Long- term administration of low doses of psilocybin causes epigenetic changes in the rat medial prefrontal cortex [0.03%]
长期低剂量给药裸盖菇素可引起大鼠前额叶皮层的表观遗传学变化
Agnieszka Wawrzczak-Bargieła,Małgorzata Jelonek-Kozioł,Weronika Kumorek et al.
Agnieszka Wawrzczak-Bargieła et al.
Rationale: Psilocybin (PSI) microdosing, defined as a repeated administration of sub-perceptual doses, has gained increasing attention as a potential therapeutic strategy for affective and anxiety disorders. However, some...
Variation in cocaine responses across genetically diverse mouse strains [0.03%]
遗传多样化的近交系小鼠对可卡因反应的差异性研究
Malia Pollock,AbdulRahman Abbas,Hien M Bui et al.
Malia Pollock et al.
Rationale: Repeated exposure to psychostimulants can be followed by negative affective mood states when the drug is no longer present. These states can function as powerful negative reinforcers, intensifying drug cravings...
Severity-dependent changes in hippocampal necroptosis markers and neuronal loss in a PTSD-like mouse model: potential involvement of nitric oxide signaling [0.03%]
基于类似PTSD的小鼠模型探讨不同严重程度下海马区坏死性凋亡标志物及神经元损失的变化及相关NO信号通路的潜在作用机制研究
Alireza Barati,Ramin Khaghani,Amir Ahmad Salarian et al.
Alireza Barati et al.
Background: Post-traumatic stress disorder (PTSD) is a psychiatric condition triggered by traumatic events and associated with long-lasting neurobiological alterations, particularly in the hippocampus. Although hippocampa...
Association between aperiodic activity and impulsivity in individuals with methamphetamine use disorder [0.03%]
甲氨蝶呤使用障碍患者的非周期性脑电活动与冲动控制之间的关系研究
Yun Zhao,Jing Li,Jie Zhang et al.
Yun Zhao et al.
Rationale: Methamphetamine use disorder (MUD) poses significant public health risks, with individuals often exhibiting heightened impulsivity. Traditional electroencephalography (EEG) spectral analyses have yielded incons...
Richard Saville-Smith,Sharday Mosurinjohn
Richard Saville-Smith
Purpose: This paper critiques the use of the term "mysticism" in psychedelic research, arguing its continued use is outdated and misleading. Findings: ...
Interrogating roles for VTA dopamine neurons in locomotion and ultrasonic vocalizations elicited by different classes of rewarding drugs [0.03%]
探究不同种类的奖励药物诱发中脑腹侧被盖区多巴胺神经元在运动和超声叫声中的作用机制
Kate A Lawson,Stephen V Mahler
Kate A Lawson
Rationale: In humans, researchers can readily query the subjective states elicited by drugs of abuse, but no such introspective readout is currently available in rodents. ...
Early life nicotine vapor exposure increases nicotine vapor seeking in adult male rats [0.03%]
生命早期接触尼古丁气溶胶可增加成年大鼠的尼古丁气溶胶觅食行为
Liliana Maynez-Anchondo,Olga Rohrer,Miguel Urbina et al.
Liliana Maynez-Anchondo et al.
Rationale: The ongoing epidemic of nicotine vaping use in adolescents and young adults presents a significant health concern, yet the long-term effects of nicotine vaping remain largely unknown. ...
The use of THC cutoff levels in blood and oral fluid for detecting impairment in frequent cannabis users who smoked cannabis the "evening before" [0.03%]
大麻频繁使用者在“前一天晚上”使用大麻后的血液和口腔液体中THC截断值的运用以检测其能力受损情况
Sampson Zhao,Alex Battistuzzi,Christina Zakala et al.
Sampson Zhao et al.
Rationale: Some jurisdictions use blood delta-9-tetrahydrocannabinol (THC) thresholds of 2ng/mL and oral fluid THC thresholds of 25ng/mL for detection of impaired driving. ...
Combined DMT-harmine formulation reduces negative self-referential emotions during social self-evaluation: a randomized placebo-controlled trial in healthy volunteers [0.03%]
含DMT和 harmine 复合制剂可降低健康志愿者社会评价过程中的负面自我参照情绪：一项安慰剂对照试验
Helena D Aicher,Joëlle Dornbierer,Luzia Caflisch et al.
Helena D Aicher et al.
Rationale and objectives: Negative self-referential emotions such as embarrassment and shame play a key role in the psychopathology of psychiatric disorders but are often insufficiently addressed by standard treatments. P...
Dose-effect analysis of 6-APB ("Benzofury") on fear memory, motor behavior, and reward [0.03%]
6-APB（"Benzofury"）对恐惧记忆、运动行为和奖赏的剂量效应分析
Kyla M Whitelock,Kaitlin R Van Alstyne,Liam J Conaboy et al.
Kyla M Whitelock et al.
Rationale: 6-(2-aminopropyl)benzofuran (6-APB) is a recreational drug that is structurally similar to MDMA. Very little is known about the behavioral effects of 6-APB or its dose-effect relationship in vivo. As the popula...