Connexin43 enhances Wnt and PGE2-dependent activation of β-catenin in osteoblasts [0.03%]
缝隙蛋白43促进成骨细胞中Wnt和PGE2依赖的β-连环蛋白激活作用
Aditi Gupta,Saimai Chatree,Atum M Buo et al.
Aditi Gupta et al.
Connexin43 is an important modulator of many signaling pathways in bone. β-Catenin, a key regulator of the osteoblast differentiation and function, is among the pathways downstream of connexin43-dependent intercellular communication. There...
Circadian rhythm of activin A and related parameters of mineral metabolism in normal and uremic rats [0.03%]
正常血和尿毒血大鼠活动素A及其相关矿质代谢参数的日节律性研究
Anders Nordholm,Søren Egstrand,Eva Gravesen et al.
Anders Nordholm et al.
Activin A is a new fascinating player in chronic kidney disease-mineral and bone disorder (CKD-MBD), which is implicated in progressive renal disease, vascular calcification, and osteodystrophy. Plasma activin A rises early in the progressi...
Age-related dysfunction of the autophago-lysosomal pathway in human endothelial cells [0.03%]
人类内皮细胞中与年龄有关的自噬溶酶体途径功能障碍
Sören Mai,Nadine Brehm,Georg Auburger et al.
Sören Mai et al.
Senescent cells, which are cells in a post-proliferative state, show an increased number of dysfunctional mitochondria and oxidatively damaged and aggregated proteins. The mitochondrial-lysosomal axis theory of aging proposes that the autop...
Jinsung Kim,Juyeon Ko,Jongyun Myeong et al.
Jinsung Kim et al.
Transient receptor potential canonical (TRPC) channels are calcium permeable, non-selective cation channels with wide tissue-specific distribution. Among 7 TRPC channels, TRPC 1/4/5 and TRPC3/6/7 are subdivided based on amino acid sequence ...
Cholera toxin perturbs the paracellular barrier in the small intestinal epithelium of rats by affecting claudin-2 and tricellulin [0.03%]
霍乱毒素通过影响闭合蛋白-2和三细胞连接蛋白扰乱大鼠小肠上皮的旁细胞屏障功能
Alexander G Markov,Olga N Vishnevskaya,Larisa S Okorokova et al.
Alexander G Markov et al.
Cholera toxin is commonly known to induce chloride secretion of the intestine. In recent years, effects on epithelial barrier function have been reported, indicating synergistic co-regulation of transporters and tight junction proteins. Our...
Determining differences between critical closing pressure and resistance-area product: responses of the healthy young and old to hypocapnia [0.03%]
健康年轻人和老年人对低碳酸血症的反应：临界闭合压与阻力面积乘积的区别
Jatinder S Minhas,Victoria J Haunton,Thompson G Robinson et al.
Jatinder S Minhas et al.
Healthy ageing has been associated with lower cerebral blood flow velocities (CBFVs); however, the behaviour of hemodynamic parameters associated with cerebrovascular tone (critical closing pressure, CrCP) and cerebrovascular resistance (re...
Friederike Stumpff,David Manneck,Holger Martens
Friederike Stumpff
Chronic treatment with C-type natriuretic peptide impacts differently in the aorta of normotensive and hypertensive rats [0.03%]
C型利钠肽慢性治疗对正常血压和高血压大鼠主动脉的影响不同
Carolina Caniffi,Flavia M Cerniello,Gonzalo Bouchet et al.
Carolina Caniffi et al.
The aim of this study was to determine whether exogenous administration of C-type natriuretic peptide (CNP) induces functional and morphological vascular changes in spontaneously hypertensive rats (SHR) compared with normotensive rats. Male...
Chronic AICAR treatment prevents metabolic changes in cardiomyocytes exposed to free fatty acids [0.03%]
氯代氨基异丁酸慢性治疗可预防游离脂肪酸暴露的心肌细胞的代谢变化
Christelle Viglino,Bernard Foglia,Christophe Montessuit
Christelle Viglino
The stimulation of glucose transport by metabolic stress is an important determinant of myocardial susceptibility to ischemia and reperfusion injury. Stimulation of glucose transport is markedly impaired in cardiomyocytes chronically expose...
miR-141-3p affects apoptosis and migration of endometrial stromal cells by targeting KLF-12 [0.03%]
microRNA-141-3p通过靶向KLF-12影响子宫内膜间质细胞凋亡和迁移
Yiwei Zhang,Juan Yan,Xiaowei Pan
Yiwei Zhang
Endometriosis is an estrogen-dependent disease that is characterized by pelvic pain and infertility. MicroRNAs have been shown to implicate in the progression of endometriosis. In our study, we used real-time PCR to evaluate the expression ...