Modulation of hypercapnic respiratory response by cholinergic transmission in the commissural nucleus of the solitary tract [0.03%]
迷走神经孤束核胆碱能传递在高碳酸血症呼吸反应调制中的作用
Werner I Furuya,Mirian Bassi,José V Menani et al.
Werner I Furuya et al.
The nucleus of the solitary tract (NTS) is an important area of the brainstem that receives and integrates afferent cardiorespiratory sensorial information, including those from arterial chemoreceptors and baroreceptors. It was described th...
Complexin I knockout rats exhibit a complex neurobehavioral phenotype including profound ataxia and marked deficits in lifespan [0.03%]
复杂素I基因敲除大鼠表现出复杂的神经行为表型包括严重的共济失调和显著的寿命缺陷
Yang Xu,Xiao-Ming Zhao,Jia Liu et al.
Yang Xu et al.
Complexin I (CPLX1), a presynaptic small molecule protein, forms SNARE complex in the central nervous system involved in the anchoring, pre-excitation, and fusion of axonal end vesicles. Abnormal expression of CPLX1 occurs in several neurod...
Voltage-dependent gating in K channels: experimental results and quantitative models [0.03%]
电压门控钾通道：实验结果和定量模型
Luigi Catacuzzeno,Luigi Sforna,Fabio Franciolini
Luigi Catacuzzeno
Voltage-dependent K channels open and close in response to voltage changes across the cell membrane. This voltage dependence was postulated to depend on the presence of charged particles moving through the membrane in response to voltage ch...
RIM2α/RBP2/β-subunit co-expression stabilizes slow Cav1.3 channel inactivation to improve auditory perception [0.03%]
RIM2α/RBP2/β-亚基共表达稳定慢Cav1.3通道失活以改善听觉感知
Emilio Carbone
Emilio Carbone
RBP2 stabilizes slow Cav1.3 Ca2+ channel inactivation properties of cochlear inner hair cells [0.03%]
RBP2稳定耳蜗内毛细胞慢Cav1.3钙通道的失活性质
Nadine J Ortner,Alexandra Pinggera,Nadja T Hofer et al.
Nadine J Ortner et al.
Cav1.3 L-type Ca2+ channels (LTCCs) in cochlear inner hair cells (IHCs) are essential for hearing as they convert sound-induced graded receptor potentials into tonic postsynaptic glutamate release. To enable fast and indefatigable presynapt...
Neuronal nitric oxide synthase regulation of calcium cycling in ventricular cardiomyocytes is independent of Cav1.2 channel modulation under basal conditions [0.03%]
硝酸氧化酶对基线条件下室性心肌细胞钙循环的调节独立于Cav1.2通道调解
Janine Ebner,Michal Cagalinec,Helmut Kubista et al.
Janine Ebner et al.
Neuronal nitric oxide synthase (nNOS) is considered a regulator of Cav1.2 L-type Ca2+ channels and downstream Ca2+ cycling in the heart. The commonest view is that nitric oxide (NO), generated by nNOS activity in cardiomyocytes, reduces the...
Impact of skeletal muscle IL-6 on subcutaneous and visceral adipose tissue metabolism immediately after high- and moderate-intensity exercises [0.03%]
骨骼肌来源的IL-6对高强度和中等强度运动后即刻的皮下及内脏脂肪组织代谢的影响
Lærke Bertholdt,Anders Gudiksen,Stine Ringholm et al.
Lærke Bertholdt et al.
White adipose tissue is a major energy reserve for the body and is essential for providing fatty acids for other tissues when needed. Skeletal muscle interleukin-6 (IL-6) has been shown to be secreted from the working muscle and has been su...
Joachim Fandrey,Johannes Schödel,Kai-Uwe Eckardt et al.
Joachim Fandrey et al.
The recent bestowal of the Nobel Prize 2019 in Physiology or Medicine to Gregg L. Semenza, Sir Peter J. Ratcliffe, and William G. Kaelin Jr. celebrates a series of remarkable discoveries that span from the physiological research question on...
The functional association between the sodium/bicarbonate cotransporter (NBC) and the soluble adenylyl cyclase (sAC) modulates cardiac contractility [0.03%]
可溶性腺苷酸环化酶(sAC)与Na+/HCO3-同向转运蛋白(NBC)的功能联系调控心肌收缩力
María S Espejo,Alejandro Orlowski,Alejandro M Ibañez et al.
María S Espejo et al.
The soluble adenylyl cyclase (sAC) was identified in the heart as another source of cyclic AMP (cAMP). However, its cardiac physiological function is unknown. On the other hand, the cardiac Na+/HCO3- cotransporter (NBC) promotes the cellula...