Amplification of the COX/TXS/TP receptor pathway enhances uridine diphosphate-induced contraction by advanced glycation end products in rat carotid arteries [0.03%]
AGEs通过COX / TXS / TP受体途径放大机制增强尿苷二磷酸诱导的血管收缩作用：在大鼠颈动脉中的研究
Takayuki Matsumoto,Mihoka Kojima,Keisuke Takayanagi et al.
Takayuki Matsumoto et al.
Advanced glycation end products (AGEs) play a pivotal role in vascular functions under various pathophysiological conditions. Although uridine diphosphate (UDP) is an important extracellular nucleotide, the relationship between AGEs and UDP...
Lanying Yu,Tiantian Liu,Shuang Fu et al.
Lanying Yu et al.
Urea transporters (UTs) are membrane proteins in the urea transporter protein A (UT-A) and urea transporter protein B (UT-B) families. UT-B is mainly expressed in endothelial cell membrane of the renal medulla and in other tissues, includin...
miR-135a deficiency inhibits the AR42J cells damage in cerulein-induced acute pancreatitis through targeting FAM129A [0.03%]
miR-135a缺失通过靶向FAM129A抑制胰管腺AR42J细胞急性胰腺炎损伤
Kai-Kai Zhang,Shan-Shan Yu,Gui-Yun Li et al.
Kai-Kai Zhang et al.
Acute pancreatitis (AP) is a common clinical critical disease with high mortality and the exact pathogenesis is not fully elucidated. The present study aimed to uncover the function of miR-135a in the proliferation, apoptosis, and inflammat...
The role of WNK in modulation of KCl cotransport activity in red cells from normal individuals and patients with sickle cell anaemia [0.03%]
WNK在正常人和镰状细胞贫血症患者红细胞中KCl同向转运活性调节中的作用
David C-Y Lu,Anke Hannemann,Rasiqh Wadud et al.
David C-Y Lu et al.
Abnormal activity of red cell KCl cotransport (KCC) is involved in pathogenesis of sickle cell anaemia (SCA). KCC-mediated solute loss causes shrinkage, concentrates HbS, and promotes HbS polymerisation. Red cell KCC also responds to variou...
Butyric acid, a gut bacteria metabolite, lowers arterial blood pressure via colon-vagus nerve signaling and GPR41/43 receptors [0.03%]
丁酸盐通过结肠-迷走神经信号和GPR41 / 43受体降低动脉血压
Maksymilian Onyszkiewicz,Marta Gawrys-Kopczynska,Piotr Konopelski et al.
Maksymilian Onyszkiewicz et al.
Butyric acid (BA) is a short-chain fatty acid (SCFA) produced by gut bacteria in the colon. We hypothesized that colon-derived BA may affect hemodynamics. Arterial blood pressure (BP) and heart rate (HR) were recorded in anesthetized, male,...
β1 and β3 subunits amplify mechanosensitivity of the cardiac voltage-gated sodium channel Nav1.5 [0.03%]
Nav1.5心脏电压门控钠通道的β1和β3亚单位放大其机械敏感性
Michele Maroni,Jannis Körner,Jürgen Schüttler et al.
Michele Maroni et al.
In cardiomyocytes, electrical activity is coupled to cellular contraction, thus exposing all proteins expressed in the sarcolemma to mechanical stress. The voltage-gated sodium channel Nav1.5 is the main contributor to the rising phase of t...
ATP-sensitive K+ channels and mitochondrial permeability transition pore mediate effects of hydrogen sulfide on cytosolic Ca2+ homeostasis and insulin secretion in β-cells [0.03%]
硫化氢对β细胞胞浆钙稳态和胰岛素分泌作用的介导与ATP敏感型钾通道和线粒体渗透转换孔的关系
Aizhu Lu,Cencen Chu,Erin Mulvihill et al.
Aizhu Lu et al.
Hydrogen sulfide (H2S) is endogenously produced in pancreatic ß cells and its level is elevated in diabetes. Here, we report that H2S affects insulin secretion via two mechanisms that converge on cytosolic free Ca2+ ([Ca2+]i), a key mediat...
MiR-495 regulates macrophage M1/M2 polarization and insulin resistance in high-fat diet-fed mice via targeting FTO [0.03%]
MiR-495通过靶向FTO调节高脂饮食喂养小鼠的巨噬细胞M1/M2极化和胰岛素抵抗
Fang Hu,Jingkai Tong,Bangli Deng et al.
Fang Hu et al.
MicroRNA 495 (miR-495) has been discovered to be involved in the metabolism and immune response in human body. The purpose of this study was to investigate the effect of miR-495 on macrophage M1/M2 polarization and insulin resistance in typ...
Orexin A-induced inhibition of leptin expression and secretion in adipocytes reducing plasma leptin levels and hypothalamic leptin resistance [0.03%]
下丘脑黑素皮质素受体4介导血清瘦素水平昼夜节律的机制研究
Su-Kyung Shin,Seung-Eun Song,Jin Uk Oh et al.
Su-Kyung Shin et al.
Orexin A (OXA) is a neuropeptide associated with plasma insulin and leptin levels involved in body weight and appetite regulation. However, little is known about the effect of OXA on leptin secretion in adipocytes and its physiological role...