Spike-wave discharges are uncoupled with cognitive outcome in aged Long-Evans rats [0.03%]
棘波放电与老化Long-Evans大鼠认知结果无关
Craig Myrum,Zach Uttke,Diba Ramezan et al.
Craig Myrum et al.
Rational: Rodent EEGs display 7-12 Hz oscillations called spike-wave discharges (SWDs) that are more abundant with age, and some data suggest that they might interfere with hippocampus-dependent memory processing. ...
The nitric oxide synthase inhibitor 7-nitroindazole attenuates social withdrawal and memory impairments induced by Blockade of the NMDA receptor in the rat [0.03%]
NMDA受体阻断引起的社交退缩和记忆缺损由NO合成酶抑制剂7-硝基异吲哚唑缓解
Angeliki Metaxia Styla,Elias Begas,Nikolaos Pitsikas
Angeliki Metaxia Styla
Rationale: That exaggerated production of the gaseous molecule nitric oxide (NO) is associated with the pathogenesis of schizophrenia is well-documented. Therefore, compounds that can adjust nitrergic activity such as NO ...
Chronic delivery of buprenorphine during abstinence decreases incubation of heroin seeking and neuronal activation in medial prefrontal cortex and striatum in male and female rats [0.03%]
长效缓释布洛芬鼻喷雾剂减少雄性和雌性大鼠海洛因觅药行为及海马神经元激活作用
Jennifer M Bossert,Kiera E Caldwell,Hannah Bonbrest et al.
Jennifer M Bossert et al.
Rationale and objective: Buprenorphine is an FDA-approved medication for opioid addiction, but the brain regions underlying its therapeutic effects remain unknown. We previously found that chronic buprenorphine treatment ...
Development of the Yale pain stress test to elicit a multi-level stress response and assess stress adaptability [0.03%]
耶鲁大学疼痛压力测试的发展：诱发多水平应激反应并评估应激适应能力
Nia Fogelman,Shaina Barreto,Colleen McGowan et al.
Nia Fogelman et al.
Rationale: High levels of stress and acute stress responses are significant predictors of chronic illnesses; however, specific stress response components of resilience and healthy coping are not well understood. ...
Effect of dietary stimulation on acute changes in GLP-1, alcohol responses, craving, and attentional bias: a randomized, placebo-controlled laboratory study [0.03%]
饮食刺激对GLP-1、酒精反应、渴求和注意力偏差的急性影响：一项随机对照实验室研究
Michael P Bremmer,Jimikaye B Courtney,Andrew P Neilson et al.
Michael P Bremmer et al.
Rationale: Preclinical and clinical findings support the potential for GLP-1 receptor activation to reduce alcohol consumption and reward. Human experimental studies are needed to clarify whether acute changes in endogeno...
Adolescent binge drinking causes sex-specific deficits in behavioral reactivity, endocrine recovery from stress and altered expression of hypothalamic KCC2 in males [0.03%]
青春期狂饮导致男性行为反应缺陷、应激后内分泌恢复障碍以及下丘脑KCC2表达改变的性别差异
Bilge Büyükdemirtaş,Milan Benn,Han Bin Kwon et al.
Bilge Büyükdemirtaş et al.
Rationale: Binge drinking during adolescence is associated with a higher risk of developing Alcohol Use Disorders and impaired stress reactivity in adulthood. The hypothalamic-pituitary-adrenal axis matures during adolesc...
Tobacco deprivation impairs metacognitive accuracy and cognitive flexibility [0.03%]
烟草剥夺损害元认知准确性和认知灵活性
Alexander Soutschek,Tina Engelmann,Rebekka S Mattes et al.
Alexander Soutschek et al.
Rationale: Tobacco dependence is characterized by a high relapse rate. It is thus important to obtain a better understanding of the cognitive precipitants of smoking relapses, and how these are changed under tobacco depri...
7,8-Dihydroxyflavone ameliorates bone loss by regulating TRKB/AKT/FOXO3a pathway in a mouse model of alzheimer's disease [0.03%]
7,8-二羟基黄酮通过调节TRKB/AKT/FOXO3a信号通路改善阿尔茨海默病小鼠骨量减少情况
Dong Liu,Xiaoxiong Li,Peng Shi et al.
Dong Liu et al.
Background: The incidence of osteoporosis is increased in Alzheimer's disease (AD). The pathogenesis of AD with osteoporosis is still unknown, there is no ideal treatment as yet for it. 7,8-Dihydroxyflavone (7,8-DHF), a f...
Assessing behavioural economic demand for morphine after an acute dose in individuals with- and without childhood trauma: a double-blind, randomised, controlled trial [0.03%]
行为经济学角度下吗啡的药物需求定量评估：在患有和未患童年创伤的人群中使用吗啡后的用药意愿双盲随机对照试验
Martin Trøstheim,Benjamin L Berey,Elizabeth R Aston et al.
Martin Trøstheim et al.
Background: Childhood trauma is associated with positive subjective responses to acute opioids in the laboratory. Yet, its impact on behavioural economic demand for opioids remains unclear. Because demand can predict futu...
Individual and additive effects of childhood maltreatment and substance use disorder histories on baseline and stress-induced changes in peripheral stress biomarkers [0.03%]
童年虐待史和物质使用障碍病史对基线以及应激诱导的外周应激生物学标志物变化的个体及累加作用
Abigail R Lunge,Lars Östman,Ryann Tansey et al.
Abigail R Lunge et al.
Background: Exposure to childhood maltreatment (CM) has serious consequences on the health of affected individuals, potentially elevating vulnerability to various psychopathologies, including substance use disorders (SUDs...