A randomised, double-blind, placebo-controlled trial examining the dose-dependent effects of acute alcohol intoxication on neurocognitive performance [0.03%]
酒精急性中毒对神经认知功能影响的随机双盲对照试验
Blair Aitken,Brook Shiferaw,Luke A Downey et al.
Blair Aitken et al.
Rationale: Acute alcohol intoxication impairs cognitive and motor control, elevating risk in safety-critical contexts. While blood alcohol concentration (BAC) quantifies exposure, it does not reflect real-time functional ...
Corticosteroid-Induced neuropsychiatric manifestations: From pathophysiology to management [0.03%]
糖皮质激素所致神经精神系统障碍：从发病机制到处理方法
Adil Husain,Firoz Ahmad
Adil Husain
Corticosteroids are among the most widely prescribed medications in modern medicine, valued for their potent anti-inflammatory and immunosuppressive properties. Despite their therapeutic benefits, corticosteroids are frequently associated w...
Early life adversity, oxytocin system alterations, and addiction vulnerability: a narrative review [0.03%]
早期逆境、催产素系统改变与成瘾易感性的关系：综述
Ehsan Saboory,Samaneh Ahmadian-Moghadam,Nasrin Mehranfard
Ehsan Saboory
Prenatal and early-life stress (ELS) reprogram the hypothalamic-pituitary-adrenal (HPA) axis and intersecting neurotransmitter circuits, producing long-lasting alterations in the oxytocin (OXT) system. Accumulating clinical and pre-clinical...
Involvement of the dorsal raphe serotonin system in basal and punished heroin self-administration and stress-induced reinstatement in male and female rats [0.03%]
腹中缝脑干5-羟色胺系统在基础和受惩罚的海洛因自助行为以及应激诱导复吸中的作用：雌雄鼠的结果分析
Claire Deckers,Doretta McCully,Joseph Meissler et al.
Claire Deckers et al.
Rationale: Opioid use disorders are marked by both drug use despite negative consequences and drug use to avoid negative physiological and psychological states. The dorsal raphe nucleus (DRN) serotonin (5-HT) system modul...
Influences of subtle NMDA receptor blockade and allosteric modulation of α5 GABAA receptors on reward-related impulsivity in rats [0.03%]
N-甲基-D天冬氨酸受体轻度阻断和α5型γ-氨基丁酸受体变构调节对大鼠奖赏相关冲动行为的影响
Jovana Aranđelović,Bojan Batinić,Dishary Sharmin et al.
Jovana Aranđelović et al.
Rationale: Available data suggest that α5GABAA receptors play an important role in the regulation of impulsive behavior. Objectives: W...
How does cognition change over time in young people who use cannabis recreationally? A narrative review of the longitudinal literature to date [0.03%]
娱乐性使用大麻对年轻人认知功能的纵向影响：文献综述
Gabrielle Abbott,Lisa-Marie Greenwood,Jessica G Bartschi et al.
Gabrielle Abbott et al.
Introduction: The regular consumption of cannabis has been associated with changes in cognition. However it is unclear how cognitive performance changes over time with continued cannabis use and whether cognitive alterati...
Neuroimaging as the 'missing link' for preclinical to clinical translation: an example using N-acetylcysteine among individuals with cocaine- and opioid-use disorders receiving methadone treatment [0.03%]
神经影像作为从临床前到临床转化的“缺失环节”：以美沙酮维持治疗中可卡因和阿片类使用障碍患者的N-乙酰半胱氨酸为例
Spencer Birney,Annie Cheng,Theresa Babuscio et al.
Spencer Birney et al.
Rationale: Cocaine use disorder (CUD) remains a major public health problem, particularly among individuals receiving medications for opioid use disorder (mOUD), where ongoing cocaine use is associated with poorer treatme...
A mindfulness-based intervention to reduce altered brain reward function in cannabis use disorder: a double-blind, active and passive, randomised controlled fMRI trial [0.03%]
基于正念干预减少大麻使用障碍患者异常奖赏功能的脑机制研究：一项双盲随机对照fMRI试验
Emillie Beyer,Martine Skumlien,Govinda Poudel et al.
Emillie Beyer et al.
Cannabis Use Disorder (CUD) affects ~ 50 million individuals worldwide and is associated with alterations in brain reward pathways. Mindfulness-based interventions (MBIs) show promise in reducing substance use and aberrant brain function in...
Study on the improvement effect and mechanism of resveratrol on cognitive impairment in tau mutant adenovirus-induced alzheimer's disease model mice [0.03%]
白藜芦醇对tau突变腺病毒诱发阿尔茨海默病模型小鼠认知障碍的改善作用及机制研究
Shuting Chen,Kexuan Zhao,Zhidan Shi et al.
Shuting Chen et al.
Rationale: Tau protein hyperphosphorylation and neuroinflammation playimportant roles in the onset and progression of Alzheimer's disease (AD). SIRT1has been implicated in the regulation of synaptic plasticity, cognitive ...
Pharmacological effect of (±)-trans-3-methylfentanyl and (±)-cis-3-methylfentanyl [0.03%]
(±)-反式-3-甲基芬太尼和(±)-顺式-3-甲基芬太尼的药效学作用研究
Yuanyuan Chen,Miaojun Lai,Wenjie Qiao et al.
Yuanyuan Chen et al.
Rational: (±)-trans-3-methylfentanyl and (±)-cis-3-methylfentanyl are stereoisomeric analogues of 3-methylfentanyl. Although both exhibit high potency as µ-opioid receptor (MOR) agonists, their pharmacological profiles...