Pharmacodynamic effects and plasma pharmacokinetics of N, N-dimethyltryptamine after intranasal versus subcutaneous administration in male rats [0.03%]
鼻腔给药与皮下注射对雄性大鼠N,N-二甲基色胺血药浓度-时间曲线及药效学的影响研究
Michael H Baumann,Grant C Glatfelter,Sara E Walton et al.
Michael H Baumann et al.
Rationale: There is growing interest in the therapeutic utility of psychedelic compounds that act as serotonin-2 A receptor (5-HT2A) agonists. N,N-dimethyltryptamine (DMT) is a 5-HT2A agonist that produces intense and sho...
(R)-Ketamine reduces alcohol intake and alcohol seeking induced by reconsolidation of alcohol-related memories in female Marchigian Sardinian alcohol-preferring rats [0.03%]
光学消旋ketamine通过干扰酒精相关记忆的再巩固过程减少雌性MSrats的酒精摄入和觅酒行为
Elisabetta Ciccocioppo,Sara Massetti,Marcus W Meinhardt et al.
Elisabetta Ciccocioppo et al.
Background: Alcohol use disorder (AUD) represents a significant medical challenge, with available therapeutic approaches having limited efficacy. Emerging data suggest that psychedelic compounds could represent an alterna...
Clinical and preclinical evidence of sex differences in nicotine-induced enhancement of alcohol self-administration [0.03%]
尼古丁诱导的酒精自给行为增强的性别差异的临床和预临床证据
Vernon Garcia-Rivas,Yasmin Zakiniaeiz,C Leonardo Jimenez Chavez et al.
Vernon Garcia-Rivas et al.
Rationale: Alcohol and nicotine are frequently co-used, with significant implications for public health, particularly for women. Nicotine is known to enhance the response to other reinforcers in the immediate environment,...
Behavioral impact of chemogenetic manipulations of 5-HT DRN neurons in transgenic Tph2-iCre rats [0.03%]
化学遗传学操控Tph2-iCre转基因大鼠腹中缝背核5-ht神经元的行为学效应
Nicholas S McCloskey,Chen Li,Lynn G Kirby
Nicholas S McCloskey
Rationale: Our laboratory has demonstrated that stressors regulate the 5-HT system with consequences in behavioral models of psychiatric disorders including addiction. We have employed behavioral pharmacology methods to s...
Targeting endoplasmic reticulum stress and protein misfolding in schizophrenia: the emerging promise of sigma-1 receptor agonists [0.03%]
针对精神分裂症的内质网应激和蛋白错误折叠：σ-1受体激动剂的前景
Mariam K Ahmed,Kareem Abdou,Weam W Ibrahim et al.
Mariam K Ahmed et al.
Schizophrenia is a severe psychiatric disorder marked by significant cognitive, perceptual, and social deficits, the neurobiological basis of which remains incompletely elucidated. Increasing evidence implicates disruptions in protein homeo...
Characterisation of a touchscreen-based task for assessing cognitive judgement bias in mice: a new translational tool for affective state disorder drug screening [0.03%]
一种基于触摸屏的任务用于评估小鼠认知判断偏倚的特点：一种新的情感状态障碍药物筛选的转化工具
Laura Lopez-Cruz,Benjamin U Phillips,Lisa M Saksida et al.
Laura Lopez-Cruz et al.
Rationale: A major obstacle in the pre-clinical study of mood-related disorders and novel affective state therapeutic evaluation is the lack of animal models that fully recapitulate human symptomatology. ...
Investigating antidiabetic drug targets as potential therapeutic modulators for schizophrenia [0.03%]
探究抗糖尿病药物作用机制作为潜在的精神分裂症治疗调变剂
Yu-Sheng Huang,Xu Lin,Ya-Juan Xu et al.
Yu-Sheng Huang et al.
Rationale: Certain types of antidiabetic drugs (ADs) have been proven to improve cognitive functions and symptom dimensions in schizophrenia (SCZ). Object...
Intact neurophysiological markers of death denial in long-term ayahuasca users [0.03%]
长期使用ayahuasca者的死亡否认的神经生理标志完整无损
Yair Dor-Ziderman,Jonathan David,Aviva Berkovich-Ohana
Yair Dor-Ziderman
Rationale: There is growing enthusiasm around the potential of psychedelics to transform how individuals engage with the theme of death, with self-report evidence suggesting these substances foster acceptance and reduce f...
Intranasal vasopressin, but not oxytocin, decreases ethanol intake in socially housed mice [0.03%]
社会饲养的小鼠鼻内给药加压素而非催产素可减少酒精摄入量
Michelle A Nipper,Jonathan A Zweig,Michael C Johnson et al.
Michelle A Nipper et al.
Rationale: Oxytocin decreases alcohol consumption across a variety of non-human animal models. However, clinical trials using this peptide have produced mixed results. Among the reasons for difficulties in translating pre...
Risky decision-making in the balloon analogue risk task - the role of noradrenaline and cortisol [0.03%]
与去甲肾上腺素和皮质醇相关的气球冒险任务中的决策行为研究
Kim Fricke,Nina Alexander,Thomas Jacobsen et al.
Kim Fricke et al.
Rationale: Stress can significantly alter decision-making, often promoting riskier choices. While prior research suggests a link between acute stress and increased risk-taking, the specific contributions of cortisol and n...