History of episodic heavy alcohol use predicts antidepressant effectiveness of ketamine [0.03%]
既往有重度饮酒史可预测氯胺酮抗抑郁疗效
Aaishah R Raquib,Vy Nguyen,Joshua C Brown et al.
Aaishah R Raquib et al.
Rationale: Antidepressant response to ketamine is greatest in patients with a family history of alcohol use disorder (AUD), but it remains unclear if this trend holds true for a personal history of alcohol use. ...
Adolescent onset of volitional ethanol intake normalizes sex differences observed with adult-onset ethanol intake and negative affective behaviors during protracted forced abstinence [0.03%]
青春期自发摄入乙醇可使成年期摄入乙醇引起的压力相关行为正常化
Caitlyn M Edwards,Zishuo Xu,Danny G Winder
Caitlyn M Edwards
Rationale: Negative affect during ethanol abstinence can lead to relapse and dependence. Voluntary ethanol drinking models are crucial for examining negative affect following chronic ethanol access, but female rodents oft...
The effect of methamphetamine and 3,4-methylenedioxymethamphetamine on peripheral endocannabinoid concentrations: a study in healthy adults [0.03%]
甲基苯丙胺和3,4-亚甲二氧基甲基苯丙胺对外周内源性大麻素浓度的影响：一项健康成人研究
Ana Deutsch,Connor J Haggarty,Gavin N Petrie et al.
Ana Deutsch et al.
Rationale: Stimulant drugs such as methamphetamine (MA) and 3,4-methylenedioxymethamphetamine (MDMA) can impact neurobiological systems implicated in stress, reward processing, and drug use. Although recent preclinical ev...
The effects of low-dose ketamine and (2R,6R)-Hydroxynorketamine on affective behaviors associated with protracted oxycodone withdrawal [0.03%]
低剂量氯胺酮和(2R,6R)-羟基诺氯胺酮对长期氧可酮脱毒后情感行为的影响
Michael J Lehane,Gregory C Sartor
Michael J Lehane
Rationale: In subjects with opioid use disorder (OUD), affective symptoms persist long after opioid cessation and contribute to poor treatment outcomes. (2R,6R)-Hydroxynorketamine (HNK), a ketamine metabolite, has emerged...
Targeting synaptic plasticity and acetylcholine dysregulation in the medial prefrontal cortex: Rosmarinic acid attenuates Autism-like phenotypes in Shank3B-/- mice via the CREB/BDNF pathway [0.03%]
针对外侧杏仁核胆碱能神经元的光遗传学激活改善阿尔茨海默病模型小鼠的空间工作记忆及相关病理生理变化
Jiahui Shi,Mei Chen,Yushu Zhang et al.
Jiahui Shi et al.
Rationale: Autism spectrum disorder (ASD) is characterized by cognitive deficits, repetitive behaviors, and social impairments. The SH3 and multiple ankyrin repeat domains protein 3B-deficient (Shank3B-/-) mouse model dis...
Effects of MMP8 inhibitors on chronic unpredictable mild stress-induced neuroinflammation and depressive-like behavior：exploring the underlying molecular mechanisms [0.03%]
MMP8抑制剂对慢性轻度不可预测应激诱导的神经炎症和抑郁样行为的影响及其潜在机制研究
Yan Ren,Weikang Chen,Jinhui Wang et al.
Yan Ren et al.
Objective: Studies have demonstrated a close association between alterations in the immune system and major depressive disorder (MDD), with MDD potentially inducing neuroinflammation, hippocampal atrophy, and depression-l...
Joshua L Gowin,Vanessa Stallsmith,Katelyn Weldon et al.
Joshua L Gowin et al.
Rationale: Widespread legalization of cannabis in the US in recent years has coincided with increasing use of alcohol and cannabis at the same time. Cannabis is thought to confer synergistic effects on alcohol intoxicatio...
Acetylcholine nicotinic receptors play a central role in the modulation of rewarding behaviors by interacting with dopamine transmission: evidence from male rat sexual behavior [0.03%]
乙酰胆碱烟碱型受体通过与多巴胺传递相互作用在调节雄性大鼠性行为的快感行为中发挥核心作用：证据来自雄性大鼠性行为研究
Ana Evelia Hernández-Colín,Ana Canseco-Alba,Gabriela Rodríguez-Manzo
Ana Evelia Hernández-Colín
Rationale: Nicotinic acetylcholine receptors (nACh) are involved in the regulation of dopamine (DA) transmission at the mesolimbic (MSL) system, which regulates naturally rewarding behaviors like sexual behavior. Acetylch...
Mu or delta opioid receptor antagonists increase the expression of social conditioned place preference in early adolescent mice [0.03%]
μ或δ型阿片受体拮抗剂可增加早期青春期小鼠的社会条件性位置偏爱行为表达
Zofia Harda,Marta Klimczak,Klaudia Misiołek et al.
Zofia Harda et al.
Rationale: Social behaviors undergo dramatic changes during adolescence, enabling the development of adult social abilities. These changes are intricately linked to the development of the brain reward system and the activ...
Bing Dai,Dayu Lin
Bing Dai
Rationale: Aggression is an innate social behavior prevalent across animal species. However, in modern human society, inter-personal aggression is considered disruptive and detrimental to both families and communities. Cl...