Breaking the link between sarcoplasmic reticulum calcium leakage and mitochondria to counteract unloading-induced muscle atrophy [0.03%]
打破肌浆网钙离子泄漏与线粒体之间的联系以对抗失载诱导的肌肉萎缩
Carlo Reggiani,Lorenzo Marcucci
Carlo Reggiani
In muscle fibers, unloading and disuse cause an increase in resting calcium concentrations in the cytosol and mitochondrial matrix. S107, a stabilizer of the Ryanodine Receptor calcium channel (RyR), blocks the leakage from the sarcoplasmic...
Mitochondrial ATP synthase 8 single-nucleotide polymorphism affects oxidative stress and survival of mice [0.03%]
线粒体ATP合成酶8单核苷酸多态性影响小鼠的氧化应激和生存率
Gesine Reichart,Johannes Mayer,Tursonjan Tokay et al.
Gesine Reichart et al.
Single-nucleotide polymorphisms in mitochondrial DNA (mtDNA) encoded genes of respiratory chain complexes are known to be associated with severe diseases and life-threatening syndromes. In the assembly of the ATP synthase, the enzyme that i...
Professor Helmut Acker (1939-2025) : A Pioneer in Oxygen Sensing and Molecular Physiology [0.03%]
赫尔穆特·阿克教授（1939-2025）：氧气感应和分子生理学的先驱
Till Acker,Joachim Fandrey,Jörgen Carlsson
Till Acker
Impact of combined exercise training in peripheral and diaphragm muscles and in mortality in a preclinical model of pulmonary arterial hypertension [0.03%]
联合运动训练对周围和膈肌肌肉及肺动脉高压临床前模型死亡率的影响
Thais C Freire,Antônio V Nascimento-Filho,Marília S Ferreira et al.
Thais C Freire et al.
Pulmonary arterial hypertension (PAH) is a progressive disease characterised by systemic oxidative stress and inflammation that extends beyond the pulmonary vasculature to the musculoskeletal system. Combined exercise training (ET), incorpo...
Effects of intrarenal afferent stimulation by bradykinin on renal sympathetic nerve activity: tonic inhibition contributing to renal function [0.03%]
缓激肽对肾交感神经活性的内肾传入刺激的影响：持续性抑制作用有利于肾脏功能
Eva Hutter,Tilmann Ditting,Martin Hindermann et al.
Eva Hutter et al.
Bradykinin (BK) may increase renal sodium excretion by decreasing tubular ENaC activity. Afferent renal nerve activity (ARNA) putatively controls renal sympathetic nerve activity (RSNA) involved in renal sodium handling. We recently found t...
Non-invasive motor unit analysis reveals specific responses during maximal muscle contraction under normobaric hypoxia [0.03%]
非侵入式运动神经元分析法揭示了正常反压力条件下肌肉收缩的最大特异性反应
Danilo Bondi,Giacomo Valli,Carmen Santangelo et al.
Danilo Bondi et al.
Hypoxia has been extensively studied as a stressor which pushes human bodily systems to responses and adaptations. Nevertheless, a few evidence exist onto constituent trains of motor unit action potential, despite recent advancements which ...
Comment on "spatially dependent tissue distribution of thyroid hormones by plasma thyroid hormone binding proteins" [0.03%]
关于“血浆甲状腺激素结合蛋白的组织分布的空间依赖性”的评论
Amnuay Kleebayoon,Viroj Wiwanitkit
Amnuay Kleebayoon
Enhancing the quantification of post-occlusive reactive hyperemia: a multimodal optical approach [0.03%]
增强血流充盈反应的定量方法：一种多模态光学方法
Henrique Silva,Carlota Rezendes,Pedro Contreiras Pinto
Henrique Silva
Post-occlusive reactive hyperemia (PORH) is a physiological response marked by a transient increase in microvascular perfusion following ischemia. While cutaneous perfusion during PORH has been extensively characterized using optical approa...
Increased weight-bearing load reduces biological body weight while sodium and water balances are unaffected [0.03%]
增加承重负荷会减少生物体重而钠和水的平衡不受影响
Jovana Zlatkovic,Jakob Bellman,Daniel Hägg et al.
Jovana Zlatkovic et al.
Increased weight-bearing load has previously been shown to reduce body weight in obese rodents, primarily by lowering food intake. However, it remains unclear whether increased loading also affects body weight through acute changes in extra...
Evaluation of the use of the myocardial performance index as a parameter of cardiac function in two experimental models of heart disease: myocardial infarction and pulmonary hypertension [0.03%]
心肌性能指数在两种心脏病实验模型中作为心脏功能参数的价值评估：心梗和肺动脉高压
Alexandre Luz de Castro,Patrick Turck,Angela Maria Vicente Tavares et al.
Alexandre Luz de Castro et al.
Myocardial performance index (MPI) has been used in the estimation of ventricular function in a non-invasive way through echocardiography. This index has presented relevant results in clinical and experimental studies. However, there are no...