Effects of TPA023B, an α2/3/5GABAA subtype-selective partial allosteric modulator, on fentanyl-induced respiratory depression in male rats: comparison with the non-selective benzodiazepine midazolam [0.03%]
TPA023B，一种α2/3/5GABAa亚型部分变构调节剂，对雄性大鼠喷他佐辛诱导的呼吸抑制的影响：与非选择性苯二氮卓类药物咪达唑仑的比较
Loc M Pham,Andria B Nanney,Jordan Hasting et al.
Loc M Pham et al.
Rationale: Opioid-related overdose deaths involving benzodiazepines have increased in recent years, and prior studies have reported that clinically used benzodiazepines can enhance the respiratory-depressant effects of mu...
Decoding the bidirectional links between alcohol misuse and aggression: toward a unified translational framework [0.03%]
酒精滥用和攻击行为的双向联系及其统一的转化模型
Nicholas M Russell,Micah D Frier,Marco Bortolato et al.
Nicholas M Russell et al.
Rationale: The relationship between alcohol misuse and aggression has long intrigued clinical and preclinical researchers. While acute alcohol use is well known to promote aggression, converging evidence indicates a more ...
Ayahuasca prevents the reinstatement of cocaine-induced rewarding effects in C57Bl/6 mice [0.03%]
胡椒素防止胡椒素诱导的条件性位置偏爱在C57Bl/6小鼠中的复燃效应
Vítor Bruno,Lídia Emmanuela Wiazowski Spelta,Matheus Lujan Pereira et al.
Vítor Bruno et al.
Rationale: Ayahuasca is a brew containing the psychedelic compound N,N-dimethyltryptamine (DMT) and β-carbolines, traditionally consumed in indigenous rituals. Recent studies suggest its potential to reduce depression an...
Personality profiles and trauma history in ketamine therapy for mood and anxiety disorders: A latent profile analysis of short-term outcomes [0.03%]
氯胺酮治疗情绪及焦虑障碍的个性特征和创伤史：短期疗效潜在剖面分析
Nina Gregoire,Ethan Klukas,Kimberley Kaseweter et al.
Nina Gregoire et al.
Rationale: Ketamine-assisted therapy is emerging as a fast-acting intervention for treatment-resistant depression and anxiety. However, individual response to treatment varies, and little is known about how personality tr...
Genetic mapping in collaborative cross mouse strains identifies loci that affect initial sensitivity to cocaine [0.03%]
遗传连锁分析发现协同杂交小鼠品系中影响可卡因初次接触后反应的基因位点
Sarah A Schoenrock,Christiann H Gaines,Padam Kumar et al.
Sarah A Schoenrock et al.
Rationale: Cocaine use disorder (CUD) is a significant health concern that has devastating impacts on affected individuals and society. There are currently no approved therapies to treat CUD due, in part, to significant g...
Provider perspectives on challenges in treatment during psychedelic therapy [0.03%]
精神活性物质治疗中的治疗挑战及应对措施：供者视角
David A Bender,Sandeep M Nayak,Joshua S Siegel et al.
David A Bender et al.
Rationale: Psychedelic treatments are considered to involve unique treatment challenges relative to other psychiatric interventions, though these are typically not explored in detail within clinical trial reports. ...
Haloperidol - norepinephrine synergy in stimulation of vacuous chewing movements in rats: Enhancement by nicotine [0.03%]
氟哌啶醇与去甲肾上腺素诱导大鼠空嚼运动的协同作用及尼古丁对该协同作用的影响
Ilya D Ionov,Maria D Krasilova,Niсholas P Gorev et al.
Ilya D Ionov et al.
Rationale: Tardive dyskinesia (TD), a late onset involuntary repetitive movements, is a complication of antipsychotic therapy. The mechanism of TD development is currently obscure. In TD patients, an increased brain level...
Agmatine ameliorates morphine-induced behavioral sensitization through blood-brain barrier protection and anti-neuroinflammatory effects in the nucleus accumbens [0.03%]
ags可通过保护血脑屏障和降低伏核神经炎症反应来改善吗啡引起的behavioralsensitization
Haotian Ma,Wenrong Tian,Jing Xiao et al.
Haotian Ma et al.
The treatment of morphine addiction remains a significant clinical challenge, and the development of novel pharmacotherapies for opioid use disorder (OUD) is imperative. Agmatine, an endogenous neuromodulator, has promising antiaddictive po...
Autonomic nervous system reactivity to alcohol-related cues in cocaine use disorder: vagal-sympathetic balance and clinical implications [0.03%]
阿片类药瘾患者接触酒精线索时的自主神经反应性：副交感神经系统-交感神经系统的平衡及临床意义
Pierpaolo Congia,Maria Gabriella Brundu
Pierpaolo Congia
Rationale: Chronic substance use disrupts autonomic nervous system (ANS) function, altering stress and reward processing. The clinical significance of autonomic responses to alcohol-related stimuli in cocaine use disorder...
Effects of kappa-opioid receptor stimulation on addiction-related behavior in female rats: differences along the rostro-caudal axis of the nucleus accumbens shell [0.03%]
κ-阿片受体在雌鼠与成瘾相关行为中的作用：腹壳核头尾轴不同区域的差异性研究
Annie Hawks,Mary B Spodnick,Malcolm C Jennings et al.
Annie Hawks et al.
Rationale: Affective behavioral effects of kappa-opioid receptor (KOR) stimulation have been found to vary between the rostral and caudal nucleus accumbens (NAc) shell, but this has so far only been demonstrated in males....