The crucial decade that ion channels were proven to exist : The vision of Bertil Hille and Clay Armstrong and how it came through [0.03%]
决定性的一十年：离子通道的存在被证实的时代——Bertil Hille和Clay Armstrong的远见及其实现之路
Luigi Catacuzzeno,Antonio Michelucci,Fabio Franciolini
Luigi Catacuzzeno
This retrospective begins with the first recording of the Na+ and K+ currents underlying the action potential in the giant squid axon reported by Hodgkin and Huxley in 1952, which made the question of where ions pass through the membrane mo...
Impact of aldosterone deficiency on the development of diuretic resistance in mice [0.03%]
醛固酮缺乏对小鼠利尿剂耐药性发展的影响
Daniel Essigke,M Zaher Kalo,Andrea Janessa et al.
Daniel Essigke et al.
The effect of diuretics can be limited by stimulation of counter-regulatory mechanisms, eventually leading to diuretic resistance. It is thought that the mineralocorticoid aldosterone might contribute to the development of diuretic resistan...
Inhibition of Rho-kinase by fasudil contributes to the modulation of the synaptic plasticity response in the rat hippocampus [0.03%]
法舒地尔通过抑制Rho激酶参与调节大鼠海马区的突触可塑性反应
Ercan Babur,Hatice Saray,Cem Süer et al.
Ercan Babur et al.
Metaplasticity refers to an activity-dependent change in the physiological or biochemical state of neurons that changes their ability to generate subsequently induced synaptic plasticity, such as long-term potentiation (LTP) or long-term de...
The enigma of ENaC activation by proteolytic cleavage: a never ending quest? [0.03%]
由蛋白水解切割激活ENaC之谜：一次永无止境的探索？
Eric Feraille,Ali Sassi,Monika Gjorgjieva
Eric Feraille
The NFAT5 chronicles: a transcription factor's tale of hypoxia, pulmonary drama, and endothelial resilience to hypoxia [0.03%]
NFAT5编年史：一个转录因子在低氧、肺部剧变和内皮细胞对低氧的韧性中的故事
Dörthe M Katschinski
Dörthe M Katschinski
Intracellular pH regulates the strength of the intrinsic inward rectification of Kir4.1/Kir5.1 channels [0.03%]
细胞内pH调节Kir4.1/Kir5.1通道内在整流强度
Iván A Aréchiga-Figueroa,Leticia G Marmolejo-Murillo,Mayra Delgado-Ramírez et al.
Iván A Aréchiga-Figueroa et al.
Kir4.1/Kir5.1 channels play a crucial role in important physiological functions, notably in the kidneys and brain. A hallmark of these channels is the coexistence of two mechanisms of inward rectification: the classical "extrinsic" inward r...
Intrinsic responses to hypoxia and hypercapnia of neurons in the cardiorespiratory center of the ventral medulla of newborn rats [0.03%]
新生大鼠延髓呼吸心血管中枢区神经元对低氧和高碳酸血症的内在反应
Hiroshi Onimaru,Yui Koyanagi,Kamon Iigaya et al.
Hiroshi Onimaru et al.
The rostral ventrolateral medulla (RVLM) includes a variety of neurons essential for cardiorespiratory control. Although some of these neurons are thought to be intrinsically sensitive to hypercapnia and/or hypoxia, relationships between ty...
Reproducibility of smooth muscle mechanical properties in consecutive stretch and activation protocols [0.03%]
连续拉伸和激活协议中平滑肌机械性能的可重复性
Simon Kiem,Stefan Papenkort,Mischa Borsdorf et al.
Simon Kiem et al.
Mechanical organ models are crucial for understanding organ function and clinical applications. These models rely on input data regarding smooth muscle properties, typically gathered from experiments involving stimulations at different musc...
Microbiota, mitochondria, and epigenetics in health and disease: converging pathways to solve the puzzle [0.03%]
健康与疾病的微生物群，线粒体和表观遗传学：解决谜题的汇聚途径
Natalia Lucia Rukavina Mikusic,Paula Denise Prince,Marcelo Roberto Choi et al.
Natalia Lucia Rukavina Mikusic et al.
Dysbiosis, which refers to an imbalance in the composition of the gut microbiome, has been associated with a range of metabolic disorders, including type 2 diabetes, obesity, and metabolic syndrome. Although the exact mechanisms connecting ...
Comprehensive overview of artificial intelligence in surgery: a systematic review and perspectives [0.03%]
手术中人工智能的综合概述：系统性回顾与展望
Olivia Chevalier,Gérard Dubey,Amine Benkabbou et al.
Olivia Chevalier et al.
The rapid integration of artificial intelligence (AI) into surgical practice necessitates a comprehensive evaluation of its applications, challenges, and physiological impact. This systematic review synthesizes current AI applications in su...