The efficacy and safety of trazodone for sleep problems in depressive patients: a GRADE-assessed systematic review and meta-analysis of clinical trials [0.03%]
系统综述与meta分析：抑郁患者的曲唑酮治疗睡眠问题的有效性和安全性及分级评估
Almuthana K Hameed,Mohammed Asiri,Muzdalifa Mejbel Fedwi et al.
Almuthana K Hameed et al.
Objective: This systematic review and meta-analysis evaluated the efficacy and safety of trazodone for managing sleep disturbances in patients with depression, addressing its dual role in improving sleep quality and depre...
Coadministration of scopolamine and mGlu2 NAM VU6001966 as a novel antidepressant approach: Lowering effective dose and reducing cognitive side effects [0.03%]
新型抗抑郁方法：东莨菪碱和mGlu2负向别构变构剂VU6001966合用降低有效剂量并减少认知副作用
Yana Babii,Agnieszka Pałucha-Poniewiera,Bartosz Bobula et al.
Yana Babii et al.
Rationale: Scopolamine, whose rapid and sustained antidepressant effects were first described nearly two decades ago, is associated with significant adverse effects that limit its clinical use. A safer alternative may inv...
Effects of N-acetylcysteine treatment on frontal glutamate and GABA levels and associations with drinking quantity in people with co-occurring posttraumatic stress disorder and alcohol use disorder [0.03%]
N-乙酰半胱氨酸治疗对共病创伤后应激障碍和酒精使用障碍患者的额叶谷氨酸和γ-氨基丁酸水平及其与饮酒量的关系的影响
James J Prisciandaro,Amber M Jarnecke,Jane E Joseph et al.
James J Prisciandaro et al.
Rationale: Though half of people with posttraumatic stress disorder (PTSD) develop alcohol use disorder (AUD), co-occurring PTSD and AUD (PTSD + AUD) is associated with more severe clinical outcomes relative to either alo...
Integrating genome-wide and epigenome-wide associations for antipsychotic induced extrapyramidal side effects [0.03%]
精神药物引起锥体外系不良反应的全基因组和表观基因组关联整合分析
Kai Yao,Johan H Thygesen,Siobhan K Lock et al.
Kai Yao et al.
Rationale: Antipsychotic medications are the first-line treatment for schizophrenia. Around 40% of people who are treated with antipsychotics could develop extrapyramidal side-effects (EPSE) including: (1) Dyskinesia, (2)...
Electroconvulsive therapy (ECT) increases serum hypoxia‑inducible factor‑1 alpha (HIF- 1α) in depressed patients [0.03%]
电休克治疗增加抑郁症患者血清缺氧诱导因子-1α(HIF-1α)水平
Esra Aslan,Bahadır Demir,Hasan Ulusal
Esra Aslan
Objective: Hypoxia has been shown to cause disturbances in neurohormonal regulation in the brain and may play an important role in the pathophysiology of depression. Hence, this study aimed to evaluate the relationship be...
Daily self-assessment within a regimen of microdosing indicates enhanced psychological functioning on microdosing days relative to non-microdosing days [0.03%]
每日自我评估表明，在微剂量用药的日子里的心理功能比非用药日更佳
Michelle St Pierre,Elena Argento,Jordyn Cates et al.
Michelle St Pierre et al.
Rationale: Repeated self-administration of small doses of psychedelics, known as microdosing, has been associated with perceived improvements in psychological functioning. However, few studies have examined effects at the...
Mitochondrial dysfunction in PTSD: A mechanism to understand trauma susceptibility? [0.03%]
线粒体功能障碍与创伤后应激障碍：理解创伤易感性的机制？
Felippe E Amorim,Charlotte S Rye,Amy L Milton
Felippe E Amorim
Rationale and objectives: Post-Traumatic Stress Disorder (PTSD) is a complex mental health condition that arises following exposure to traumatic events. Converging evidence suggests mitochondrial dysfunction and brain ene...
Voluntary wheel running prevented the short-term behavioural effects of vicarious intermittent social defeat in female mice [0.03%]
自愿主动轮运动可以防止雌性小鼠经历间接社交挫败后的短期行为影响
María Ángeles Martínez-Caballero,Claudia Calpe-López,María Pilar García-Pardo et al.
María Ángeles Martínez-Caballero et al.
In a previous study, we observed that a Vicarious Intermittent Social Defeat (VISD) protocol induced anxiety- and depression-like symptoms in late adolescent female mice, and in some of them, enhanced sensitivity to cocaine reward in adulth...
Examining the impact of adolescent social isolation on oxycodone sensitization [0.03%]
青少年社会孤立对羟考酮敏感性影响的分析研究
Erin A English,Lisa A Briand
Erin A English
Rationale: Chronic stress and social isolation during adolescence can disrupt normal development and increase substance use behaviors in adulthood. Object...
A naturalistic examination of the effects of chronic and acute cannabis use on cognition and perceived symptoms of attention-deficit/hyperactivity disorder [0.03%]
慢性及急性大麻使用对认知及注意力不足过动症症状影响的自然主义考察
Amanda M Stueber,Emily M LaFrance,Robyn S Herbert et al.
Amanda M Stueber et al.
Rationale: People with attention-deficit/hyperactivity disorder (ADHD) are more likely to use cannabis. However, the effects of chronic and acute cannabis use on people with ADHD remain unclear. ...