Comparison of next-morning residual effects by bedtime administration of vornorexant and zopiclone in healthy older participants: postural stability, neuropsychological functions, and subjective sleepiness in a randomized clinical study [0.03%]
一项随机临床研究：在健康老年参与者中对比vornorexant和zopiclone晚间给药后清晨残留效应：姿势稳定性、神经心理功能和主观嗜睡感
Yusuke Miyazaki,Daiji Kambe,Yumiko Imadera et al.
Yusuke Miyazaki et al.
Rationale: Vornorexant is a novel dual orexin receptor antagonist for insomnia treatment with the shortest half-life in its class. Objective: ...
TM5441, a PAI-1 inhibitor, attenuates chronic stress-induced anxio-depressive-like behaviors by restoring the hippocampal PAI-1/tPA/BDNF axis [0.03%]
PAI-1抑制剂TM5441通过恢复海马区PAI-1/tPA/BDNF轴治疗慢性应激诱导的类似焦虑和抑郁的行为反应
Amine Bahi,Jean-Luc Dreyer
Amine Bahi
Rationale: Chronic unpredictable mild stress (CUMS) is a validated model of anxiety- and depression-like disorders and is associated with impaired neuroplasticity. Dysregulation of the plasminogen activator system, partic...
Probing the habitual and compulsive-like basis of (dys)functional checking in the Observing Response Task, a rodent analogue relevant to obsessive-compulsive disorder [0.03%]
探究强迫检查行为的习惯性和类似强迫症的基础——与强迫症相关的啮齿动物观察反应任务中的功能和非功能检查行为研究
Luise Pickenhan,Amy L Milton
Luise Pickenhan
Rationale: Excessive and maladaptive checking is a prominent symptom of obsessive-compulsive disorder (OCD). This dysfunctional checking can be modelled using the Observing Response Task (ORT), which distinguishes between...
Shorter to be effective: subanesthetic-dose ketamine infusion reduces the global and regional path length of brain functional connectivity in patients with treatment-resistant depression and suicidal ideation [0.03%]
短剂量氯胺酮快速减低难治性抑郁症患者功能连接的全局效率及部位特异性效率从而快速减少自杀风险：一项随机对照研究
Wei-Chen Lin,Li-Kai Cheng,Tung-Ping Su et al.
Wei-Chen Lin et al.
Background: Studies have demonstrated that subanesthetic-dose ketamine may modulate the functioning of specific depression-related brain regions, particularly the anterior cingulate cortex and prefrontal cortex. However, ...
Golden window of intervention in PTSD: a synthesis of preclinical evidence [0.03%]
PTSD的干预窗口：前临床证据综合分析
Dharshini Padmavathi Kannan,Manorathna Arun,Sathvigha Ravi et al.
Dharshini Padmavathi Kannan et al.
Rationale: In the aftermath of trauma exposure, timing of clinical intervention is of crucial importance to prevent progression of disease symptoms. Present treatments sometimes fail to correct the whole range of symptoms...
Transcriptional profiling reveals brain region-specific changes in gene expression induced by chronic unpredictable mild stress between stress-susceptible and stress-resilient mice [0.03%]
转录组分析揭示慢性轻度不可预测应激在易感和耐受小鼠特定脑区的基因表达变化
Xiaoyu Chen,Yi Cao,Xianlong Zhao et al.
Xiaoyu Chen et al.
Rationale: Depression is a common psychiatric disorder characterized mainly by low mood, anhedonia, and sleep disturbances. In severe cases, it can lead to suicidal tendencies and behaviors. Chronic stress can induce depr...
Correction to: Prospective examination of synthetic 5-methoxy-N, N-dimethyltryptamine inhalation: effects on salivary IL-6, cortisol levels, affect, and non-judgment [0.03%]
Synthetic 5-甲氧基-N，N-二甲基色胺吸入的前瞻性检查：对唾液IL-6、皮质醇水平、情绪和非判断的影响的更正通知
Malin V Uthaug,Rafael Lancelotta,Attila Szabo et al.
Malin V Uthaug et al.
Published Erratum
Psychopharmacology. 2026 May 19. DOI:10.1007/s00213-026-07086-9 2026
β-caryophyllene, a CB2-selective phytocannabinoid, differentially modulates attention and inhibitory control in low- and high-performing young and aged mice [0.03%]
β-石竹烯是一种CB2选择性植物大麻素，可调节低表现力和高表现力年轻小鼠及年老小鼠的注意力和抑制控制行为
Williams M N,Patel N T,Fleischel E J et al.
Williams M N et al.
Rationale: Evidence suggests that modulation of cannabinoid signaling via CB2 receptors regulates neuroinflammation and confers neuroprotection, positioning these receptors as promising targets for age-related cognitive d...
Spironolactone and clinical outcomes in patients with alcohol use disorder and comorbid hypertension: a target trial emulation study [0.03%]
螺内酯和酒精使用障碍合并高血压患者的临床结局：一种靶向试验仿真研究
Anna Loften,QuanQiu Wang,Mehdi Farokhnia et al.
Anna Loften et al.
Rationale: Alcohol use disorder (AUD) is a major contributor to the global burden of disease, yet treatments are limited. Therefore, developing evidence-based pharmacotherapies for AUD is critical. Preclinical and clinica...
16p11.2 duplication and NMDA receptor antagonism have distinct impacts on reward learning and decision making [0.03%]
16p11.2重复和N-甲基-D天冬氨酸受体拮抗对奖赏学习及决策有不同的影响
Dana Mueller,Evan Knep,Angelica Velosa et al.
Dana Mueller et al.
Rationale: 16p11.2 duplication is associated with numerous neuropsychiatric conditions at a genome-wide level, including psychosis. Mice modeling 16p11.2 duplication may provide important insights into cognitive risk fact...