Blinding, Expectancy, and the Active Placebo Paradox in MDMA Research [0.03%]
甲基苯丙胺实验中的盲法、预期效果和活性安慰剂悖论
Mitch Earleywine,Quinn Allen
Mitch Earleywine
Attitudes and perceptions of psychedelic therapy among clinical trial participants with alcohol use disorder: a mixed-method study [0.03%]
酒精使用障碍临床试验参与者对迷幻疗法的态度和认知：一项混合方法研究
Julian Kirsch,Christopher Poppe,Anne Beck et al.
Julian Kirsch et al.
Background: Alcohol use disorder (AUD) remains a major global health concern, with high morbidity and mortality and limited long-term treatment success. Psychedelic therapy has re-emerged as a potential novel intervention...
The influence of HINT1 protein in nucleus accumbens on aggressive behavior and anxiety-like behavior [0.03%]
HINT1蛋白在伏隔核中对攻击行为和类似焦虑行为的影响
Yongkang Ma,Dianying Liu,Ruichao Wen et al.
Yongkang Ma et al.
Objective: Histidine triad nucleotide-binding protein 1 (HINT1), implicated in psychiatric disorders, is highly expressed in the nucleus accumbens (NAc). Although previous work has linked HINT1 to aggression and anxiety, ...
Improving translational insight using sequential sampling models in drug choice [0.03%]
利用药物选择中的连续采样模型提高翻译洞察力
Bart J Cooley,E Zayra Millan,Gavan P McNally
Bart J Cooley
The translation of pharmacological treatments for alcohol use disorder (AUD) remains challenging despite advances in neuroscientific and molecular sciences enabling unprecedented levels of analysis. We propose that formal characterization o...
Impact of sex on heroin intravenous self-administration by heterogeneous stock rats [0.03%]
性别对杂合品系大鼠海洛因静脉自我注射的影响
Michael A Taffe,Sydney L Mehl,Sara R M U Rahman et al.
Michael A Taffe et al.
Background: Intravenous self-administration (IVSA) of opioids by rats has been shown frequently to exhibit no sex differences, in many cases a higher intake of females, and only rarely higher rates in males. A diversity o...
Reinforcement sensitivity phenotype modulates the impact of chronic stress on hedonic capacity in rats, but not the response to fluoxetine [0.03%]
慢性压力对大鼠享乐能力的影响受增强敏感型表型的调节，但不影响氟西汀的反应
Agata Cieslik-Starkiewicz,Michal Piksa,Karolina Noworyta et al.
Agata Cieslik-Starkiewicz et al.
Introduction: Depression is a heterogeneous psychiatric disorder shaped by the interaction between environmental stress and individual traits, such as reinforcement sensitivity. These traits influence how individuals proc...
Effects of chemotherapy on cognitive and physical effort-based decision-making tasks in rats [0.03%]
化疗对大鼠认知和体力努力决策任务的影响
Weiye Chen,Ian N Johnston
Weiye Chen
Rationale: Cancer-related fatigue is one of the most reported issues following cancer and its treatment, affecting the quality of life of cancer patients and survivors. However, the effects of chemotherapy on motivational...
No differences in inhibitory control or prefrontal activation during a cannabis cue stop-signal task across CUDIT-R-defined CUD-risk groups [0.03%]
基于CUDIT-R界定的CUD风险组在大麻线索停止信号任务中的抑制控制和前额叶激活无差异
Christopher R Pickering,Valentina Lorenzetti,Andrew Jones et al.
Christopher R Pickering et al.
Rationale: Cannabis use continues to increase globally, with a growing proportion of users exhibiting problematic patterns of use. Although neural differences in reward and inhibitory control systems are commonly reported...
Mazen A Atiq,Eli Weisman,Rodrigo B Guerra et al.
Mazen A Atiq et al.
Background: Psilocybin is among the serotonergic psychedelics closest to potential FDA approval, with growing evidence of therapeutic benefit across psychiatric conditions. As clinical trials expand, systematic characteri...
Dissociation between the dynamics of symptom scores and network metrics in psychosis treatment: a proof-of-concept study using network intervention analysis [0.03%]
精神病治疗中症状评分动力学与网络度量的分离：使用网络干预分析的概念验证研究
Pierfrancesco Sarti,Giacomo Cecere,Wolfgang Omlor et al.
Pierfrancesco Sarti et al.
Rationale: Antipsychotic efficacy in schizophrenia spectrum disorders (SSD) is commonly evaluated using static measures that fail to capture the dynamic evolution of symptoms and the unfolding impact of treatment over tim...