The nonpeptide angiotensin-(1-7) mimic AVE0991 attenuates neuroendocrine and behavioral responses to chronic unpredictable stress [0.03%]
一种非肽类血管紧张素-(1-7)拟似物(AVE0991)能够缓解慢性不可预见性压力引起的神经内分泌及行为应激反应
Maria Luiza Antunes Fonseca,Laura Beatriz de Oliveira Amaral,Sthéfanie C A Gonçalves et al.
Maria Luiza Antunes Fonseca et al.
Rationale: Chronic stress, frequently associated with dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis and reduced neuroplasticity, is a major risk factor for psychiatric disorders such as anxiety and depressi...
Sex differences in stress responding in a randomized, placebo-controlled clinical trial of progesterone in cannabis use disorder [0.03%]
一项关于大麻使用障碍的随机、安慰剂对照临床试验中的应激反应性别差异
Erin L Martin,Nathaniel L Baker,Brian Neelon et al.
Erin L Martin et al.
Rationale: Stress is a major contributor to relapse in individuals with cannabis use disorder (CUD). Stress responding in individuals with CUD differs by sex, suggesting a potential role for sex hormones in stress modulat...
Mitragynine reduces methamphetamine self-administration in rats without disrupting food-maintained responding [0.03%]
密特拉嘎林减少methamphetamine自给而不干扰食物维持反应
Lida Khodavirdilou,Julio D Zuarth Gonzalez,Sushobhan Mukhopadhyay et al.
Lida Khodavirdilou et al.
Rationale: Kratom (Mitragyna speciosa), a plant native to Southeast Asia, has become popular in the United States for its reported ability to treat substance use disorders (SUD). Mitragynine (MG) is the most abundant alka...
Sotagliflozin pretreatment attenuates acute LPS-induced depression-like behavioral abnormalities and modulates the gut microbiota-immune-brain axis [0.03%]
索塔格利弗林干预可减轻急性脂多糖诱导的类似抑郁的行为异常并调节肠菌-免疫-脑轴反应
Jun Zeng,Lihuimei Zhou,Lei Liao et al.
Jun Zeng et al.
Rationale: Inflammation-driven depression is increasingly recognized as a major therapeutic target, yet effective pharmacological strategies remain limited. Sotagliflozin (SOTA), a dual inhibitor of sodium-glucose cotrans...
GlyT1 inhibition enhances working memory in the mouse TUNL task and normalizes NMDA antagonist-induced network activity [0.03%]
甘氨脱氧胆酸转运蛋白1抑制剂能增强小鼠在TUNL任务中的工作记忆并可纠正N-甲基-D天冬氨酸受体拮抗剂所致的神经网络异常放电
Bastiaan van der Veen,Tudor M Ionescu,Serena Deiana et al.
Bastiaan van der Veen et al.
Rationale: Working memory deficits are a core feature of psychiatric disorders such as schizophrenia and bipolar disorder, yet effective pharmacological strategies remain elusive. The trial unique non-matching to location...
Effects of repeated treatment with opioids that vary in mu opioid receptor efficacy on pain-depressed locomotor behavior in mice [0.03%]
阿片类药物重复治疗对小鼠疼痛抑制运动行为的影响
Jawaun Harris,Dana R Chambers,Delmis E Hernandez et al.
Jawaun Harris et al.
Rationale: Mu opioid receptor (MOR) analgesics like morphine have high intrinsic MOR efficacy but produce side effects. Lower efficacy MOR agonists like buprenorphine can produce analgesia with improved safety. We recentl...
Cannabidiol in the anterior insular cortex attenuates chronic neuropathic pain and comorbid anxiety- and depression-like behaviors: involvement of CB1 and 5-HT1A receptor signaling [0.03%]
大麻二酚通过作用于前绝缘皮层的大麻素1受体和五羟色胺受体信号减轻慢性神经性疼痛及共病的焦虑抑郁样行为
Renata Moreira Acunha,Bruna Rabelo Ribeiro Domingues,Nubia Barros et al.
Renata Moreira Acunha et al.
Background: Chronic neuropathic pain (NP) is frequently accompanied by anxiety- and depression‑like symptoms, reflecting maladaptive interactions between nociceptive and affective brain networks. The anterior insular cor...
Fentanyl decreases arterial blood oxygen saturation more than furanylfentanyl in mice due to increased apnea [0.03%]
芬太尼通过增加屏气更大幅度地降低小鼠动脉血氧饱和度而超越呋喃芬太尼
Catherine Demery,Sierra C Moore,Kelsey E Kochan et al.
Catherine Demery et al.
Rationale: Fatal opioid overdoses involving synthetic opioids have increased >10-fold over the past 8 years. Fentanyl, a potent synthetic opioid acting at the mu-opioid receptor (MOR), has largely replaced heroin as the p...
Suicide attempt risk among patients receiving methylphenidate: a retrospective cohort study [0.03%]
一项关于接受甲基苯丙胺治疗患者的自杀企图风险的回顾性队列研究
Tai-Long Pan,Li-Chi Chen,Ju-Wei Hsu et al.
Tai-Long Pan et al.
Background: Methylphenidate may reduce suicide risk among patients with attention-deficit hyperactivity disorder. Several studies have noted that the association between methylphenidate use and suicidality is weakening. ...
Investigating the impact of serotonergic psychedelic drugs, MDMA and ketamine on social cognition in psychiatric disorders: A scoping review [0.03%]
血清素致幻剂药物MDMA和氯胺酮对精神疾病社交认知的影响：综述研究
Sarah Ann Smith,Haseeb Mohammad,Lik Hang N Lee et al.
Sarah Ann Smith et al.
Rationale: Interest in psychedelic drugs has increased rapidly because of their potential therapeutic role in psychiatric disorders. Impairments in the sociocognitive skills needed to build and maintain social relationshi...