OPRD1 rs4654327 and Outcomes of Extended-Release Naltrexone in Alcohol Use Disorder: An Exploratory Prospective Pharmacogenetic Study [0.03%]
OPRD1基因多态性与纳曲酮缓释剂治疗酒精使用障碍效果的药理遗传学研究
Valentin Skryabin,Sergei Miroshkin,Anton Masyakin et al.
Valentin Skryabin et al.
Background: Extended-release naltrexone is an established pharmacological strategy for preventing relapse in alcohol use disorder (AUD), yet substantial interindividual variability in treatment response remains unexplaine...
Comparative effects of inactivation and dopamine receptor agents in the dorsolateral and dorsomedial striatum on performance of action sequences in rats [0.03%]
大鼠背外侧和背内侧纹状体失活及多巴胺受体作用于动作序列操作性能的比较效应
Karly M Turner,Anna Svegborn,Trevor W Robbins
Karly M Turner
Rationale: Recent research on habits and skills has produced a wave of new theories regarding the shift in control from medial to lateral regions of the dorsal striatum, and how these regions are implicated in the selecte...
Peripheral oxytocin administration decreases the food intake and compulsive-like behavior in male rats in an animal model of binge-type eating [0.03%]
外周血管催产素给药可减少暴食型进食模型大鼠的摄食量和强迫行为
Yeimi J Cuellar-Salazar,Josué O Suárez-Ortiz,Juan M Mancilla-Díaz et al.
Yeimi J Cuellar-Salazar et al.
Hormone oxytocin is implicated in the control of food intake and energy balance. Experimental evidence indicates that oxytocin reduces carbohydrate intake, motivation and seeking for palatable foods. We recently showed that intermittent int...
Beyond cannabis use severity: associations of cannabis product type with sleep quality and mental health [0.03%]
超越大麻使用严重程度：大麻产品类型与睡眠质量和精神健康之间的关联
Ana Paula Gonçalves Donate,Janna Cousijn,Kristine Rømer Thomsen
Ana Paula Gonçalves Donate
Rationale: People who use cannabis often report using it to improve sleep and/or manage mental health symptoms. Cannabis products differ in their typical cannabinoid composition, particularly in their relative THC and CBD...
The relationship between duration of access to intravenous oxycodone self-administration, economic demand for oxycodone, and cognition in rats [0.03%]
大鼠静脉自给氧可酮持续时间、经济需求和认知之间的关系
Sydney Dick,Amy Heaton,Aaron D Claypool et al.
Sydney Dick et al.
Rationale: Individuals who use opioids display cognitive deficits. Objectives: Here we used oxycodone intravenous self-administration (...
Effects of repeated low-dose LSD on neuropsychological functioning in adults with ADHD: a randomized placebo-controlled study [0.03%]
重复小剂量服用LSD对注意缺陷多动障碍成人神经心理功能的影响：一项随机双盲安慰剂对照研究
E C H M Haijen-Bongers,P P M Hurks,J Schepers et al.
E C H M Haijen-Bongers et al.
Rationale: Attention-deficit hyperactivity disorder (ADHD) shows substantial heterogeneity in symptoms and cognitive deficits. According to the Triple Pathway Model, this variability may stem from impairments in three neu...
Novel dopamine 4 receptor ligands differentially ameliorate ADHD-like behaviors in spontaneously hypertensive rats [0.03%]
新型多巴胺4受体配体可改善 SHR 的注意缺陷障碍行为
Ike C de la Peña,Samantha Andino,Ashley Amis et al.
Ike C de la Peña et al.
Rationale: Dopamine D4 receptors (D4Rs) have been implicated in the pathophysiology of attention-deficit/hyperactivity disorder (ADHD), yet their precise role and therapeutic relevance remain underexplored. Highly selecti...
Pierre Klintefors,Chiranth Bhagavan,Richard Kanaan et al.
Pierre Klintefors et al.
Rationale: Clinical interest in psilocybin-assisted rehabilitation for motor disorders is growing. However, psilocybin's motor effects are under-researched, and quantifying them is essential for assessing treatment risks ...
Diazepam selectively biases approach during threat-reward conflict while sparing reactive avoidance [0.03%]
地西泮选择性地偏向于在威胁-奖励冲突期间产生倾向作用，而不影响反应性的回避行为
Óscar Enciso-Pablo,Félix Sierra-Ramírez,Francisco Sotres-Bayon
Óscar Enciso-Pablo
Rationale: Benzodiazepines are widely used to treat anxiety; however, their influence on defensive behavior when threats compete with rewards remains unclear. ...
Mood stabilizers and systemic inflammatory burden in euthymic patients with bipolar disorder: a comparative study of lithium and valproate [0.03%]
情绪稳定剂与双相情感障碍患者正常的炎性负担：锂和丙戊酸的比较研究
Hasan Bakay,Fatmanur Akgün Kılavuz
Hasan Bakay
Rationale: Systemic inflammation is increasingly recognized as a key component of the pathophysiology and neuroprogression of bipolar disorder (BD). Novel hematologic indices, including the NLR, PLR, SII, SIRI, and PIV, p...