Optogenetic stimulation of the infralimbic cortex prior to fear extinction learning rescues deficits in a preclinical model of comorbid PTSD and AUD [0.03%]
在恐惧消退学习前对下肢皮层进行光遗传刺激可拯救共病型创伤后应激障碍和酒精使用障碍的小鼠模型中的缺陷现象
Liza J Wills,Bailey Adams,Britta Schwartz et al.
Liza J Wills et al.
Rationale: Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) frequently co-occur, leading to significant impairments in learning and memory. Despite the prevalence of these disorders, existing treatment...
Histone deacetylase inhibitor sodium butyrate increases risk-taking during acquisition of the rat gambling task [0.03%]
丁酸钠通过增加赌任务中获得阶段的风险行为来发挥作用
Kelly M Hrelja,Stephanie Hipkin,Brett A Hathaway et al.
Kelly M Hrelja et al.
Rationale: Pairing casino-inspired audiovisual cues with reward delivery significantly increases risky decision-making in laboratory-based gambling tasks across rats and humans. The neurocognitive mechanisms underlying th...
Divergent effects of ketamine and psilocybin on EEG power spectral density in a mismatch negativity paradigm [0.03%]
氯胺酮和裸盖菇素对Mismatch Negativity范式下EEG功率谱密度的差异影响研究
Milad Soltanzadeh,Zheng Wang,Shona G Allohverdi et al.
Milad Soltanzadeh et al.
Rationale: Ketamine and psilocybin have demonstrated therapeutic potential for mental disorders, including major depressive disorder, yet they engage distinct mechanisms of action. Ketamine, a dissociative hallucinogen, a...
Endocannabinoid response to social stress in chronic non-medical prescription opioid users [0.03%]
慢性非医学用途阿片类药物使用者对社交压力的内源大麻素反应
Vinzenz K Schmid,Boris B Quednow,Daniele Pellegata et al.
Vinzenz K Schmid et al.
Rationale: The ongoing global opioid crisis underscores the need to better understand the neurobiological mechanisms underlying opioid use disorder (OUD). Stress is a key risk factor for developing and maintaining OUD. Wh...
Lifeng Qian,Qing Yao,Yanglei Jiang et al.
Lifeng Qian et al.
Rationale: Depression is a common and serious mental disorder that has a significant impact on the quality of life of patients. Currently, the clinical drugs used to treat depression all have certain limitations in their ...
PIWI-Interacting RNAs in brain health and disease: biogenesis, mechanisms, and therapeutic horizons [0.03%]
Piwi相互作用RNA在脑健康和疾病中的作用：生成、机制及治疗前景
Yuang Cai,Shaoyuan Huang,Yifan Dong et al.
Yuang Cai et al.
PIWI-interacting RNAs (piRNAs), a class of small non-coding RNAs originally identified for their role in transposon silencing in germ cells, have recently been recognized as pivotal regulators of gene expression in the central nervous syste...
Marked sex differences are observed in heroin acquisition and affective states in rats but converge to similar levels of footshock stress-induced reinstatement [0.03%]
吗啡复吸的性别二态性及其应激诱发的跨性别收敛性研究
Claire Deckers,Zeinab Ahmed,Chen Li et al.
Claire Deckers et al.
Rationale: Negative affective states, particularly those driven by stress, are known to trigger the development of opioid addiction and relapse. Previous preclinical research has identified sex differences in vulnerabilit...
Cross-modal conflict control deficits in male patients with substance use disorder are primarily associated with the response level [0.03%]
男性物质使用障碍患者跨模式冲突控制缺陷主要与反应水平有关
Jiwen Zhang,Heng Zhou,Yulin Gao et al.
Jiwen Zhang et al.
Rationale: Cross-modal conflict control (CMCC) refers to the ability to prioritize information from one sensory modality while suppressing interference from another when presented with incongruent stimuli. Patients with s...
The sensitivity of adult zebrafish to clinically relevant neuroactive (sedative) effects of extracts of selected traditional Chinese medicine herbs [0.03%]
几种常用中药提取物的成人斑马鱼神经活性（镇静）效应及敏感性研究
Dongmei Wang,Longen Yang,David S Galstyan et al.
Dongmei Wang et al.
Rationale: Traditional Chinese Medicine (TCM) continues to play an important role in modern medicine. TCM herbs are commonly used to treat various brain disorders, including anxiety and depression. Complementing rodent st...
Methamphetamine and α-pyrrolidinopentiophenone (α-PVP) intravenous self-administration in female and male rats [0.03%]
甲基苯丙胺和α-吡咯烷翁戊酚酮（α-PVP）在雌雄大鼠体内的自我注射行为研究
Arnold Gutierrez,Yanabel Grant,Sophia A Vandewater et al.
Arnold Gutierrez et al.
Rationale: Stimulant drug users vary in their substance of choice and may, in some cases, switch up their preferred substance based on availability, cost or other factors. Poly-substance use is rarely assessed in rodent m...