Ritz et al.
Hepatocellular carcinoma (HCC) has a poor prognosis. While molecular profiling has identified subclasses with potentially druggable pathways, implementation in routine diagnostics remains challenging. Although immunohistology may aid HCC cl...
ERBB2/ERBB3‑mutated S100/SOX10‑positive high‑grade uterine sarcoma-a case report on a rare entity [0.03%]
ERBB2/ERBB3基因突变、S100/SOX10阳性高度恶性的子宫肉瘤一例报告
Xingming Huang,Ying He,Wei Wang
Xingming Huang
ERBB2/ERBB3‑mutated S100/SOX10‑positive uterine sarcoma is a recently described entity with distinct morphological, immunophenotypic, and molecular features, representing a subset of high-grade uterine sarcomas. This tumor is characterize...
Biphasic (squamoid) papillary renal cell carcinoma: a distinct molecular and morphologic subtype within the PRCC spectrum [0.03%]
双相（鳞状）乳头状肾细胞癌：PRCC谱系中的一个独特的分子和形态亚型
Zhichun Lu,Yan Zhou,Wei Fan et al.
Zhichun Lu et al.
Biphasic (squamoid) papillary renal cell carcinoma (BPRCC) is a recently recognized and rare variant of renal cell carcinoma, defined by biphasic morphology and distinct immunophenotypic features. Previously considered a subtype of classic ...
PTEN hamartoma of soft tissue (PHOST) and fibroadipose vascular anomaly (FAVA): a comparative clinicopathologic and molecular analysis [0.03%]
PTEN软组织硬化病（PHOST）与纤维脂肪血管异常（FAVA）的临床病理及分子比较分析
Shuang Xue,Fangfang Fu,Ying Wang et al.
Shuang Xue et al.
PTEN hamartoma of soft tissue (PHOST) is a rare entity within the PTEN-related hamartoma tumor syndrome spectrum. It often presents with overlapping clinical features with other vascular anomalies, such as fibroadipose vascular anomaly (FAV...