1,8-Cineole blocks voltage-gated L-type calcium channels in tracheal smooth muscle [0.03%]
1,8-薄荷烯通过阻断气管平滑肌细胞L型电压控制钙通道产生解痉作用
Átila Pereira-Gonçalves,Francisco Walber Ferreira-da-Silva,Camille Maria de Holanda-Angelin-Alves et al.
Átila Pereira-Gonçalves et al.
1,8-Cineole is a cyclic monoterpenoid used in folk medicine for treatment of numerous respiratory diseases and other infections. 1,8-Cineole has anti-inflammatory, antioxidant, and myorelaxant effects, as well as low toxicity. In the presen...
Serotonergic neuron ADF modulates avoidance behaviors by inhibiting sensory neurons in C. elegans [0.03%]
五羟色胺能神经元ADF通过抑制感觉神经元调控秀丽隐杆线虫的回避行为
Jiajie Shao,Xiaoyan Zhang,Hankui Cheng et al.
Jiajie Shao et al.
Serotonin plays an essential role in both the invertebrate and vertebrate nervous systems. ADF, an amphid neuron with dual ciliated sensory endings, is considered to be the only serotonergic sensory neuron in the hermaphroditic Caenorhabdit...
Potential therapeutic value of transient receptor potential channels in male urogenital system [0.03%]
瞬时受体电位通道在男性泌尿生殖系统治疗中的潜在价值
Gamze Toktanis,Ecem Kaya-Sezginer,Didem Yilmaz-Oral et al.
Gamze Toktanis et al.
Transient receptor potential (TRP) channels comprise a family of cation channels implicated in a variety of cellular processes including light, mechanical or chemical stimuli, temperature, pH, or osmolarity. TRP channel proteins are a diver...
Expression cloning human and rat renal cortex Na/Pi cotransporters: behind the scenes in the Murer laboratory [0.03%]
人类和大鼠肾皮质Na/Pi同向转运蛋白的表达克隆：穆尔尔实验室台前幕后的故事
Simona Magagnin,Andreas Werner
Simona Magagnin
In the pre-genomic era, the cloning of a cDNA represented a significant achievement, particularly if the gene of interest encoded a membrane protein. At the time, molecular probes such as partial peptide sequences, suitable nucleic acid seq...
Cristina Fenollar-Ferrer,Lucy R Forrest
Cristina Fenollar-Ferrer
Progress towards understanding the molecular mechanisms of phosphate homeostasis through sodium-dependent transmembrane uptake has long been stymied by the absence of structural information about the NaPi-II sodium-phosphate transporters. F...
The voltage-sensitive cardiac M2 muscarinic receptor modulates the inward rectification of the G protein-coupled, ACh-gated K+ current [0.03%]
电压敏感型心脏M2胆碱能受体调节由G蛋白偶联的乙酰胆碱门控钾电流的内向整流作用
Pedro D Salazar-Fajardo,Iván A Aréchiga-Figueroa,Ana Laura López-Serrano et al.
Pedro D Salazar-Fajardo et al.
The acetylcholine (ACh)-gated inwardly rectifying K+ current (IKACh) plays a vital role in cardiac excitability by regulating heart rate variability and vulnerability to atrial arrhythmias. These crucial physiological contributions are dete...
Glucose-regulated protein 78 in lipid rafts elevates vascular smooth muscle cell proliferation of spontaneously hypertensive rats by controlling platelet-derived growth factor receptor signaling [0.03%]
网格蛋白依赖的脂筏中葡萄糖调节蛋白78通过调控血小板源性生长因子受体信号促进自发性高血压大鼠血管平滑肌细胞增殖
Do-Yoon Kim,Dae Il Hwang,Soo Min Park et al.
Do-Yoon Kim et al.
The multifunctional glucose-regulated protein 78 (GRP78) is known to be differentially expressed in the lipid rafts of vascular smooth muscle cells (VSMCs) from spontaneously hypertensive rats (SHRs) and normal Wistar-Kyoto (WKY) rats. Howe...
Renal expression and urinary excretion of Na+/dicarboxylate cotransporter 1 (NaDC1) in obstructive nephropathy: a candidate biomarker for this pathology [0.03%]
阻塞性肾病的钠/二羧酸盐同向转运体1（NaDC1）在肾脏中的表达及其尿液排泄：作为该疾病生物标志物的候选者
Romina V Campagno,María J Severin,Evangelina C Nosetto et al.
Romina V Campagno et al.
Obstructive nephropathy is characterized by alterations in renal function that depends on the degree and type of obstruction. To increase the knowledge about the physiopathological mechanisms involved in the renal damage associated with bil...
Su-Kyung Shin,Hyun-Woo Cho,Seung-Eun Song et al.
Su-Kyung Shin et al.
Obesity and insulin resistance are considered the main causes of nonalcoholic fatty liver disease (NAFLD), and oxidative stress accelerates the progression of NAFLD. Free fatty acids, which are elevated in the liver by obesity or insulin re...
Transcripts of Kv7.1 and MinK channels and slow delayed rectifier K+ current (IKs) are expressed in zebrafish (Danio rerio) heart [0.03%]
斑马鱼心脏中慢延迟整流钾电流通道Kv7.1和MinK的转录表达
Denis V Abramochkin,Minna Hassinen,Matti Vornanen
Denis V Abramochkin
Zebrafish are increasingly used as a model for human cardiac electrophysiology, arrhythmias, and drug screening. However, K+ ion channels of the zebrafish heart, which determine the rate of repolarization and duration of cardiac action pote...