Clinical aspects of the phosphate transporters NaPi-IIa and NaPi-IIb: mutations and disease associations [0.03%]
磷酸盐转运蛋白NaPi-IIa和NaPi-IIb的临床方面：突变与疾病关联
Eleanor Lederer,Carsten A Wagner
Eleanor Lederer
The Na+-dependent phosphate transporter NaPi-IIa (SLC34A1) is mostly expressed in kidney, whereas NaPi-IIb (SLC34A2) has a wider tissue distribution with prominent expression in the lung and small intestine. NaPi-IIa is involved in renal re...
Type II Na+-phosphate Cotransporters and Phosphate Balance in Teleost Fish [0.03%]
鱼类钠-磷酸盐同向转运蛋白CNPTR和磷平衡
Tiziano Verri,Andreas Werner
Tiziano Verri
Teleost fish are excellent models to study the phylogeny of the slc34 gene family, Slc34-mediated phosphate (Pi) transport and how Slc34 transporters contribute Pi homeostasis. Fish need to accumulate Pi from the diet to sustain growth. Muc...
Substrates and inhibitors of phosphate transporters: from experimental tools to pathophysiological relevance [0.03%]
磷酸盐转运调节剂：从实验工具到病理生理学意义
Víctor Sorribas,Natalia Guillén,Cecilia Sosa
Víctor Sorribas
The control of inorganic phosphate homeostasis is mediated through the activity of sodium-coupled Pi transporters located in the intestine, kidneys, and bone. To study these transporters in either the native tissue or after heterologous exp...
Systemic network for dietary inorganic phosphate adaptation among three organs [0.03%]
三种器官间适应膳食无机磷酸的系统网络
Kayo Ikuta,Hiroko Segawa,Ai Hanazaki et al.
Kayo Ikuta et al.
Inorganic phosphate (Pi) secretion from the salivary glands and dietary Pi are key Pi sources. The regulatory mechanisms of Pi homeostasis in the salivary glands are unknown. We investigated how salivary Pi concentrations are regulated by d...
Expression and function of Slc34 sodium-phosphate co-transporters in skeleton and teeth [0.03%]
骨骼和牙齿中的Slc34钠-磷共转运体的表达与功能
Laurent Beck
Laurent Beck
Under normal physiological condition, the biomineralization process is limited to skeletal tissues and teeth and occurs throughout the individual's life. Biomineralization is an actively regulated process involving the progressive mineraliz...
Robustness of the non-neuronal cholinergic system in rat large intestine against luminal challenges [0.03%]
大鼠结肠非胆碱能系统应对肠腔内挑战的稳定性研究
Sandra Bader,Stefanie Gerbig,Bernhard Spengler et al.
Sandra Bader et al.
Acetylcholine and atypical esters of choline such as propionyl- and butyrylcholine are produced by the colonic epithelium and are released when epithelial receptors for short-chain fatty acids (SCFA) are stimulated by propionate. It is assu...
Role of αKlotho and FGF23 in regulation of type II Na-dependent phosphate co-transporters [0.03%]
α-Klotho和FGF23在II型钠依赖性磷酸盐同向转运蛋白调节中的作用
Ming Chang Hu,Mingjun Shi,Orson W Moe
Ming Chang Hu
Alpha-Klotho is a member of the Klotho family consisting of two other single-pass transmembrane proteins: βKlotho and γKlotho; αKlotho has been shown to circulate in the blood. Fibroblast growth factor (FGF)23 is a member of the FGF supe...
Allelic imbalance and haploinsufficiency in MYBPC3-linked hypertrophic cardiomyopathy [0.03%]
MYBPC3基因连锁肥厚型心肌病的等位基因失衡和半合子不足现象
Amelia A Glazier,Andrea Thompson,Sharlene M Day
Amelia A Glazier
Mutations in cardiac myosin binding protein C (MYBPC3) represent the most frequent cause of familial hypertrophic cardiomyopathy (HCM), making up approximately 50% of identified HCM mutations. MYBPC3 is distinct among other sarcomere genes ...
Probiotics ameliorate renal ischemia-reperfusion injury by modulating the phenotype of macrophages through the IL-10/GSK-3β/PTEN signaling pathway [0.03%]
益生菌通过IL-10/GSK-3β/PTEN信号通路调节巨噬细胞表型以改善肾缺血再灌注损伤
Chenguang Ding,Feng Han,Heli Xiang et al.
Chenguang Ding et al.
After renal ischemic reperfusion injury, a series of pathological changes, such as impaired intestinal barrier function, intestinal flora, and endotoxin translocation, are caused by intestinal ischemia and hypoxia, which then trigger system...
Endurance exercise protects skeletal muscle against both doxorubicin-induced and inactivity-induced muscle wasting [0.03%]
耐力运动可防止阿霉素诱导和不活动引起的肌肉消耗性病症
Scott K Powers,Jose A Duarte,Branden Le Nguyen et al.
Scott K Powers et al.
Repeated bouts of endurance exercise promotes numerous biochemical adaptations in skeletal muscle fibers resulting in a muscle phenotype that is protected against a variety of homeostatic challenges; these exercise-induced changes in muscle...